Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To examine the individual and combined associations of ApoE and MTHFR 677C/T polymorphisms with cognitive performance in adolescents.
Study Design: The study comprised 412 Spanish adolescents (13 to 18.5 years of age). Cognitive performance (verbal, numeric and reasoning abilities, and an overall score) was measured by the Spanish-version of the SRA-Test of Educational-Ability.
Results: We observed no differences in the cognitive performance study variables in adolescents carrying or not carrying the ApoE epsilon4 variant. Adolescents without the MTHFR 677TT genotype had significantly better cognitive performance than their TT peers. The analysis of the combined effect of these polymorphisms revealed that those individuals carrying both the ApoE epsilon4 variant and the MTHFR 677TT genotype had significantly worse cognitive performance than their peers with other genotype combinations. These findings were independent of sex, age pubertal status, socioeconomic status, physical activity, and skipping breakfast.
Conclusions: The results of the present study suggest that the ApoE epsilon4 alone is not associated with cognitive performance in adolescents. Individuals with the MTHFR 677TT genotype had slightly impaired cognitive performance, whereas we observed a combined effect of both the ApoE epsilon4 variant and the MTHFR 677TT genotype on cognitive performance. More research is needed in larger population samples to corroborate our findings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpeds.2009.12.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association between medium-chain triglyceride intake and Functional Independence Measure-cognition score in adults following stroke: A retrospective cohort study.
JPEN J Parenter Enteral Nutr
September 2025
Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan.
Background: Limited evidence exists regarding the cognitive and physical improvement effects of medium-chain triglyceride (MCT) intake in patients with stroke. This study aimed to investigate the association between MCT-enhanced rice consumption and enhancements in outcomes, including cognitive level, in patients following stroke.
Methods: We performed a retrospective cohort study on adults admitted to a rehabilitation center with cognitive decline following acute stroke.
A comprehensive guide to digital neurology. An update on current development on digital neurology derived from the Digital Neuro Hub project.
Neurol Sci
September 2025
Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
The rapid evolution of digital tools in recent years after COVID-19 pandemic has transformed diagnostic and therapeutic practice in neurology. This shift has highlighted the urgent need to integrate digital competencies into the training of future specialists. Key innovations such as telemedicine, artificial intelligence, and wearable health technologies have become central to improving healthcare delivery and accessibility.
View Article and Find Full Text PDFFrom semantic knowledge to semantic features: French semantic feature production norms for 360 concepts.
Behav Res Methods
September 2025
Laboratoire de Psychologie, Université de Bordeaux, LabPsy UR 4139, 3 Place de la Victoire, 33076, Bordeaux Cedex, France.
This article presents a new set of semantic feature production norms, collected from 580 young adults, for 360 French concepts across various semantic categories. Although empirically derived feature norms have been developed for several languages and have been shown to be useful for investigating semantic memory and providing assessment tools, none are currently available for native French-speaking populations. In this study, the participants performed a property generation task in which they were asked to list features to describe the characteristics of each given concept (e.
View Article and Find Full Text PDFThe influence of pure tacts and intraverbals on the transfer of verbal learning to new stimuli: Aan experimental study in children.
Learn Behav
September 2025
Departamento de Psicología, Facultad de Ciencias de la Educación y Psicología, Universidad de Córdoba, Calle San Alberto Magno, s/n, 14071, Córdoba, España.
This study investigates learning transfer processes in the teaching of pure tacts and intraverbals within the context of verbal behavior. The objectives were: to assess whether training pure tacts and intraverbals, through the inclusion of different stimuli, facilitates learning transfer to new impure tacts, and to determine whether one of these verbal operants (pure tact or intraverbal) better promotes learning transfer. The sample included 54 children aged 11-12 years, using a within-subjects experimental design with pre-post measures.
View Article and Find Full Text PDFAutophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.
Mol Psychiatry
September 2025
Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 44115, USA.
Dysregulated spine morphology is a common feature in the pathology of many neurodevelopmental and neuropsychiatric disorders. Overabundant immature dendritic spines in the hippocampus are causally related to cognitive deficits of Fragile X syndrome (FXS), the most common form of heritable intellectual disability. Recent findings from us and others indicate autophagy plays important roles in synaptic stability and morphology, and autophagy is downregulated in FXS neurons.
View Article and Find Full Text PDF