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A quiet methodological revolution, a modeling revolution, has occurred over the past several decades, almost without discussion. In contrast, the 20th century ended with contentious argument over the utility of null hypothesis significance testing (NHST). The NHST controversy may have been at least partially irrelevant, because in certain ways the modeling revolution obviated the NHST argument. I begin with a history of NHST and modeling and their relation to one another. Next, I define and illustrate principles involved in developing and evaluating mathematical models. Following, I discuss the difference between using statistical procedures within a rule-based framework and building mathematical models from a scientific epistemology. Only the former is treated carefully in most psychology graduate training. The pedagogical implications of this imbalance and the revised pedagogy required to account for the modeling revolution are described. To conclude, I discuss how attention to modeling implies shifting statistical practice in certain progressive ways. The epistemological basis of statistics has moved away from being a set of procedures, applied mechanistically, and moved toward building and evaluating statistical and scientific models.
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http://dx.doi.org/10.1037/a0018326 | DOI Listing |
ChemMedChem
September 2025
Faculty of Pharmacy, PHENIKAA University, Hanoi, 12116, Vietnam.
Antimicrobial peptides (AMPs) have emerged as promising candidates for combating drug-resistant pathogens and certain cancer types. However, their therapeutic applications are often limited by undesired hemolytic activity, while many AMPs exhibit only moderate potency. Herein, the "helical wheel rotation" strategy as a simple, cost-effective, and modular approach to optimize the pharmacological properties of amphipathic α-helical AMPs without altering their amino acid composition is explored.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
September 2025
Department of Chemical System Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
The effect of shape and size of embolic agents on embolization phenomena has been discussed clinically for transcatheter arterial chemoembolization (TACE). We numerically discussed the unique embolization behavior of new deformable toroidal microparticles in blood vessels by computational fluid dynamics simulations. We employed an Eulerian-Eulerian (full Eulerian) fluid-structure interaction (FSI) method to analyze the flow and deformation behaviors of a deformable torus in a cylindrical pipe.
View Article and Find Full Text PDFFront Sociol
August 2025
Laboratory of Anthropology of Contemporary Worlds (LAMC), Faculty of Philosophy and Social Sciences, Institute of Sociology, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Contemporary debates about artificial intelligence (AI) still treat automation as a straightforward substitution of human labor by machines. Drawing on Goffman's dramaturgical sociology, this paper reframes AI in the workplace as rather than automation. We argue that the central-but routinely overlooked-terrain of struggle is symbolic-interactional: workers continuously stage, conceal, and re-negotiate what counts as "real" work and professional competence.
View Article and Find Full Text PDFJ Med Educ Curric Dev
September 2025
Department of Oncology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Objectives: To explore the efficacy of a novel teaching model based on the Monaco planning system in radiation oncology education.
Methods: Forty clinical undergraduate medical interns were randomized and equally divided into a control group and an experimental group. The experimental group underwent the Monaco planning system-based teaching model, while the control group received conventional clinical teaching activities.
Eur J Midwifery
September 2025
Midwifery School, Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy.
Introduction: Optimal fetal positioning is essential for ensuring that labor progresses efficiently and reducing the need for interventions. The aim of this study was to evaluate the potential role of the Spinning Babies approach to facilitate fetal head rotation.
Methods: This retrospective study was based on data collected by midwifery students, supervised by experienced midwifery tutors, using digital partograms.