Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The reversible condensation of chromosomes during cell division remains a classic problem in cell biology. Condensation requires the condensin complex in certain experimental systems, but not in many others. Anaphase chromosome segregation almost always fails in condensin-depleted cells, leading to the formation of prominent chromatin bridges and cytokinesis failure. Here, live-cell analysis of chicken DT40 cells bearing a conditional knockout of condensin subunit SMC2 revealed that condensin-depleted chromosomes abruptly lose their compact architecture during anaphase and form massive chromatin bridges. The compact chromosome structure can be preserved and anaphase chromosome segregation rescued by preventing the targeting subunit Repo-Man from recruiting protein phosphatase 1 (PP1) to chromatin at anaphase onset. This study identifies an activity critical for mitotic chromosome structure that is inactivated by Repo-Man-PP1 during anaphase. This activity, provisionally termed 'regulator of chromosome architecture' (RCA), cooperates with condensin to preserve the characteristic chromosome architecture during mitosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741681 | PMC |
| http://dx.doi.org/10.1038/ncb1475 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Haplotype-resolved genomes of reveal nuclear differentiation, TE-mediated variation, and saprotrophic potential.
IMA Fungus
August 2025
State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China Institute of Microbiology, Chinese Academy of Sciences Beijing China.
is a widely consumed edible mushroom and the only species currently cultivated on an industrial scale. Despite its economic importance, its trophic strategy and genomic adaptations remain elusive. Here, we presented high-quality, chromosome-level genome assemblies for two sexually compatible monokaryons (PP78 and PP85) of .
View Article and Find Full Text PDFA Bird's-Eye View of the Wings Apart-Like Protein in Cell Biology and Implications for Disease and Therapeutics.
OMICS
September 2025
Centre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, India.
Wings apart-like protein (WAPL) has emerged as a key player in maintaining genome integrity through its regulation of cohesin dynamics, which govern chromatin architecture and gene expression. WAPL mainly acts as a cohesin release factor and ensures proper chromosomal segregation during mitosis by promoting sister chromatid resolution. Owing to its prominent role in cell biology, WAPL dysregulation can cause genomic instability and disrupt chromosomal cohesion, leading to diseases such as cancer.
View Article and Find Full Text PDFGenetic architecture of the S-locus supergene revealed in a tetraploid distylous species.
New Phytol
September 2025
State Key Laboratory of Plant Diversity and Specialty Crops/Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China.
Heterostyly is a polymorphic floral adaptation controlled by supergenes. The molecular basis of distyly has been investigated in diploid species from several unrelated families, but information is lacking for polyploid systems. Here, we address this knowledge gap in Schizomussaenda henryi, a tetraploid distylous species of Rubiaceae, the family with the greatest number of heterostylous species.
View Article and Find Full Text PDFBeyond supergenes: the diverse roles of inversions in trait evolution.
Trends Ecol Evol
September 2025
GEOMAR Helmholtz Centre for Ocean Research Kiel, Marine Evolutionary Ecology, Kiel, Germany.
Chromosomal inversions are ubiquitous across the Tree of Life, with genome-wide studies revealing a bias toward smaller inversions, yet research has disproportionately focused on large, supergene-like inversions linked to discrete phenotypes. This limits our understanding of inversions' roles in trait evolution, as their size affects their potential functional impact. Investigation of smaller inversions and multi-inversion genotypes is crucial to elucidate their role in shaping continuous traits and evolutionary adaptation.
View Article and Find Full Text PDFThe genomics of discrete polymorphisms maintained by disruptive selection.
Trends Ecol Evol
September 2025
Genetics Course, Graduate University for Advanced Studies, Mishima, Shizuoka, Japan; Theoretical Ecology and Evolution Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan.
Disruptive selection can lead to the evolution of discrete morphs. We show that particular genetic architectures, in terms of dominance, epistasis, and linkage, are likely to evolve to produce discrete morphs under disruptive selection. Recent genomic studies have revealed that causative mutations tend to cluster, sometimes as a result of chromosomal rearrangements, but we still know little about the molecular mechanisms of dominance and epistasis.
View Article and Find Full Text PDF