Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Pamidronate has been studied as a therapeutic drug for various osteopenic diseases. However, avascular osteonecrosis in the jawbone has been recently reported in patients receiving pamidronate. The objective of this study was to examine the effect of pamidronate on bone regeneration in a controlled animal model.
Materials And Methods: To determine the effect of parmidronate on bone healing in a local bony defect area, a rabbit calvarial bony defect model was used and poly L-lactide-co-glycolide (PLGA) used as a drug carrier material. Four defect groups were made in each rabbit calvaria and the defects were treated as follows: untreated bony defect (group 1), PLGA only (group 2), 2 mg of pamidronate with PLGA (group 3), and 3 mg of pamidronate with PLGA (group 4). Bone healing was evaluated by radiography and histology at 1, 2, 4, 6, and 8 weeks after surgery.
Results: In radiographic analysis, radiopacity was lower in pamidronate groups than non-operated rabbit calvarial bone at all observation points (P < .05). In histological analysis, the initial bone formation at 1 week was not different among groups, but it was much lower in the pamidronate groups than in the control or PLGA group after 2 weeks. Newly formed bone at 1 week underwent avascular necrosis after 2 weeks in both pamidronate groups. Avascular necrosis was not observed until 8 weeks in both topically applied pamidronate groups.
Conclusion: Collectively, pamidronate inhibits bone healing in rabbit calvarial bony defect and it may explain the avascular necrosis of the jaws in patients receiving pamidronate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tripleo.2006.06.057 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Temporalis Muscle Flap for Reconstruction Following Lateral Temporal Bone Resection: Anatomical Study and Technical Note.
Clin Anat
September 2025
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
There are no standardized guidelines for reconstructive surgery of large temporal bone defects following lateral temporal bone resection for external auditory (acoustic) meatus carcinoma. Filling the defect with well-vascularized tissue is important for large tissue defects to promote wound healing and prevent infection postoperatively. Patients with malignant tumors of the external acoustic meatus requiring lateral temporal bone resection may sometimes necessitate postoperative adjuvant chemoradiotherapy.
View Article and Find Full Text PDFSenescence-regulating agents remodel mesenchymal stem cell-schwann cell circuitry for diabetic bone regeneration.
Biomaterials
August 2025
Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laborator
Bone healing requires Schwann cells (SCs) paracrine factors for mesenchymal stem cell function. Diabetes mellitus (DM) patients are susceptible to developing SCs dysfunction and impairing bone healing. Rare research considered reconstructing mesenchymal stem cell-schwann cell circuitry in diabetic bone regeneration.
View Article and Find Full Text PDFNanohybrid Hydrogels Spatiotemporally Restore Infectious Bone Defects via Mitochondrial Homeostasis-Driven Immunomodulation and Vascular-Bone Coupling Synergy.
ACS Appl Mater Interfaces
September 2025
Research Center for Nano-Biomaterial, Analytical and Testing Center, Sichuan University, Chengdu 610065, China.
Regeneration of infected bone defects (IBDs) requires biomaterials capable of dynamically coordinating antimicrobial, anti-inflammatory, and osteogenic functions. Overcoming the spatiotemporal mismatches in treating IBDs remains a critical challenge. Here, we designed a temporally controlled therapy based on gelatin methacrylate (GelMA)-based nanocomposite hydrogels (GCS) coembedded with sulfur quantum dots (SQDs) nanoenzymes and calcium-phosphorus oligomers (CPOs.
View Article and Find Full Text PDFRefining Management of Pediatric First Rib Fractures Without Major Trauma.
J Pediatr Surg
September 2025
Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital, 4800 Sand Point Way NE, Ocean 9.A.220, Seattle, WA 98105, USA; Department of Surgery, University of Washington, 1959 Pacific Street, Box 356410, Seattle, WA 98195, USA.
Purpose: First rib fractures in children are typically associated with high-impact trauma; atraumatic etiologies remain understudied. The purpose of this study is to evaluate the presentation and management of pediatric first rib fractures in the absence of major trauma.
Methods: This is a retrospective study of pediatric patients diagnosed with first rib fractures between 2000-2023 at a quaternary, free-standing children's hospital.
Effectiveness of Platelet-Rich Fibrin or Platelet-Rich Plasma in Mandibular Fracture Management: A Systematic Review and Meta-Analysis.
J Stomatol Oral Maxillofac Surg
September 2025
Senior Consultant (Maxillofacial Head and neck Surgery), Dental and Maxillofacial Unit, Bahrain defence force Royal Medical Services, Bahrain.
This systematic review and meta-analysis aimed to critically evaluate and synthesize the available evidence on the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in the management of mandibular and non-mandibular maxillofacial fractures. A comprehensive search of electronic databases was conducted up to February 2025 based on predefined inclusion criteria. The risk of bias in randomized controlled trials was assessed using the Cochrane Risk of Bias (ROB) tool, while the Newcastle-Ottawa Scale was applied to observational studies.
View Article and Find Full Text PDF