Modeling Alzheimer's disease in mice: Gonadectomy combined with bilateral hippocampus dentate gyrus injection of Aβ oligomers.

Background: Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for almost half of all dementia cases globally and is progressively increasing. Etiology includes heredity, genetic factors, aging, and nutrition, but sex hormones also play a key role. Reliable animal models of AD are the basis for gaining insight into the pathophysiological mechanisms of AD and for developing and evaluating novel therapeutic strategies for preclinical AD.

Synthesis of a highly conductive coordination polymer film a vapor-solid phase chemical conversion process.

A novel vapor-solid phase chemical conversion process is reported here to synthesise high-quality films of the conductive coordination polymer (c-CP) AgBHT (BHT = benzenehexanothiolate), which has the potential to be applied for the synthesis and processing of c-CP electronic devices. This approach involves reacting a silver oxide precursor and an HBHT linker in an isopropanol solvent vapor atmosphere to obtain AgBHT thin films with controllable thickness (100-300 nm). The as-synthesized AgBHT thin films exhibit conductivities as high as 10 S cm.

2D Conductive Metal-Organic Frameworks Based on Tetraoxa[8]circulenes as Promising Cathode for Aqueous Zinc Ion Batteries.

Aqueous zinc-ion batteries (ZIBs) are the new generation electrochemical energy storage systems. Recently, two-dimensional conductive metal-organic frameworks (2D c-MOFs) are attractive to serve as cathode materials of ZIBs due to their compositional diversity, abundant active sites, and excellent conductivity. Despite the growing interest in 2D c-MOFs, their application prospects are still to be explored.

Nonporous, conducting bimetallic coordination polymers with an advantageous electronic structure for boosted faradaic capacitance.

Conductive coordination polymers (c-CPs) are promising electrode materials for supercapacitors (SCs) owing to their excellent conductivity, designable structures and dense redox sites. However, despite their high intrinsic density and outstanding electrical properties, nonporous c-CPs have largely been overlooked in SCs because of their low specific surface areas and deficient ion-diffusion channels. Herein, we demonstrate that the nonporous c-CPs AgBHT (BHT = benzenehexathiolate) and CuAgBHT are both battery-type capacitor materials with high specific capacitances and a large potential window.

Dual-Emission 2D Blue Luminescent Organic Silver Chalcogenide for Highly Selective Pb Detection in an Aqueous Medium.

Crystalline organic metal chalcogenides (OMCs) are a class of organic-inorganic hybrid semiconducting materials with continuous M-X (X = S, Se, Te) networks formed by the combination of metal nodes and chalcogen atoms from the organic ligands, which display great potentials in the fields of optoelectronics, catalysis, sensing, as well as energy conversion and storage. Here, we synthesized a wave-like 2D OMC material, [(AgBF)MeBHS] (Ag-BHSMe), from AgBF and 1,2,3,4,5,6-hexa(methylselanyl)benzene (MeBHS) through a simple homogeneous reaction. In the solid state, Ag-BHSMe exhibits both fluorescence emission at room temperature and phosphorescent emission at 77 K.