Effect of the TIM-3/Gal-9 signaling pathway on macrophage polarization in peri-implantitis.

Introduction: Peri-implantitis (PI) is a common complication of oral implant surgeries. Understanding the role of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) and its ligand galectin-9 (Gal-9) in PI is essential for advancing treatment strategies. This study investigated the effect of the TIM-3/Gal-9 signaling pathway on macrophage polarization in PI.

lncRNA HOTAIR regulates radio-resistance in squamous cell carcinoma of the tongue by Notch signaling.

Objective: To minimize local recurrence of tongue cancer, it is necessary to tackle the issues of radiotherapy resistance and sensitivity in tongue squamous cell carcinoma (TSCCa). This study focuses on understanding how HOX transcript antisense intergenic RNA (HOTAIR) influences resistance to radiotherapy in TSCCa by modulating the Notch signaling pathway.

Methods: The TSCCa cells SCC9 and SCC25 were divided into six experimental groups: (1) 8 Gy irradiation group, (2) 8 Gy with negative control, (3) 8 Gy with silent HOTAIR, (4) 8 Gy with null control, (5) 8 Gy with overexpressing HOTAIR, and (6) 8 Gy with silent HOTAIR and Jagged1.

Global trends in the incidence of cancer attributable to human papillomavirus infection: A population-based study.

Human papillomavirus (HPV) plays a significant role in cancers of the head, neck, and anogenital areas. This study aimed to estimate the burden and trends of HPV-related cancers in 44 selected countries from 1990 to 2017. Data on cancers attributable to HPV infection from 1990 to 2017 were extracted from the Cancer Incidence in Five Continents (CI5) plus database.

Porphyromonas gingivalis promotes oral carcinogenesis through the NDK-ATP-P2X7 signal axis: An in vitro experimental study.

Objective: This study aims to investigate how Porphyromonas gingivalis (P. g) secreted nucleoside diphosphate kinase (NDK) affects the tumor-related biological behaviors of oral squamous cell carcinoma (OSCC) cells through NDK-ATP-P2X7 signal axis.

Design: An in vitro co-culture model that includes human OSCC cell lines (SCC 9 and SCC 25) together with P.

Efficacy of two different treatment modalities for juvenile patients with anterior disk displacement without reduction: an 18-month follow-up study.

This study aimed to investigate the prognosis of adolescent patients with anterior disk displacement without reduction (ADDwoR) who were treated with disk repositioning through suturing or arthrocentesis plus hyaluronic acid (HA) combined with stabilization splint (SS). A total of 96 ADDwoR patients aged ranging from 12 to 18 years, were divided into two groups, including 52 patients in Group A (underwent disk repositioning by suturing) and 44 patients in Group B (underwent arthrocentesis plus HA combined with SS). Condylar height, disk length, maximum mouth opening (MMO), maximal protrusive movement (PM), left/right maximal lateral movement (LLM/RLM) and visual analogue scale (VAS) pain scores were comparatively analyzed between the two groups before and after treatment.

Quantitative MRI texture analysis of the lateral pterygoid muscle in unilateral temporomandibular joint disorders.

Background: This study utilized MRI-based texture analysis to quantify structural alterations in the lateral pterygoid muscle (LPM) among MR images with unilateral anterior disc displacement (uADD) of the temporomandibular joint. Retrospective analysis of anonymized MR images from 232 uADD patients and 123 healthy individuals (January 2022- December 2024), approved by the Ethics Committee of Wenzhou Medical University Affiliated School of Stomatology (Ethics Number: WYKQ 2024008) with waived informed consent due to the use of de-identified retrospective data, was conducted to identify diagnostic markers and possible related pathological changes of disc displacement. According to the inclusion and exclusion criteria four groups of MR images were included in this study: the healthy temporomandibular joints (H-TMJ) of individuals with uADD, joints with anterior disc displacement with reduction (ADDwR), joints with anterior disc displacement without reduction (ADDwoR), and MR images from normal volunteers as the healthy group (HG).

Pan-immune-inflammatory value and systemic immune-inflammatory index in relation to osteoradionecrosis of the jaws: a single institutional experience over 15 years.

Osteoradionecrosis of the jaws (ORNJ) is a pernicious complication of radiation therapy that significantly affects the quality of life of patients with head and neck cancer. The present study aims to investigate the risk factors for the clinical prognosis of ORNJ in the same scenario. A cross-sectional study was designed and implemented in a tertiary teaching hospital from January 2005 to December 2020.

The Impact of miR-141 overexpression on apoptosis and proliferation in Tscca and Tca8113 Cell Lines.

This study investigates the effect of miR-141 overexpression on the proliferation and apoptosis of tongue squamous cell carcinoma (TSCC) cell lines (Tscca and Tca8113). TSCC cells were stably transfected with a miR-141 lentivirus (Ubi-miR-141-SV40-EGFP-IRES-puromycin, miR-141 group) or an empty vector (Ubi-MCS-SV40-EGFP-IRES-puromycin, miR-NC group), with untreated cells serving as the Blank group. miR-141 expression was evaluated by rt-qPCR, transfection efficiency and apoptosis were assessed by flow cytometry, and cell proliferation was measured using the CCK-8 assay.

A novel combination of treatments for acute anterior disc displacement without reduction of temporomandibular joint.

This study aimed to evaluate the effectiveness of a new combined treatment approach using arthrocentesis, hyaluronic acid (HA) injection, mandibular manipulation (MM), and the Twin-Block appliance (TBA) for managing acute anterior disc displacement without reduction (ADDwoR). A retrospective cross-sectional study was designed. Thirty-seven patients (38 joints) diagnosed with acute ADDwoR were treated with arthrocentesis plus HA combined with MM and TBA in turn from January 2022 to December 2023.

Deliberation concerning the role of M1-type macrophage subset in oral carcinogenesis.

Over the last decade, accumulating evidence has suggested that tumor-associated macrophages (TAMs) play a significant role in the tumor development. This commentary wishes to highlight the findings by You, et al. that M1-like TAMs could cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma (OSCC) via the IL6/Stat3/THBS1 feedback loop.

Chondromyxoid fibroma of the temporomandibular joint - a rare case.

Background: Chondromyxoid fibroma (CMF) is a rare cartilaginous tumor, accounting for < 1% of benign bone tumors. We report a case of temporomandibular joint (TMJ)-CMF, involving the pterygopalatine space and skull base and discuss its epidemiology, clinical characteristics, and management.

Case Presentation: A 56-year-old woman presented with facial asymmetry and progressive mouth opening restriction due to a mass expanding upwardly to the auriculotemporal region.

Biomechanism of abnormal stress on promoting osteoarthritis of temporomandibular joint through Piezo1 ion channel.

Objective: This study aimed to investigate whether flow fluid shear stress (FFSS)-mediated signal transduction affects the function of Piezo1 ion channel in chondrocyte and to further explore the role of mechanical overloading in development of temporomandibular joint osteoarthritis (TMJ OA).

Methods: Immunohistochemical staining was used to determine the expression of Piezo1 in TMJ OA tissue collected from rat unilateral anterior crossbite (UAC) models. Chondrocytes harvested from normal adult SD rats were treated with FFSS (0, 4, 8, 12 dyn/cm) in vitro.

A radiobiological perspective on radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma.

Background: This article aimed to compile and summarize clinically relevant literature in radiation therapy, and to discuss the potential in radioresistant and radiosensitive head and neck cancer.

Study Design: Narrative review.

Materials And Methods: Google Scholar, PubMed and the Cochrane Library were retrieved using combined key words such as "radiotherapy" and "head and neck cancer".

Effect of Prophylactic Placement of Percutaneous Endoscopic Gastrostomy on the Surgical Prognosis in Patients With Oral Cancer: A Pilot Study.

This study assessed the application of prophylactic percutaneous endoscopic gastrostomy (pPEG) in patients with newly diagnosed oral cancer (OC) who underwent surgery and were ready for subsequential chemoradiation. In total, 113 patients who underwent OC surgical treatment were divided into pPEG (n = 26), nasogastric tube (n = 54), and oral feeding (n = 33) groups. Their baseline characteristics, surgery-related outcomes, and nutritional data were analyzed using the Wilcoxon rank-sum test and χ2 test.

A PRISMA meta-analysis for diagnostic value of microRNA-21 in head and neck squamous cell carcinoma along with bioinformatics research.

Objectives: The use of miR-21 expression remains vague in diagnosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to systematically evaluate the diagnostic potential of the miR-21 expression in patients with HNSCCs through investigating and summarizing the results reported in the literature.

Methods: Extant medical databases were examined for articles of clinical study assessing the miR-21 expression in HNSCC cases, published in the past 20 years.

Radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma: biological angle.

Objective: This narrative review aimed to compile and summarize clinically relevant literature in radiation therapy and to discuss the potential in radioresistant and radiosensitive head and neck squamous cell carcinoma (HNSCC).

Methods And Materials: Google Scholar, PubMed, and the Cochrane Library were retrieved using combined key words such as "radiotherapy" and "head and neck cancer." Search strings additionally queried were "radioresistant," "radiosensitive," "head and neck region," "squamous cell carcinoma," in combination with Boolean operators 'AND' and 'OR.

Risk assessment of venous thromboembolism in head and neck cancer patients and its establishment of a prediction model.

Importance: Venous thromboembolism (VTE) is closely relevant to head and neck cancer (HNC) prognosis, but little data exist on the risk prediction of VTE in patients with HNC.

Objective: To study the risk factors regarding VTE in HNC patients and construct a nomogram model for its prediction.

Design, Setting, And Participants: A cross-sectional retrospective study was implemented to comparatively analyze 220 HNC patients from January 2018 to December 2021.