Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We have previously demonstrated that differences in neuropathic pain-like behaviors after sciatic nerve injury genetically maps to the major histocompatibility complex (MHC) in rats carrying RT1(c) or RT1(av1) haplotypes on the Piebald Virol Glaxo (PVG) background. In order to further explore the genetic contribution to neuropathic pain, we have here examined the MHC-congenic rat strains PVG-RT1(n) and PVG-RT1(av1) and the inbred strains PVG (RT1(c)) and Brown-Norway (BN; RT1(n)). All studied strains developed mechanical hypersensitivity (allodynia-like behavior) of the hind paw after photochemically induced sciatic nerve injury. However, the PVG-RT1(n) and PVG strains displayed significantly more allodynia than PVG-RT1(av1) and BN rats. In addition, the BN strain demonstrated an elevated threshold for the baseline response. The results demonstrate that both MHC and non-MHC genes influence experimental neuropathic pain in rats and also suggest that allelic variation contained in the RT1(av1) haplotype on the PVG background protects against neuropathic pain.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neulet.2008.07.027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia.
Front Neurol
August 2025
Department of Neurosurgery, West China Hospital, Chengdu, China.
We report the results of a long-term follow-up series in our center to verify the impact of biologically effective dose (BED) on the efficacy and safety of Gamma Knife radiosurgery (GKS) in the treatment of primary trigeminal neuralgia (TN). A total of 138 consecutive cases of primary TN receiving GKS were included. A 4-mm collimator was used for all cases, and a median central dose of 85 Gy (range 70-90 Gy) was prescribed.
View Article and Find Full Text PDFNeural basis of transcutaneous electrical nerve stimulation for neuropathic pain relief.
Neuron
September 2025
Shanghai Stomatological Hospital & School of Stomatology, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China. Electronic address:
Existing treatments for chronic pain often prove ineffective and carry adverse side effects, highlighting the need for better analgesics, including non-pharmacological treatments. We demonstrate that transcutaneous electrical nerve stimulation (TENS), when repeatedly applied during the early phase of nerve injury in mice, produces sustained analgesic effects by activating the dorsal column nucleus (DCN)-thalamic-cortical pathway, which transmits vibration, discriminative touch, and proprioception. Mechanistically, TENS selectively activates glutamatergic neurons in the DCN (DCN) via exciting Aβ low-threshold mechanoreceptors (Aβ-LTMRs) in dorsal root ganglia (DRGs).
View Article and Find Full Text PDFEndoscopic transorbital approach for orbital cavernous hemangioma: A case series.
Neurochirurgie
September 2025
School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy; Neurosurgery, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Background: Orbital cavernous hemangiomas (OCH) are the most common benign orbital tumors, often presenting with proptosis. The endoscopic transorbital approach (ETOA) is increasingly being utilized for the treatment of OCH, offering minimal invasiveness and superior cosmetic outcomes. This study aims to evaluate the safety, efficacy, and clinical outcomes of ETOA for OCH.
View Article and Find Full Text PDFIon-channel mRNA expression alterations in a cervical dorsal horn compression induced novel rabbit model of trigeminal neuropathic pain.
Sci Prog
September 2025
Department of Neurology, University of Afyonkarahisar Health Sciences, Afyonkarahisar, Türkiye.
A considerable number of individuals are diagnosed with idiopathic trigeminal neuralgia. In order to achieve a more complete understanding of the pathophysiology, it is essential to adopt a range of novel approaches and utilize new animal models. This study investigated changes in the messenger RNA (mRNA) expression of ion-channels in a newly developed animal model of trigeminal neuropathic pain induced by cervical spinal dorsal horn compression.
View Article and Find Full Text PDFCurcumin Liposomal Nanoparticles Provide Superior Neuroprotection by Attenuating Neuropathic Pain, Neuroinflammation, and Anxiety in Chronic Sciatic Nerve Injury in rats.
J Drug Target
September 2025
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Background: Chronic constriction injury (CCI) of the sciatic nerve induces neuropathic pain, inflammation, oxidative stress, and neurodegenerative changes, impairing sensory and emotional function. While curcumin is well recognized for its anti-inflammatory and neuroprotective properties, its therapeutic use is limited by poor bioavailability. Curcumin liposomal nanoparticles (CLNs) offer improved delivery and stability.
View Article and Find Full Text PDF