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Ankylosing Spondylitis (AS) is a chronic condition which requires clinical assessment to inform the management of AS, the intent being to alleviate the symptoms and to improve the health of the suffering person. An integral part of the current assessment is the measurements taken of a number of subjective and objective factors that affect the person's health status. There is growing awareness that the protocols and means of taking the measurements are both inaccurate and inconsistent. This paper addresses how such assessments may be augmented by utilizing 3-dimensional visualisation technology to collect and present data of this multifaceted condition. The final goal of the research is to provide a relevant tool for AS that can be used in both clinical and home settings. It is designed to directly support the therapeutic regime, to enhance assessment, to provide meaningful feedback to both AS sufferers and clinicians alike and to facilitate the collection of objective evidence relating to the condition.
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J Pain Res
September 2025
Radiology Department, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
Purpose: Previous studies have revealed alterations of the functional connectivity of the brain networks in ankylosing spondylitis (AS). Fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) are both voxel-based functional metrics capable of estimating local spontaneous neural activities. This study aimed to investigate the local spontaneous neural activities in AS patients by utilizing the analytical approaches of fALFF and ReHo.
View Article and Find Full Text PDFCureus
August 2025
General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Ankylosing spondylitis (AS) is a chronic inflammatory spondyloarthropathy that predominantly affects the axial skeleton. While hallmark features such as sacroiliitis and syndesmophytes are well recognized, the presence of mediastinal masses may pose a diagnostic dilemma and raise concerns for malignancy or atypical infection. We report a middle-aged man in the fifth decade of life with longstanding untreated AS presenting with progressive quadriparesis.
View Article and Find Full Text PDFCureus
August 2025
Department of Internal Medicine, Local Health Unit of Santa Maria, Lisbon, PRT.
Polyarteritis nodosa (PAN) rarely affects both intracranial and mesenteric arteries. Evidence on optimal timing of revascularisation and the role of interleukin-6 blockade remains limited. A 73-year-old man with longstanding ankylosing spondylitis presented with weight loss and elevated inflammatory markers.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Oncology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Numerous observational studies have suggested links between sex hormones and various autoimmune diseases (ADs). However, the causality of these associations remains uncertain. This study employs Mendelian randomization (MR) analysis to investigate the causal relationship between sex hormones and ADs risk.
View Article and Find Full Text PDFReumatol Clin (Engl Ed)
September 2025
Hospital Universitario Fundación Alcorcón, Unit of Rheumatology, Madrid, Spain.
Objectives: To assess the effectiveness of a checklist for disease activity and comorbidity control in patients with axial spondyloarthritis (axSpA).
Method: A quasi-experimental retrospective multicentre pre-post intervention study was carried out in Spain between 2016 and 2022. Improvement in disease activity and comorbidity status was determined before and after the implementation of a checklist control in patients diagnosed with axSpA.