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Article Abstract
Background: Bovine Leukemia virus (BLV) is a deltaretrovirus that induces lymphoproliferation and leukemia in ruminants. In ex vivo cultures of B lymphocytes isolated from BLV-infected sheep show that spontaneous apoptosis is reduced. Here, we investigated the involvement of reactive oxygen species (ROS) in this process.
Results: We demonstrate that (i) the levels of ROS and a major product of oxidative stress (8-OHdG) are reduced, while the thioredoxin antioxidant protein is highly expressed in BLV-infected B lymphocytes, (ii) induction of ROS by valproate (VPA) is pro-apoptotic, (iii) inversely, the scavenging of ROS with N-acetylcysteine inhibits apoptosis, and finally (iv) the levels of ROS inversely correlate with the proviral loads.
Conclusion: Together, these observations underline the importance of ROS in the mechanisms of inhibition of apoptosis linked to BLV infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779800 | PMC |
| http://dx.doi.org/10.1186/1742-4690-6-102 | DOI Listing |
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