Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Neurosteroids are synthesized de novo and involved in a variety of physiological functions in the central and peripheral nervous systems. Although the steroidogenic acute regulatory protein (StAR) plays an essential role in the steroidogenesis of peripheral endocrine glands, its presence and role in the brain had been previously questioned because of difficulties in detecting it. However, a number of recent studies have confirmed the presence of StAR in rodent and human brains. Moreover, there is evidence suggesting that StAR plays a role in steroidogenesis in the brain, as it does in peripheral endocrine organs. The present review presents data regarding the presence and role of StAR in brain steroidogenesis, demonstrating the essential characteristics of the protein.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1679/aohc.67.383 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Role of StAR Gene in Sex Steroid Hormone Regulation and Gonadal Development in Ark Shell .
Biology (Basel)
July 2025
State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
This study elucidates the role of the () in sex steroid hormone dynamics and the gonadal development of the commercially important marine bivalve ark shell . The sequence of the gene was obtained and verified from the transcriptome of ark shell, then the tissue localization and expression pattern during the gonad development of the gene were detected by in situ hybridization and quantitative real-time PCR, respectively. Additionally, the concentrations of three critical sex steroid hormones (progesterone, testosterone, and estradiol) were measured throughout gonadal development using enzyme-linked immunosorbent assay (ELISA).
View Article and Find Full Text PDFInsights into the STARD family in arthropods: Genome-wide identification, evolutionary analysis and expression patterns.
Comp Biochem Physiol Part D Genomics Proteomics
August 2025
Centre for Research on Environmental Ecology and Fish Nutrition of the Ministry of Agriculture and Rural Affairs of China, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Freshwater Aquatic Genetic Resources Certified by the Ministry of Agriculture and Rural Affairs of China, Sh
Steroidogenic acute regulatory domain (STARD) protein family plays a crucial role in cholesterol and carotenoids transport; however, little is known about their evolution history, gene structure and potential ligands in arthropods. This study comprehensively investigated the STARD family in crustaceans, focusing on phylogenetic relationships, evolutionary dynamics, ligand preferences, and expression patterns in the Chinese mitten crab Eriocheir sinensis. In total, 196 STARD genes were identified across 34 representative arthropods, and the STARD1/3 alternative was exhibited in most arthropods.
View Article and Find Full Text PDFAdverse Event Profile Differences Between Metyrapone and Osilodrostat: A Pharmacovigilance Study of the FDA Adverse Event Reporting System.
Horm Metab Res
August 2025
Department of Pharmacy, Guang'an People's Hospital, Sichuan, China.
Metyrapone and osilodrostat are both steroidogenic inhibitors targeting the 11β-hydroxylase, yet their safety profile has not been comprehensively analyzed. The objective of this study is to compare the adverse events (AEs) associated with osilodrostat and metyrapone based on the Food and Drug Administration Adverse Event Reporting System (FAERS). AEs were classified according to the System Organ Class (SOC) in the Medical Dictionary for Regulatory Activities (MedDRA) version 26.
View Article and Find Full Text PDFEvaluation of Serum STARD3 Levels in Patients With Breast and Prostate Cancer: A Case-Control Study.
Eur J Breast Health
August 2025
Department of Medical Biology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Türkiye.
Objective: Cancer cells exhibit high metabolic demands and rely heavily on lipid metabolism for proliferation and membrane synthesis. Lipid transfer proteins, particularly the steroidogenic acute regulatory-related lipid transfer domain 3 (STARD3), play a significant role in intracellular cholesterol transport and may influence cancer progression. The aim of this study was to investigate serum STARD3 levels in patients with breast and prostate cancer and compare them with healthy controls, along with lipid parameters.
View Article and Find Full Text PDFTransport of cholesterol to ovary via the Srb selective uptake pathway supports Star-mediated steroidogenesis in swimming crab (Portunus trituberculatus).
J Nutr Biochem
August 2025
Laboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China; Key Laboratory of Aquaculture Biotechnology Ministry of Education, Ningbo University, Ningbo, 315211, China; Key Laboratory of Green Mariculture (Co-construction by Ministry and Province),
Cholesterol, essential for steroidogenesis, is crucial in ovarian development. In crustaceans, scavenger receptor class B member (Srb) and steroidogenic acute regulatory protein (Star) may be key proteins in cholesterol transport and steroidogenesis, respectively. This study aimed to explore cholesterol's role in steroidogenesis and ovarian development in female swimming crabs through in vivo and in vitro experiments.
View Article and Find Full Text PDF