Triplex-stabilizing properties of parallel clamps carrying LNA derivatives at the Hoogsteen strand.

Chem Biodivers

Institute for Research in Biomedicine, IQAC-CSIC, CIBER-BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Edifici Helix, Baldiri Reixac 15, ES-08028 Barcelona, Spain.

Published: February 2010


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Article Abstract

DNA Parallel clamps with a polypurine strand linked to a polypyrimidine Hoogsteen strand containing locked nucleic acids bind their corresponding polypyrimidine targets with high affinity.

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http://dx.doi.org/10.1002/cbdv.200900230DOI Listing

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