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Gall bladder sludge and biliary pseudolithiasis as rare complications of ceftriaxone therapy in adult patients - A case report including sonographic workup.
Eur J Microbiol Immunol (Bp)
August 2025
5Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany.
Background: Ceftriaxone-induced biliary pseudolithiasis is a disease entity frequently observed in children, while it is rarely seen in adult patients. We provide a thorough sonographic workup of the case to guide sonographers confronted with it.
Case Report: A 41-years-old male patient with sonographically confirmed, culture-negative endocarditis accompanied by repeated fever episodes received 4g ceftriaxone per day next to ampicillin and gentamicin as an element of his antibiotic therapy.
Ceftriaxone-induced cholestatic hepatitis in a child: A case report and a review of the literature.
Front Pediatr
December 2022
Pediatric Intermediate Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Ceftriaxone, a third-generation cephalosporin, is commonly used in pediatric patients and is generally well tolerated. Its more frequent adverse effects are biliary pseudolithiasis, urolithiasis, and hemolytic anemia. On the other hand, ceftriaxone-induced acute cholestatic hepatitis is a very rare condition, especially in children.
View Article and Find Full Text PDFAcute necrotizing calculous cholecystitis after treatment with ceftriaxone in an elderly patient: a case report.
Surg Case Rep
May 2022
Department of Surgery, Doshinkai Tohyama Hospital, Minami-Shinmachi 17-22, Tsu, Mie, 514-0043, Japan.
Background: Ceftriaxone, a third-generation cephalosporin antibiotic with a long plasma half-life, is widely used to treat various infections. The use of ceftriaxone can sometimes induce biliary sludge or stone formation. Although most cases of ceftriaxone-induced pseudolithiasis are asymptomatic or mild and resolve with discontinuation of the drug, we experienced an elderly case of severe acute necrotizing calculous cholecystitis after administration of ceftriaxone.
View Article and Find Full Text PDFRapid Onset of Ceftriaxone-Induced Cholelithiasis in an Adult Patient.
J Glob Infect Dis
February 2022
Campbellton Regional Hospital, Vitalité Health Network, New Brunswick, Canada.
Article Synopsis
- - Ceftriaxone, a broad-spectrum antibiotic, was administered to a 57-year-old female for meningitis, but led to complications with cholelithiasis (gallstones) after a short treatment period.
- - Her liver function tests showed elevated transaminases, and imaging confirmed the presence of gallstones; treatment was switched to cefotaxime after discontinuing ceftriaxone, resulting in improved liver function.
- - This case emphasizes that ceftriaxone-induced cholelithiasis can occur in adults even with short-term use, contrasting previous reports mainly focused on children or prolonged use.
Ceftriaxone-induced Acute Cholecystitis.
J Med Ultrasound
May 2021
Department of Radiology, Hospital de Braga, Braga, Portugal.
Ceftriaxone has been increasingly used in pediatric population, due to its bacteriological and pharmacokinetic features. Association between ceftriaxone and biliary sludge/pseudolithiasis formation has been documented in the literature. More rarely, biliary symptoms and cholecystitis during ceftriaxone therapy have been reported.
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