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http://dx.doi.org/10.4158/EP.15.3.273 | DOI Listing |
Front Plant Sci
August 2025
School of Biological Sciences, The University of Western Australia, Perth, Australia.
Agriculture is extremely vulnerable to climate change and crop production is severely hampered by climate extremes. Not only does it cost growers over US$170Bln in lost production, but it also has major implications for global food security. In this study, we argue that, under current climate scenarios, agriculture in the 21 century will become saline, severely limiting (or even making impossible) the use of traditional cereal crops for human caloric intake.
View Article and Find Full Text PDFFront Psychiatry
August 2025
Statistics Section of the Department of Genetics, Microbiology and Statistics, Universitat de Barcelona (UB), Barcelona, Spain.
Most methodological Polygenic Risk Score (PRS)-related papers explain the laborious process of computing the PRS in great depth. Afterwards, as a last step, it is generally described that to test a possible association between a PRS and a trait of interest, an analysis through regression models (linear or logistic, depending on data type) should be carried out adjusting for covariates (e.g.
View Article and Find Full Text PDFJ Gen Intern Med
September 2025
Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
The word clinical derives from the Greek klinikos, meaning "at the bedside, reflecting medicine's roots in human observation and presence. While a detailed history is foundational, a thoughtful physical examination remains critical for guiding diagnosis and comprehensive care. Yet modern clinical practice, driven by time constraints and reliance on technological advancements, has reduced the physical exam to a perfunctory ritual.
View Article and Find Full Text PDFNervenarzt
September 2025
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany.
The classification of psychotic disorders has undergone a variety of changes. Since Karl Ludwig Kahlbaum's (Kahlbaum 1874) first descriptions of catatonic states and Emil Kraepelin's (Kraepelin 1883) nosological classification of psychotic syndromes in the second half of the nineteenth century, the diagnostic criteria for these disorders have been repeatedly modified, significantly impacting clinical practice. Eugen Bleuler (Bleuler 1911) coined the term "schizophrenia", emphasizing the disturbances in thinking, feeling and acting that he had observed.
View Article and Find Full Text PDFCurr Res Pharmacol Drug Discov
August 2025
Department of Drug and Health Sciences, University of Catania, Catania, Italy.
In neuropathic pain (NP), a dysregulation of glial functions in the central and peripheral nervous systems has been described, and the balance between pro-inflammatory and anti-inflammatory mediators is lost in the transition from acute to chronic pain. This raises the possibility to resolve pain via the induction of anti-inflammatory cytokines that have a protective role against neuroinflammatory events. Transforming growth factor-β1 (TGF-β1), an anti-inflammatory cytokine is able to counteract the development of chronic NP.
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