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Rheumatol Int
September 2025
Division of Perinatology, Department of Obstetrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Istanbul, Turkey.
Familial Mediterranean Fever (FMF) is frequently diagnosed during reproductive ages, but its impact on pregnancy remains unclear. We aimed to evaluate maternal and neonatal outcomes in FMF pregnancies by comparing before and after diagnosis periods as well as with healthy controls, and to identify predictors of adverse outcomes. This retrospective, cross-sectional study included 215 pregnancies (129 before and 86 after FMF diagnosis) from 81 women with FMF and 94 pregnancies from 42 healthy controls.
View Article and Find Full Text PDFEClinicalMedicine
September 2025
Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 201204, China.
Background: Recurrent spontaneous abortion (RSA) poses a significant clinical challenge for childbearing women. Cyclosporine A (CsA), first introduced by our group for RSA treatment, has gained wide clinical application in China, yet remains underutilized internationally. With this systematic review, we aimed to systematically evaluate the efficacy and safety of CsA based therapy in the management of RSA.
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September 2025
Institute of Forensic Science, Department of Pathology, Jiaxing University, Jiaxing, Zhejiang, China.
Pyroptosis, a form of programmed cell death characterized by inflammasome-mediated cellular swelling and membrane perforation. This pathway is involved in diverse pathophysiological processes, including inflammatory diseases and tumors. Notably, the role of pyroptosis in pregnancy-related diseases such as preeclampsia, recurrent spontaneous abortion, neonatal developmental dysplasia, preterm birth, and gestational diabetes mellitus has not been elucidated yet.
View Article and Find Full Text PDFInt J Gen Med
August 2025
College of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Objective: To investigate the therapeutic effects of Bushen Huoxue Formula combined with aerobic exercise (COMB) on reproductive function in obese polycystic ovary syndrome (PCOS) mice.
Methods: Seventy-six 3-week-old female C57BL/6JGpt mice were randomly divided into a control group (CON, =14) and a model group (MOD, =62). The PCOS model was established using a high-fat diet (HFD) combined with dehydroepiandrosterone (DHEA).
AIDS Res Ther
August 2025
Department of Pharmacology, Faculty of Medicine, Lira University, P.O. Box 1035, Lira, Uganda.
Introduction: Abortion is a critical reproductive health issue among young women living with HIV (YWLHIV). Despite the widespread use of the antiretroviral therapy (ART) for women of reproductive age, its impact on abortion prevalence remains unclear. We set out to determine the prevalence of abortion among the YWLHIV receiving TLD-based ART regimen in northern Uganda and its association with the ART regimen and duration alongside other key socio-demographic, reproductive health, lifestyle and facility access- related factors.
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