Anthropogenic noise triggers mortality and molecular stress in the copper-blooded marine invertebrate: The horseshoe crab (Tachypleus tridentatus).

The rapid expansion of offshore wind farms to meet clean energy demands has raised concerns about the effects of anthropogenic noise on intertidal benthic organisms. Horseshoe crabs (Tachypleus tridentatus), ancient marine invertebrates with a unique copper-based blue blood system, serve as key indicators of intertidal ecosystem health. Despite their ecological and biomedical significance, the effects of anthropogenic noise on copper-blooded marine species remain poorly understood.

Histopathological and histochemical analysis of the digestive tract of adult horseshoe crabs under mercury stress.

Mercury (Hg) contamination is a major environmental concern that continuously impacts marine organisms, including the mangrove horseshoe crab (Carcinoscorpius rotundicauda). As a vulnerable species, C. rotundicauda holds significant ecological and evolutionary value, making it particularly susceptible to Hg pollution and deserving of focused conservation efforts.

Knockout of rbm24a and rbm24b genes in zebrafish impairs skeletal and cardiac muscle integrity and function during development.

Backgound: Skeletal and cardiac muscles are contractile tissues whose development and function are dependent on genetic programs that must be precisely orchestrated in time and space. In addition to transcription factors, RNA-binding proteins tightly regulate gene expression by controlling the fate of RNA transcripts, thus specific proteins levels within the cell. Rbm24 has been identified as a key player of myogenesis and cardiomyogenesis in several vertebrates, by controlling various aspects of post-transcriptional regulation, including pre-mRNA alternative splicing and mRNA stabilization.

Integrated transcriptomics and metabolomics reveal the toxic mechanisms of mercury exposure to an endangered species Tachypleus tridentatus.

Mercury (Hg) pollution is threatening the health of endangered Tachypleus tridentatus whereas the toxic mechanism is still unclear. This study combined transcriptomic and metabolomics technology to reveal the toxic mechanisms of mercury (Hg , 0.025 mg/L) exposing to T.

A new strategy for optimizing marine protection networks by considering functional connectivity: An example of Tachypleus tridentatus.

The concept of creating a conservation network through the establishment of multiple protected areas to protect marine fauna is gaining momentum. To effectively establish a network that yields favorable outcomes, it is imperative to identify suitable areas that foster optimal connectivity. Given the swift development of coastal areas, it has become necessary to develop cost-effective measures that yield maximum conservation benefits.

Impact assessment of human activities on resources of juvenile horseshoe crabs in Hainan coastal areas, China.

The booming coastal zone economy poses increasing anthropogenic threats to marine life and habitats. Using the endangered living fossil horseshoe crab (HSC) as an example, we quantified the intensity of various anthropogenic pressures along the coast of Hainan Island, China, and for the first time assessed their impact on the distribution of juvenile HSCs through a field survey, remote sensing, spatial geographic modeling, and machine learning methods. The results indicate that the Danzhou Bay needs to be protected as a priority based on species and anthropogenic pressure information.

A novel cadmium detoxification pathway in Tri-spine horseshoe crab (Tachypleus tridentatus): A 430-million-years-ago organism.

Marine and intertidal heavy metal pollution has been a major concern in recent years. Tachypleus tridentatus has existed on earth for more than 430 million years. It has suffered a sharp decline in population numbers caused by environmental pollution and anthropogenic disturbance for almost 40 years.

Impact of Different Diets on Adult Tri-Spine Horseshoe Crab, .

Effective culture and management of adult tri-spine horseshoe crab, can ensure that stock enhancement programs and aquaculture systems are maintained. To explore suitable feed for animals during the breeding season, Pacific oyster () (oyster group; OG) and frozen sharpbelly fish () (frozen fish group; FG) were selected to feed 20 male and female pairs, respectively. At the end of the experiment, intestinal samples were obtained to measure digestive enzymes activities.

Circular RNA hsa_circ_0131242 Promotes Triple-Negative Breast Cancer Progression by Sponging hsa-miR-2682.

Objective: CircRNAs are emerging as vital regulators in a variety of cancers. However, the expression pattern and potential mechanism of circRNAs in triple-negative breast cancer remain unclear. In this study, we aim to systematically investigate circRNAs alteration in triple-negative breast cancer tissues.

Use of trastuzumab as an adjuvant/neoadjuvant therapy in patients with HER2-positive breast cancer in China: The Nvwa study.

The aim of this study was to understand current trends in trastuzumab use in China as a neoadjuvant/adjuvant therapy for human epidermal growth factor receptor-2 positive (HER2+) breast cancer and identify factors influencing trastuzumab use.This was a retrospective, multicenter, cross-sectional study of patients diagnosed with HER2+ breast cancer (stage I-III), between July 2013 and June 2014, at 155 hospitals in 29 provinces/cities in China. Demographic and clinical data, including tumor characteristics and details of adjuvant/neoadjuvant therapies used, were collected.

Influence of Attachment Height and Shape on Lateral Force Transmission in Implant Overdenture Treatment.

Purpose: The purpose of this preliminary study was to examine the influence of overdenture attachment height and shape on lateral force on implants and denture displacement.

Materials And Methods: A straight model was fabricated to simulate the edentulous ridge. Two strain gauges were attached to the mesial and distal surfaces of the implant in the canine area.