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Background: Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances.
Methods: A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. Quantitative skin prick tests (SPT) and bronchial challenge tests with a dosimeter protocol were performed with quadrupling doses of the sodium chloride salts of rhodium (Na(3)RhCl(6)) and platinum (Na(2)PtCl(6)).
Results: The patient showed positive SPT reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt; the molar concentrations differed by a factor of 256 in SPT and a factor of 16 in bronchial challenges.
Conclusions: Rhodium salts should be considered as occupational immediate-type allergens.
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http://dx.doi.org/10.1002/ajim.20786 | DOI Listing |
Pharmaceutics
July 2025
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de México C.P. 04510, Mexico.
The increasing prevalence of multidrug-resistant (MDR) bacteria, particularly , calls for the development of new antimicrobial agents. This study investigates a series of fluorinated azolium salts and their rhodium(I) complexes for antibacterial activity against clinical and reference strains of . : Eleven fluorinated azolium salts and their corresponding Rh(I) complexes (22 compounds total) were synthesized and tested against several strains, including three MDR clinical isolates (U-13685, H-9871, U-13815) and ATCC reference strains.
View Article and Find Full Text PDFChemistry
August 2025
Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu, 600036, India.
To study the role of hemilabile ligands in B─H bond activation, κ-N,E-chelated iridium and rhodium complexes, [Cp*M(κ-E-CHNE)(κ-N,E-CHNE)] (2a: M = Ir, E = S; 2b: M = Ir, E = Se; 2c: M = Rh, E = S; 2b: M = Rh, E = Se) have been synthesized by salt metathesis reactions of [Cp*MCl] (1a: M = Ir, 1a: M = Rh) and potassium salts of thio-/seleno-pyridine ligands. The strained four-membered rings in 2a-d indicate their potential for activating small molecules. Indeed, treatment of 2a-b with [BH⋅THF] afforded monometallic diborane(5) complexes, [(Cp*IrH){κ-B,B,Se-(BH-CHNE)}] (3a: E = S, 3b: E = Se) and transition metal (TM)-dihydroborate complexes, [(η-CMeH)Ir{κ-H,H,E-(HB-CHNE))] (4a: E = S, 4b: E = Se).
View Article and Find Full Text PDFChem Sci
June 2025
Department of Chemistry, Texas A&M University College Station TX 77843 USA
As part of our study of ambiphilic carbenium-based ligands, we now report on the coordination chemistry of the known acridinium phosphine ligand [(-PhP(CH)Acr)] ([L], Acr = 9--methylacridinium) towards rhodium(i) reagents. While the simple coordination complex [LRh(COD)Cl] ([1]) is obtained from [L] and [Rh(COD)Cl] (COD = 1,5-cyclooctadiene) in CHCl, the use of [Rh(COE)Cl] (COE = cyclooctene) in MeCN affords [(-PhP(CH)Acr)Rh(MeCN)Cl] ([2] ), a chloride-bridged dimeric complex in which each rhodium atom is involved in a Rh→C dative bond (C = acridinium C9 atom), indicating Z-type behavior of the acridinium unit. The same reaction in CHCl affords [(-PhP(CH)Acr)RhCl] ([3] ), a chloride-bridged dimeric square planar complex in which the acridinium assumes the role of an η-heteroarene, L-type ligand.
View Article and Find Full Text PDFAcc Chem Res
March 2025
Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
ConspectusIn contrast to precious transition metals, such as palladium and rhodium, the development of novel chiral ligands for enantioselective C-H functionalizations catalyzed by earth-abundant, cost-effective, and environmentally friendly 3d metals poses substantial challenges, primarily due to the variable oxidation states, intricate coordination patterns, and limited mechanistic insights. In this Account, we summarize our research endeavors in the development of three novel types of Co(III) catalysis: pseudotetrahedral achiral Cp*Co(III)/chiral carbonyl acid (CCA) catalysis, -generated chiral octahedral cobalt(III) via cobalt/salicyloxazoline (Salox) catalysis, and Co(II)/chiral phosphoric acid (CPA) cooperative catalysis, achieved through strategic chiral ligand design. Our initial objective was to achieve enantioselective C-H functionalization catalyzed by achiral Cp*Co(III) catalysts with external chiral ligands, aiming to circumvent the laborious preparation of chiral CpCo(III) complexes.
View Article and Find Full Text PDFChem Commun (Camb)
February 2025
Department of Chemistry, Western University, 1151 Richmond St, London, ON, N8K 3G6, Canada.
Studies that independently investigate [M]-C transmetalation reactions using two different metals are uncommon and yet understanding this reactivity is important to unlocking new synthetic approaches and product classes. Here, we show that the strained [Fe]-C complex, [(η-CMe-CH)Fe(diphosphine)] undergoes transmetalation with rhodium(I) and iridium(I) diolefin salts, leading to rapid Fe-C(sp) bond cleavage and M-C(sp) (M = Rh or Ir) bond generation.
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