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UK Biobank required a cryogenic facility to store, in vapour phase, a minimum of 5 000 000 1.2 ml capacity micro-tubes held in racks of 96 tubes below -180 degrees C for a 20 year period. The archive would be housed in a 900 m(2) industrial unit remote from the main laboratory area that would be generally unmanned and would require a complete cryogenic infrastructure. A commercial supplier was commissioned to provide a complete system including design, project management, supply and installation of all the cryogenic storage requirement including bulk tank, super insulated vacuum lines, Taylor Wharton LABS80K high capacity long-term vapour phase storage vessels with inventory control systems and all the local and remote software. The large-scale storage vessels were selected to give a high storage density, temperature stability and storage in vapour phase.
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http://dx.doi.org/10.1093/ije/dym287 | DOI Listing |
Tree Physiol
September 2025
Linze Inland River Basin Research Station, State Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.
Leaves constitute a vital bottleneck in whole-plant water transport, and their water strategies are key determinants of plant competition and productivity. Nonetheless, our knowledge of leaf water strategies predominantly stems from single perspectives (i.e.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Flavors and Fragrance Engineering & Technology Research Center of Henan Province, College of Tobacco Science, Henan Agricultural University, Zhengzhou 450000, China. Electronic address:
Fragrances are indispensable additives in consumer products including foods, cosmetics, and tobacco products. However, their inherent instability leads to rapid quality degradation and performance loss, driving the urgent need for controlled-release systems to stabilize fragrance performance. In this work, cellulose nanofibers (CNF) were used to prepare CNF aerogel-like gels (CA) and carbonized CNF aerogels (C-CA) through freeze-drying and high-temperature carbonization.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109-5667, United States.
Phase-shift droplets undergoing acoustic droplet vaporization (ADV) offer a promising approach for ultrasound-mediated drug delivery, enabling the spatiotemporally controlled release of therapeutic payloads. A comprehensive understanding of their behavior, through both optical and acoustic methods, is essential for optimizing the therapeutic efficacy. In this study, we investigated the effects of driving pressure, pulse duration, and bulk boiling point of perfluorocarbon droplets on ADV dynamics, payload release, and acoustic emissions.
View Article and Find Full Text PDFCan J Urol
August 2025
Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Florence, 50134, Italy.
Background: The surgical management of patients with benign prostatic hyperplasia (BPH) has considerably evolved through recent years. Nonetheless, benefits and harms of several laser procedures are still to be determined. The study aimed to report perioperative and early functional results of patients treated with anatomical photo vaporization of the prostate (aPVP).
View Article and Find Full Text PDFClin Cancer Res
September 2025
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Purpose: Pretreatment specimens from patients treated on the I-SPY2 neoadjuvant breast cancer trial were studied to identify prespecified biomarkers associated with response to the regimen of paclitaxel, the anti-type I insulin-like growth factor receptor (IGF-1R) antibody ganitumab, and metformin (PGM) followed by doxorubicin and cyclophosphamide (AC) compared with control therapy (paclitaxel followed by AC). The primary endpoint of this trial is pathologic complete response (pCR).
Experimental Design: One hundred six patients treated with PGM and 119 contemporary controls were evaluated using laser capture microdissection and reverse-phase protein array to evaluate 32 prespecified potential predictive biomarkers in the IGF-1R pathway and 109 additional exploratory endpoints.