Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Association of sulphatide with influenza A virus (IAV) haemagglutinin (HA) delivered to the cell surface promotes progeny virus production. However, it is not known whether there is direct binding of HA to sulphatide. In this study, we found that recombinant HA, which was produced by a baculovirus protein expression system from the HA gene of A/duck/HK/313/4/78 (H5N3), bound to sulphatide in a dose-dependent manner and that the binding was inhibited by a specific antibody. Our results indicate that the recombinant HA is useful for elucidation of the binding domain of HA with sulphatide and for the development of new anti-IAV agents.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jb/mvq013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Brassinosteroid signaling promotes sulfate uptake under sulfur deficiency in Arabidopsis.
New Phytol
October 2025
State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Sulfur (S) is a crucial macronutrient for plant growth, development, and stress tolerance. It serves as an essential component of amino acids (cysteine and methionine), vitamins, sulfatides, and coenzymes. S deficiency impairs plant productivity; yet, the molecular mechanisms regulating sulfate uptake remain poorly understood.
View Article and Find Full Text PDFMoOrp-mediated PtdIns4P transportation is essential for autophagy and pathogenicity in .
Autophagy
July 2025
Department of Plant Pathology, MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, China.
Macroautophagy/autophagy is essential to the pathogenicity of . Phosphatidylinositol-4-phosphate (PtdIns4P) is a key lipid involved in the autophagy process. Recent studies have shown that the PtdIns4P pool on autophagic membranes is crucial to autophagosome biogenesis and fusion with the vacuole; however, the mechanism regulating the PtdIns4P levels on autophagic membranes is still unclear.
View Article and Find Full Text PDFSoybean Lectin Cross-Links Membranes by Binding Sulfatide in a Curvature-Dependent Manner.
J Agric Food Chem
June 2025
Protein Signaling Domains Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute, and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, Virginia 24061, United States.
Soybean () is a key source of plant-based protein, yet its nutritional value is impacted by antinutritional factors, including lectins. Whereas soybean lectin is known to bind -acetyl-d-galactosamine (GalNAc), its lipid interactions remain unexplored. Using a novel purification method, we isolated lectin from soybean meals and characterized its interactions with GalNAc and the glycosphingolipid sulfatide.
View Article and Find Full Text PDFSulfatide Binds to Influenza B Virus and Enhances Viral Replication.
Viruses
April 2025
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Shizuoka, Japan.
Seasonal influenza epidemics caused by influenza A viruses (IAV) and influenza B viruses (IBV) pose a substantial public health burden. Despite the significant impact of IBV, its restricted host range and the absence of documented pandemics have resulted in limited research attention relative to IAV. Understanding the viral infection mechanisms of both IAV and IBV is crucial for controlling seasonal epidemics.
View Article and Find Full Text PDFLarge-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome.
Brain
March 2025
School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ, Glasgow, UK.
Guillain-Barré syndrome is an acute polyradiculoneuropathy in which preceding infections often elicit the production of antibodies that target peripheral nerve antigens, principally gangliosides. Anti-ganglioside antibodies are thought to play a key role in the clinical diversity of the disease and can be helpful in clinical practice. Extensive research into clinical associations of individual anti-ganglioside antibody specificities has been performed.
View Article and Find Full Text PDF