Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: CD40/CD40L signaling is known to play an important role in immune response. The proteins are expressed in a variety of cell types and ligation causes cells to produce inflammatory cytokines and cellular adhesion molecules. These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion.
Methods: We investigated the role of genetic variation in CD40 and CD40L genes in subclinical atherosclerosis assessed by coronary artery calcification (CAC) and carotid intima-media thickness in 620 individuals from 230 families in the DHS.
Results: Two single nucleotide polymorphisms in the CD40 gene (rs1535045 and rs3765459) were significantly associated with decreased CAC (P < or = .02) in this population. CD40L single nucleotide polymorphisms were not significantly associated. In addition, no associations with carotid intima-media thickness, carotid artery calcification, or C-reactive protein levels were detected for either gene.
Conclusion: Genetic variation in the CD40 gene is associated with CAC in diabetic families.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ahj.2005.05.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Effects of Pseudostellaria heterophylla Polysaccharide on Humoral Immunity and Gene Expression of Splenic Lymphocytes in Chicks.
Dev Comp Immunol
September 2025
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China. Electronic address:
This study aimed to evaluate the effects of dietary Pseudostellaria heterophylla Polysaccharide (PHP) on humoral immunity and spleen lymphocyte gene expression in chicks. A total of 270 one-day-old healthy Gushi chicks were randomly allocated into three groups: Group A was fed the basic diet without vaccination; Group B received the basic diet and underwent immunization; Group C was provided with the basic diet supplemented with 200 mg/kg PHP, coupled with immunization. Samples were collected at 7, 14, 21, 28, 35, 42, and 49 days.
View Article and Find Full Text PDFDevelopment of an in vitro method to assess the immunogenicity of biologics in the prevention of infectious diseases.
Immunol Res
September 2025
Centre for Advanced Materials and Technologies, Warsaw University of Technology, Warsaw, Poland.
We present a series of preclinical studies focused on developing in vitro 2D and 3D models for assessing immunogenic factors in preventing infectious diseases. Human peripheral blood mononuclear cells (PBMC) and Calu-3 cell lines (bronchial epithelial cells) were used to develop 2D and 3D models. Peptides: Spike-S1-His (S-His), nucleocapsid-His and adjuvants: human adenovirus five serotype-based viral vector (AdV-D24-ICOSL-CD40L), armed with inducible co-stimulator (ICOSL) and CD40 ligand (CD40L), and a vector lacking these transgenes (AdV5/3) were used due to their effective initial interaction with antigen-presenting cells (APC).
View Article and Find Full Text PDFinhibits doxorubicin-induced macrophage maturation and apoptosis through mTOR signaling in classical Hodgkin lymphoma.
Iran J Basic Med Sci
January 2025
Institute of Biology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Objectives: Classical Hodgkin lymphoma (cHL) is identified by the appearance of Hodgkin and Reed-Sternberg cells. and are deubiquitinating enzymes involved in negatively regulating NF-κB-mediated immune response. Vincristine (Vinc) and doxorubicin (Dox) are classical antitumor drugs, in which Dox serves a key role in chemotherapy against cHL and Vinc induces disruption of microtubule function that inhibits mitosis of cancer cells.
View Article and Find Full Text PDFAnti-Inflammatory Effects of L. Polysaccharide and Its Limited Gene Expression Profile.
Int J Mol Sci
August 2025
Faculty of Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Previous studies have demonstrated that L. polysaccharide (HTLP) exhibits potent immunomodulating activity. The aim of this study was to investigate the molecular mechanisms underlying this activity and explore its potential applications in various anti-inflammatory models.
View Article and Find Full Text PDFCharacterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma.
Cancer Gene Ther
August 2025
Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a dismal prognosis. Hitherto, little has been known regarding the clinical implications of tertiary lymphoid structures (TLS) and its biological mechanisms of antitumor effect on treatment-naïve ESCC. We herein identified the presence of TLS as an independent factor for favorable survival.
View Article and Find Full Text PDF