Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To study the role of lethal gene: including retinoic X receptor (RXR)alpha, N-myc and transcript enhancer factor (TEF)-1 in human spontaneous abortion.
Methods: The levels of RXRalpha, N-myc and TEF-1 mRNA expression on placenta villi from 38 spontaneous abortion women and 33 normal early pregnant women were examined by reverse transcription, polymerase chain reaction.
Results: (1) The levels of RXRalpha mRNA on placenta villi from the abortion group were significantly decreased as compared with those from normal group (0.4 +/- 0.3 versus 0.6 +/- 0.3, P < 0.05); There were no significant differences in the levels of N-myc mRNA expression between the abortion group and normal group (2.1 +/- 1.2 versus 2.2 +/- 0.9, P > 0.05). The levels of TEF-1 mRNA on placenta from abortion group were significantly lower than those from normal group (1.6 +/- 1.1, 2.3 +/- 1.2, P < 0.05); (2) The levels of RXR alpha mRNA, TEF-1 mRNA in recurrent abortion group were significantly lower than those from non-recurrent group (0.3 +/- 0.2 versus 0.6 +/- 0.4, P < 0.05, 1.0 +/- 1.1 versus 1.9 +/- 1.2, P < 0.05).
Conclusion: It was suggested that the lower expression of RXR alpha mRNA, TEF-1 mRNA may play an important role in the pathogenesis of spontaneous abortion especially in recurrent abortion.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Stress-Responsive Gene FK506-Binding Protein 51 Mediates Alcohol-Induced Liver Injury Through the Hippo Pathway and Chemokine (C-X-C Motif) Ligand 1 Signaling.
Hepatology
September 2021
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Background And Aims: Chronic alcohol drinking is a major risk factor for alcohol-associated liver disease (ALD). FK506-binding protein 51 (FKBP5), a cochaperone protein, is involved in many key regulatory pathways. It is known to be involved in stress-related disorders, but there are no reports regarding its role in ALD.
View Article and Find Full Text PDF9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.
Circulation
November 2015
From Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ontario, Canada (N.A.M.A., D.A., R.O.V., S.X.Z., K.N.H., A.F.R.S.); Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ontario, Canada (N.A.M.A., D.A., R.O.V., A.F.R.S.); Center for
Background: The mechanism whereby the 9p21.3 locus confers risk for coronary artery disease remains incompletely understood. Risk alleles are associated with reduced expression of the cell cycle suppressor genes CDKN2A (p16 and p14) and CDKN2B (p15) and increased vascular smooth muscle cell proliferation.
View Article and Find Full Text PDFGenome-wide progesterone receptor binding: cell type-specific and shared mechanisms in T47D breast cancer cells and primary leiomyoma cells.
PLoS One
June 2012
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Background: Progesterone, via its nuclear receptor (PR), exerts an overall tumorigenic effect on both uterine fibroid (leiomyoma) and breast cancer tissues, whereas the antiprogestin RU486 inhibits growth of these tissues through an unknown mechanism. Here, we determined the interaction between common or cell-specific genome-wide binding sites of PR and mRNA expression in RU486-treated uterine leiomyoma and breast cancer cells.
Principal Findings: ChIP-sequencing revealed 31,457 and 7,034 PR-binding sites in breast cancer and uterine leiomyoma cells, respectively; 1,035 sites overlapped in both cell types.
Rapid muscle atrophy response to unloading: pretranslational processes involving MHC and actin.
J Appl Physiol (1985)
October 2009
Departmentof Physiology and Biophysics, Univ. of California, Irvine, D-346, Med. Sci. I, Irvine, CA 92697, USA.
Skeletal muscles, especially weight-bearing muscles, are very sensitive to changes in loading state. The aim of this paper was to characterize the dynamic changes in the unloaded soleus muscle in vivo following a short bout of hindlimb suspension (HS), testing the hypothesis that transcriptional events respond early to the atrophic stimulus. In fact, we observed that after only 1 day of HS, primary transcript levels of skeletal alpha-actin and type I myosin heavy chain (MHC) genes were significantly reduced by more than 50% compared with ground control levels.
View Article and Find Full Text PDFCellular factors are required to activate bovine papillomavirus-1 early gene transcription and to establish viral plasmid persistence but are not required for cellular transformation.
Virology
June 2009
Veterans Affairs Medical Center, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Transcription from the major upstream early gene promoter, P89, of bovine papillomavirus (BPV)-1 is detectable in transfected cells lacking viral gene products yet also responds to viral E2 proteins. In contrast to human papillomaviruses (HPVs), the BPV upstream regulatory region (URR) functions as a transcriptional enhancer in epithelial cells and fibroblasts of bovine, murine or human origin. Mutations of Sp1 and/or two novel transcriptional enhancer factor (TEF)-1 sites within the 5' URR of the intact BPV-1 genome dramatically reduced P89-initiated mRNA levels, leading to decreased BPV-1 plasmid amplification and inefficient formation of transformed cell foci.
View Article and Find Full Text PDF