Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Monodispersed poly(N-isopropylacrylamide) submicrometric microgels modified with a phenylboronic acid (PBA) derivative have been synthesized by precipitation polymerization. Particles with a well-controlled size and adjustable composition were obtained. These particles were found to be glucose responsive at a pH close to the pKa of the PBA derivative, with a swelling degree proportional to the concentration of glucose. In addition, the response to glucose was found to strongly depend on the initial state of the microgel, which depended itself on the initial temperature and the functionalization degree of the particle. This result explained the fundamental difference in the behavior of PBA-poor particles and rich ones in the presence of electrolyte. Interestingly, the latter exhibited a high swelling ratio in the presence of glucose at physiological electrolyte concentration. These particles may serve as building blocks for the design of colorimetric sensors based on the light diffraction of colloidal crystals.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/bm060588n | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Essential Oil-Antibiotics Synergistic Delivery Strategy via Phenylboronic-Acid-Functionalized Liposomes for Targeted Treatment of MRSA Pneumonia.
ACS Infect Dis
September 2025
The Department of Pharmaceutics of TCM (The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability, the Union Key Laboratory of Guiyang City-Guizhou Medical University), School of Pharmaceutical Sciences, Guizhou Medical University, Guian New District
Methicillin-resistant (MRSA)-induced pneumonia has become a major global public health challenge due to its high mortality and drug resistance. Essential oils, derived from plants, offer a promising solution to combat resistance owing to their low cytotoxicity and multitarget antimicrobial properties. This study designed a phenylboronic acid (PBA)-functionalized liposomal codelivery system (P-Lip@CE) to reverse MRSA resistance by synergistically delivering cefazolin sodium (Cefas) and essential oil (EOFAZ).
View Article and Find Full Text PDFTLR9/NF-κB-mediated dendritic cell activation by neutrophil extracellular traps drives pathogenesis in experimental cerebral malaria.
J Neuroinflammation
August 2025
Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang City, Liaoning Province, 110122, P.R. China.
Cerebral malaria (CM) is the most severe complication of Plasmodium falciparum infection, and accounts for the majority of malaria-associated mortality. Reducing the overwhelming inflammatory responses in the early stage of infection is a key point to prevent death due to CM. In this study, we found that neutrophil mobilization occurred rapidly in response to Plasmodium berghei ANKA (PbA) infection in a murine CM model.
View Article and Find Full Text PDFConstruction of Active-Passive Dual-Targeted Drug-Loaded Micelle Nanoparticles with Modified Dopamine Molecules for Efficient Anti-Tumor Therapy.
Int J Nanomedicine
August 2025
School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458, People's Republic of China.
Purpose: This study designed a dopamine derivative integrating active targeting and pH-responsive borate ester bond-mediated passive targeting to construct drug delivery systems for tumor-targeted drug delivery, thus improving antitumor drug bioavailability and expanding the application of dopamine in drug delivery.
Methods: Nuclear magnetic resonance and Fourier transform infrared spectrometry were used to determine the structures of Man-PBA-DAO and Man-2PBA-DAO. Hydrodynamic diameter measurements confirmed the pH responsiveness of the targeting nanoparticles in different pH media over 12 hours.
Dual Keap1-Dependent actions of pubescenoside A against ulcerative colitis: Promoting DDX5 ubiquitination degradation and Nrf2 nuclear translocation to suppress inflammation.
Free Radic Biol Med
August 2025
Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, State Key Laborator
Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon, characterized by a complex clinical syndrome. Pubescenoside A (PBA), a phenylpropanoid derived from Ilex pubescens, exhibits significant anti-inflammatory effects; however, the impact and underlying mechanism of PBA on UC remain unclear. Therefore, the aim of this study is to investigate the potential mechanism of PBA against UC using in vivo and in vitro experiments.
View Article and Find Full Text PDFFast Screening of Circulating Tumor Cells in Blood Samples by Sialic Acid Recognition and Microfluidic Chip-Single-Cell ICP-MS: A Breakthrough in Non-invasive Cancer Diagnosis.
Anal Chem
September 2025
Department of Chemistry, Wuhan University, Wuhan 430072, China.
Circulating tumor cells (CTCs) hold promise for non-invasive cancer diagnostics, but current detection methods face challenges like white blood cell (WBC) interference, high false negative rates, low throughput, and operational complexity. To overcome these, we developed a simple, fast, and universal CTCs analysis method by the integrating sialic acid (SA) recognition strategy, microfluidic cell sorting, and online single-cell inductively coupled plasma mass spectrometry (SC-ICP-MS) detection. Cells from lysed blood sample were labeled by phenylboronic acid-functionalized gold nanoparticles (PBA-AuNPs) via PBA-SA recognition.
View Article and Find Full Text PDF