Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background And Purpose: To evaluate intraoperative brachytherapy in the management of soft tissue sarcomas involving neurovascular structures, its impact on local control and complications.
Patients And Methods: Between 01/1989 and 12/2002, 98 patients received an intraoperative implant in conjunction with conservative surgery. Brachytherapy was part of the initial treatment (79 cases) or performed in recurrent disease (19 cases). We studied primary sarcomas involving neurovascular structures treated with conservative surgery and intraoperative brachytherapy (n = 6) or intraoperative brachytherapy and external irradiation (n = 73). Conservative surgery was performed as first treatment (51 cases), after chemotherapy (21 cases) and after primary external radiation (seven cases). Brachytherapy was performed according to Paris system rules. Patients were loaded with Iridium 192 (64 cases) or connected to a Microselectron PDR (15 cases). Mean dose given by brachytherapy was 20 Gy. Mean dose given of external radiotherapy was 46 Gy.
Results: With a median follow-up of 58 months, 5-year actuarial survival was 69% and local free disease at 5 years was 90%. Acute side-effects occurred in 22/79 requiring surgical repair in 10 patients. Late side-effects occurred in 35/79. No patient required amputation for complications. Prognostic factors were studied for the occurrence of acute and late side-effects and local control.
Conclusions: Intraoperative brachytherapy is efficient with excellent local control rates in soft tissue sarcomas presenting with neurovascular involvement and offers an acceptable conservative option.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.radonc.2005.12.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intraoperative low-dose rate brachytherapy as an adjunct to surgery for marginally resectable rectal and recurrent anorectal carcinomas.
Brachytherapy
August 2025
Brigham and Women's Hospital, Boston, MA; Dana Farber Cancer Institute, Boston, MA; Harvard Medical School, Boston, MA.
Background: Locally recurrent and marginally resectable rectal and anorectal carcinomas present significant therapeutic challenges due to high recurrence rates and limited treatment options. Intraoperative low-dose rate brachytherapy (LDRBT) has emerged as a potential adjunct to improve local control in these cases. This study aims to evaluate the clinical outcomes associated with intraoperative LDRBT for these difficult cases.
View Article and Find Full Text PDFA biologically effective dose-based framework for integrating LDR brachytherapy and EBRT in glioblastoma treatment.
Brachytherapy
August 2025
Department of Medical Affairs, GT Medical Technologies, Inc., Tempe, AZ.
Purpose: Radiation therapy is a core component of the standard of care (SOC) for glioblastoma (GBM), yet outcomes remain poor. Rapid early progression (REP) between maximal safe resection and start of external beam radiation therapy (EBRT) is associated with reduced survival. The GESTALT trial (NCT05342883) investigates whether initiating low-dose-rate brachytherapy (LDRBT) at time of resection can mitigate rates of REP prior to EBRT.
View Article and Find Full Text PDFIterative intraoperative 3T MRI (iMRI)-guided brachytherapy: A prospective study on enhancing implantation precision and dosimetric gains in advanced gynecologic cancers.
Brachytherapy
August 2025
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, USA.
Purpose: To report on primary outcomes and dosimetric results of a prospective clinical trial and protocol for use of iterative intraoperative magnetic resonance imaging (iMRI) in gynecologic brachytherapy.
Methods: Patients with locally advanced cervical or vaginal cancer (FIGO stages IB2 - IVA, and stage II-IVA, respectively) undergoing pulsed dose rate (PDR) brachytherapy were enrolled in a prospective clinical trial (NCT03634267) using iterative 3T iMRI during brachytherapy implant placement. Applicator and optional interstitial needles were placed under iMRI guidance in a 3T clinical MRI scanner.
Research on prostate brachytherapy puncture control strategy based on adaptive PID control with FBG sensors.
PLoS One
August 2025
Automation College, Wuxi University, Wuxi, China.
This paper enhances prostate brachytherapy robot accuracy by developing a needle deflection prediction model and a controlled puncturing strategy, addressing current challenges and trends. The study addresses the challenges in needle deflection prediction by proposing a correction force-based prediction model. The puncture control strategy comprises two phases: preoperative needle trajectory planning and intraoperative approach adjustment, both relying on corrective force.
View Article and Find Full Text PDFIntra-operative process efficiency for in-room MRI-guided combined intracavitary/interstitial brachytherapy for cervical cancer.
Brachytherapy
August 2025
Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Purpose: Magnetic resonance image-guided brachytherapy (MRgBT) is the gold-standard treatment for cervical cancer. This study examined workflow times in an integrated MRgBT suite and conventional operating room (OR), and factors contributing to intraoperative efficiency.
Methods And Materials: Consecutive patients with FIGO stage IB-IVA cervical cancer who underwent MRgBT procedures between 2019-2022 were retrospectively reviewed.