Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To observe pathological changes and apoptosis in rats myocardial cells after Macleaya cordata total alkaloids poisoning, and to provide some references for Macleaya cordata total alkaloids poisoning detection.
Methods: An experimental model of Macleaya cordata total alkaloids poisoning was established, and the technology of TUNEL staining was used.The results were analyzed by computer image analysis competitive system.
Results: Quantities of apoptosis in myocardial cells in poisoning groups were much more than those in the control groups at different tages (P<0.01). In addition the quantities of apoptosis were different after different poisoning duration.
Conclusion: Although clinical symptoms was not obvious and could not be detected by poison analysis. Pathological changes induced by Macleaya cordata total alkaloids could be found through the apoptosis detection.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Synergistic effect of oxalic acid and siderophore on uranium fractions and microbial community traits in rhizosphere soil enhances uranium accumulation in plant roots.
Sci Total Environ
September 2025
Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Heng yang 421001, Hunan, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Marine Science, State Key Laboratory for Biocontrol, Sun
Chelating agent contributes to the remediation of heavy metal contaminations, but it remains unclear how they affect the transformation of radioactive pollutants and microbial traits in phytoremediation. We comprehensively investigated on the uranium (U) speciation and microbial communities in the rhizosphere of Macleaya cordata, Paspalum scrobiculatum and Bamboo willow, and analyzed the accumulation of U in the three plants after the addition of chelating agents including 0.1 mmol kg siderophore (DFO) and 2.
View Article and Find Full Text PDFInsights into sanguinarine toxicity in Rats: Integrating toxicokinetics, oxidative stress, and gut microbial alterations.
Regul Toxicol Pharmacol
November 2025
Hunan Province Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China; Chinese Medicinal Materials Breeding Innovation Centre of Yuelushan Laboratory, Changsha, 8 410128, Hunan, China. Electronic address: zeng
Sanguinarine (SAN), a bioactive benzophenanthridine alkaloid derived from Macleaya cordata, has gained attention as a plant-based pesticide and veterinary therapeutic. However, its toxicity mechanisms, particularly concerning toxicokinetics (TK) and gut microbiota interactions, remain poorly understood. This research assessed the acute and subacute toxicity, toxicokinetics, oxidative stress reactions, and changes in gut microbiota associated with SAN in Sprague-Dawley rats.
View Article and Find Full Text PDFInhibitory mechanism of Macleaya cordata crude extracts on freshwater cyanobacterium Microcystis aeruginosa.
J Environ Sci (China)
November 2025
Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
A promising solution to combat harmful cyanobacterial blooms (CyanoHABs) is the use of naturally-derived cyanocidal compound. This study found that the crude extracts of the herbaceous plant Macleaya cordata can inhibit the growth of the bloom-forming cyanobacterium Microcystis aeruginosa. Growth inhibition test suggested that the inhibitory effect was significant at a concentration as low as 5 µg/L of the crude extracts.
View Article and Find Full Text PDFExploring biosynthetic potential of the endophytic BLH34 using whole-genome sequence analysis and molecular networking.
Nat Prod Res
May 2025
School of Plant Protection, Anhui Agricultural University, Hefei, Anhui Province, China.
An in-depth genomic and metabolomic investigation was conducted on the endophytic fungus BLH34, isolated from . Hybrid sequencing (Illumina-Nanopore) generated a high-quality 27.9 Mb genome (GC 48.
View Article and Find Full Text PDFBioactive natural alkaloid 6-Methoxydihydrosanguinarine exerts anti-tumor effects in hepatocellular carcinoma cells via ferroptosis.
Front Pharmacol
April 2025
The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Nutrition, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Introduction: Ferroptosis is a form of regulated cell death driven by the accumulation of iron-dependent lipid peroxides, and ferroptosis-mediated cancer therapy has gained considerable attention. Despite emerging evidence that ferroptosis induction effectively suppresses hepatocellular carcinoma (HCC) progression and enhances chemosensitivity, the development of resistance to ferroptosis-targeting therapies remains a critical challenge. Natural active compounds have great potential in cancer treatment.
View Article and Find Full Text PDF