Geochronology, geochemistry, and geological significance of early Jurassic intrusive rocks in the Lesser Xing'an- Zhangguangcai Range, northeast China.

The Lesser Xing'an-Zhangguangcai Range of northeast China is located in the eastern segment of the Central Asian Orogenic Belt (CAOB), which records intense magmatism during the Mesozoic. The petrogenesis and geodynamic setting of the Early Jurassic intrusive rocks in this region are unclear. In this paper, we present new zircon U-Pb age and whole-rock geochemical data for these intrusive rocks to investigate their origins and tectonic setting.

Aberrant Splicing of Intronic Variant Contribute to the Pathogenesis of X-Linked Alport Syndrome: A Case Series.

Introduction: X-linked Alport syndrome (XLAS) is caused by pathogenic variants in which lead to abnormalities of the glomerular basement membrane (GBM) structural and is characterized by progressive kidney disease, hearing loss, and ocular abnormalities. The aim of this study was to identify gene mutations in a Chinese family with XLAS by whole-exome sequencing (WES) and verified the pathogenicity of the mutation in vitro experiments.

Case Presentation: A five-generation pedigree with a total of 49 family members originating from Hainan province of China was investigated in this study.

The association of low serum uric acid with mortality in older people is modified by kidney function: National Health and Nutrition Examination Survey (NHANES) 1999-2018.

Background: In older individuals, the role of low serum uric acid (SUA) as risk factor for mortality is debated. We therefore studied whether SUA levels, particularly low SUA concentrations, are associated with all-cause and cardiovascular (CV) mortality in older population, and to clarify potential effect modification of kidney function.

Methods: We identified 14,005 older people in National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018.

Governmental regulation induced pesticide retailers to provide more accurate advice on pesticide use to farmers in China.

Background: In China, pesticide retailers have often been accused of providing inaccurate advice on pesticide use to farmers in a chaotic pesticide market. However, it is unclear whether governmental regulation of sales and advice on pesticide use by pesticide retailers induces them to provide accurate advice.

Results: Using survey data of 242 pesticide retailers in 2016, this study analyzes how pesticide retailers in China provide advice on pesticide use to farmers and examines whether governmental regulation induces pesticide retailers to provide accurate advice.

Quantifying high-resolution spatial variations and local source impacts of urban ultrafine particle concentrations.

To quantify the fine-scale spatial variations and local source impacts of urban ultrafine particle (UFP) concentrations, we conducted 3-6 weeks of continuous measurements of particle number (a proxy for UFP) and other air pollutant (CO, NO, and PM) concentrations at 32 sites in Pittsburgh, Pennsylvania during the winters of 2017 and 2018. Sites were selected to span a range of urban land use attributes, including urban background, near local and arterial roads, traffic intersections, urban street canyon, near-highway, near large industrial source, and restaurant density. The spatial variations in urban particle number concentrations varied by about a factor of three.