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http://dx.doi.org/10.1021/cr960421s | DOI Listing |
Environ Sci Technol
September 2025
Institute IWAR, Chair of Environmental Analytics and Pollutants, Technical University of Darmstadt, Franziska-Braun-Straße 7, D-64287 Darmstadt, Germany.
Chlorine dioxide (ClO) is used for disinfection and preoxidation in water treatment, often as an alternative to free available chlorine (FAC) to reduce the formation of halogenated byproducts. However, the latest research has shown that FAC can be formed as a secondary oxidant in the ClO reaction with activated aromatic compounds, such as phenols. In this study, the reaction of ClO with aromatic nitrogen-containing heterocycles (NCHs) is investigated as another possible FAC precursor.
View Article and Find Full Text PDFACS Chem Biol
August 2025
Department of Chemistry, University of Colorado Denver, Science Building 1151 Arapahoe Street, Denver, Colorado 80204, United States.
The use of nucleic acids as potential therapeutic tools, sensors, or biomaterials, among other applications, has dramatically increased. Among these, RNA aptamers are of interest due to an innate high specificity toward their cognate targets, which include small molecules, proteins, ions, or cells. In this work, we took advantage of the ability that 8-oxo-7,8-dihydroguanine (8-oxoG) has to participate in unique H-bonding interactions, and probed its use to increase/control the selectivity/affinity of aptamers of RNA and DNA.
View Article and Find Full Text PDFJ Am Chem Soc
August 2025
School of Chemistry, University College Dublin, Dublin 4, Ireland.
Photosensitized damage by the mechanism of direct 1e transfer from a nucleobase to the metal complex is a complementary approach to type I and type II methods of photodynamic therapy. In this ultrafast spectroscopic study we report the ability of a nitrile infrared redox probe to report on the photo-oxidation of guanine-rich DNA, comprising persistent runs of guanine, by the dppz-10-CN containing complex [Ru(TAP)(dppz-10-CN)] (), dppz-10-CN = 10-cyano-dipyrido[3,2-a:2',3'-c]phenazine and TAP = 1,4,5,8-tetraazaphenanthrene. Our study reveals the ability of the enantiomers of to photo-oxidize guanine in double-stranded and quadruplex DNA.
View Article and Find Full Text PDFJ Phys Chem B
August 2025
Department of Chemistry, University of Isfahan, Isfahan 81746-873441, I. R. Iran.
DNA can be protonated in an acidic microenvironment and therefore may undergo denaturation. Specially, during photodynamic therapy, which usually proceeds via oxidation and nitration of the DNA bases of the cancer cells, protonation may result in DNA structural deformation and consequently accelerate its denaturation and destruction. In the present study, the effect of the protonation of cytosine (at N3), along with the oxidation/nitration of guanine, on the structural instability and possible denaturation of the double-strand dodecamer B-DNA has been investigated using ReaxFF reactive molecular dynamics (RMD) simulations.
View Article and Find Full Text PDFInt J Mol Sci
July 2025
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
The enzyme ABH2, one of nine human DNA dioxygenases of the AlkB family, belongs to the superfamily of Fe(II)/α-ketoglutarate-dependent dioxygenases and plays a crucial role in the direct reversal repair of nonbulky alkyl lesions in DNA nucleobases. ABH2 has broad substrate specificity, directly oxidizing DNA damages such as -methyladenine, -methylcytosine, 1,-ethenoadenine, 3,-ethenocytosine, and a number of others. In our investigation, we sought to uncover the subtleties of the mechanisms governing substrate specificity in ABH2 by focusing on several critical amino acid residues situated in its active site.
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