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Although many distortion-product otoacoustic emissions (DPOAEs) may be measured in the ear canal in response to 2 pure tone stimuli, the majority of clinical studies have focused exclusively on the DPOAE at the frequency 2f1-f2. This study investigated another DPOAE, 2f2-f1, in an attempt to determine the following: (a) the optimal stimulus parameters for its clinical measurement and (b) its utility in differentiating between normal-hearing and hearing-impaired ears at low-to-mid frequencies (
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http://dx.doi.org/10.1044/1092-4388(2005/082) DOI Listing Publication Analysis
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Ear Hear
September 2025
Department of Otolaryngology, Head and Neck Surgery, Kyushu University, Fukuoka, Japan.
Objectives: This study aimed to investigate the potential contribution of subtle peripheral auditory dysfunction to listening difficulties (LiD) using a threshold-equalizing noise (TEN) test and distortion-product otoacoustic emissions (DPOAE). We hypothesized that a subset of patients with LiD have undetectable peripheral auditory dysfunction.
Design: This case-control study included 61 patients (12 to 53 years old; male/female, 18/43) in the LiD group and 22 volunteers (12 to 59 years old; male/female, 10/12) in the control group.
Neuroscience
September 2025
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Electronic address:
The auditory brainstem response (ABR) remains the gold standard for evaluating hearing function in both animal models and humans. Features of ABR, including threshold, wave I amplitude and latency are critical for diagnosing and investigating the mechanisms of hearing loss. Critically, the rapid proliferation of genetically engineered mouse models in hearing research has created an imperative demand for high-throughput ABR testing capabilities.
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August 2025
Department of Otolaryngology, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Objective: To characterize the transition of audiometric features in patients with inner ear schwannoma (IES) with a special focus on transient mixed hearing loss.
Patients: Twelve patients were clinically diagnosed with an IES.
Interventions: All patients underwent otoscopic and audiological examinations, including serial pure-tone audiometry and magnetic resonance imaging (MRI) scans.
Ear Hear
September 2025
Department of Information Technology - Hearing Technology @Waves, Ghent University, Ghent, Belgium.
Objectives: Platinum-based chemotherapy, cisplatin as well as carboplatin, can cause ototoxicity, which refers to drug-related damage affecting inner ear structures. At present, most ototoxicity monitoring programs rely on pure-tone audiometry, which is inadequate for detecting early outer hair cell (OHC) damage. Recent animal studies have shown that platinum derivatives can damage auditory nerve fibers (ANF), leading to cochlear synaptopathy (CS).
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August 2025
School of Computer and Communication Engineering, Beijing Advanced Innovation Center for Materials Genome Engineering, University of Science and Technology Beijing, Beijing, China.
Objectives: The prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL) is heterogeneous. The study aimed to investigate the prognostic factors of ISSNHL and develop machine-learning models with multiple imputation to predict the prognosis of ISSNHL.
Design: A retrospective study was undertaken on a cohort of 600 patients with ISSNHL who underwent standardized treatment protocols.