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A facile method for the synthesis of 3'-alpha-fluoro-2',3'-dideoxyadenosine (5) has been developed using a novel rearrangement of 3'-beta-bromine to the 2'-beta position during 3'-alpha fluorination.
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http://dx.doi.org/10.1081/NCN-120022616 | DOI Listing |
Nat Commun
September 2025
Life-Like Materials and Systems, University of Mainz, Mainz, Germany.
Nuclear biomolecular condensates are essential sub-compartments within the cell nucleus and play key roles in transcription and RNA processing. Bottom-up construction of nuclear architectures in synthetic settings is non-trivial but vital for understanding the mechanisms of condensates in real cellular systems. Here, we present a facile and versatile synthetic DNA protonucleus (PN) platform that facilitates localized transcription of branched RNA motifs with kissing loops (KLs) for subsequent condensation into complex condensate architectures.
View Article and Find Full Text PDFMater Horiz
September 2025
College of Polymer Science and Engineering, Sichuan University, State Key Laboratory of Advanced Polymer Materials, Chengdu, 610065, Sichuan, China.
Mechanical stimuli-responsive shape transformations, exemplified by mimosa leaves, are widespread in nature, yet remain challenging to realize through facile fabrication in synthetic morphing materials. Herein, we demonstrate stretch-activated shape-morphing enabled by an elastic-plastic bilayer structure assembled dynamic crosslinking. Through dioxaborolane metathesis, a dynamic, crosslinked polyolefin elastomer (POEV) with elasticity and a co-crosslinked POE/paraffin wax blend (POE/PW-V) with tunable plasticity are prepared.
View Article and Find Full Text PDFOrg Biomol Chem
September 2025
Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune-410008, India.
A facile and efficient one-pot rongalite-mediated self-dimerization of 3-acylidene-2-oxindoles has been developed for the diastereoselective synthesis of highly functionalized dispirocyclopentanebisoxindoles. The reaction proceeds a domino sequence involving intermolecular Michael addition followed by intramolecular aldol cyclization under basic conditions. Rongalite, an inexpensive and readily available reagent (∼$0.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Department of Chemistry, Rutgers University-Newark, Newark, New Jersey 07102, United States.
Carbon-hydrogen bond activation is a pillar of synthetic chemistry. While it is generally accepted that Pd is more facile than Ni in C-H activation catalysis, there are no experimental platforms available to directly compare the magnitude of C-H bond weakening between Ni and Pd prior to bond scission. This work presents the first direct measurements of C(sp)-H bond acidity (p) and bond dissociation free energy (BDFE) for a species containing a ligated alkane-palladium interaction (RCH···Pd), also known as an agostic interaction.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
Computational Inorganic Chemistry Group, Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana 502284, India.
Over the past few years, alkali and alkaline earth metals have emerged as alternative catalysts to transition metal organometallics to catalyze the hydroboration of unsaturated compounds. A highly selective and cost-effective lithium-catalyzed method for the synthesis of an organoborane has been established based on the addition of a B-H bond to an unsaturated bond (polarized or unpolarized) using pinacolborane (HBPin). In the present work, the neosilyllithium-catalyzed hydroboration of nitriles, aldehydes, and esters has been investigated using high-level DLPNO-CCSD(T) calculations to unravel the mechanistic pathways and substrate-dependent reactivity.
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