Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: A recent study identified the single nucleotide polymorphism (SNP) rs2664538 within the MMP-9 gene with risk for acute primary angle closure glaucoma (PACG). The aim of this study was to confirm this association in Singaporean Chinese subjects with both acute and chronic PACG.
Methods: This was an observational cross-sectional study. Genomic DNA was extracted from leukocytes of peripheral blood and genotypes were determined by polymerase chain reaction and direct sequencing. The association of the SNP with PACG was evaluated using chi tests.
Results: A total of 217 subjects with PACG (consisting of 85 acute and 132 chronic PACG), and 83 normal control Chinese subjects were studied. There was no significant difference in the rs2664538 SNP allele frequencies for acute or chronic PACG subjects compared with controls.
Conclusions: This study did not find an association between the rs2664538 polymorphism within the MMP-9 gene and PACG in this sample of Chinese subjects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/IJG.0b013e31815c3aa5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intranasal zinc and vitamin A treatments alter response to bovine respiratory syncytial virus and co-infection.
Transl Anim Sci
August 2025
Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA.
During disease, there may be increased local demands for zinc (Zn) and vitamin A to support pathogen response. This study evaluates the effects of intranasal Zn and vitamin A treatments on steers experimentally infected with bovine respiratory disease (BRD) pathogens, bovine respiratory syncytial virus (BRSV) and , hypothesizing that steers treated with Zn and vitamin A (VA) will have improved recovery to BRD challenge. Forty-eight Angus crossbred steers (333 ± 4.
View Article and Find Full Text PDFBeyond function: supervised exercise therapy may target inflammatory gene expression in patients with symptomatic peripheral artery disease.
Vasa
September 2025
Angiology Department, Lausanne University Hospital, University of Lausanne, Switzerland.
Supervised exercise therapy (SET) is a first-line treatment for patients with symptomatic peripheral artery disease (PAD). However, its impact on inflammation, as well as the relationship between inflammation and functional improvements, remain poorly understood. In this prospective, single-arm study, 51 patients with symptomatic PAD underwent a 12-week multimodal SET program.
View Article and Find Full Text PDFSilencing CD151 Gene in Donor Triple-Negative Breast Cancer Cells Attenuates Exosome-Driven Functions of Recipient Cells.
Exp Cell Res
September 2025
Cancer Biology Laboratory, Dept of Life Sciences, GITAM School of Sciences, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India. Electronic address:
CD151 is a tetraspanin, abnormally expressed in triple negative breast cancer (TNBC). It is a prominent component of exosomes, facilitating the secretion of proteins that promote metastasis and drug resistance. We have previously demonstrated that silencing the CD151 gene reduces metastasis in TNBC.
View Article and Find Full Text PDFMolecular mechanisms of the Suting Pill in the treatment of asthma: A study based on network pharmacology and molecular docking.
Medicine (Baltimore)
September 2025
Department of Pharmacy, The Third Department, Air Force Special Service Sanatorium, Hangzhou, Zhejiang, China.
Background: Asthma is a chronic respiratory disease characterized by complex etiology and marked heterogeneity. It is one of the most prevalent chronic airway conditions in children, with increasing prevalence in recent years. The Suting Pill (STP), a traditional Chinese medicine for childhood asthma, has an unclear mechanism.
View Article and Find Full Text PDFKnockdown of UBD Ameliorates Experimental Rheumatoid Arthritis by Suppressing TLR4/Myd88/NF-κB and P38/MAPK Pathway.
Cell Physiol Biochem
September 2025
Department of General Practice, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China, E-Mail:
Background/aims: Ubiquitin D (UBD), a member of the ubiquitin-like modifier (UBL) family, is significantly overexpressed in various cancers and is positively correlated with tumor progression. However, the role and underlying mechanisms of UBD in rheumatoid arthritis (RA) remain poorly understood. This study aimed to investigate the effects of UBD knockdown on the progression of RA.
View Article and Find Full Text PDF