Tracking moisture contents in the pollution layer on a composite insulator surface using hyperspectral imaging technology.

Electrical insulators used in transmission lines and outdoor substations are exposed to severe environmental pollution, which significantly increases the risk of power system failure, especially when the pollution layer is highly humid due to adverse weather conditions. The focus of this paper is to establish an effective method for assessing the moisture content (MC) in pollution layers as it serves as a crucial indicator for evaluating the risk of failure in insulators. Hyperspectral imaging (HSI) technology with a spectral range of 371.

The therapeutic prospects of N-acetylgalactosamine-siRNA conjugates.

RNA interference has become increasingly used for genetic therapy following the rapid development of oligonucleotide drugs. Significant progress has been made in its delivery system and implementation in the treatment of target organs. After a brief introduction of RNA interference technology and siRNA, the efficiency and stability of GalNAc-siRNA conjugates are highlighted since several oligonucleotide drugs of GalNAc have been approved for clinical use in recent years.

Testing facility location and dynamic capacity planning for pandemics with demand uncertainty.

The outbreak of coronavirus disease 2019 (COVID-19) has seriously affected the whole world, and epidemic research has attracted increasing amounts of scholarly attention. Critical facilities such as warehouses to store emergency supplies and testing or vaccination sites could help to control the spread of COVID-19. This paper focuses on how to locate the testing facilities to satisfy the varying demand, i.

Insight Into the Prospects for RNAi Therapy of Cancer.

RNA interference (RNAi), also known as gene silencing, is a biological process that prevents gene expression in certain diseases such as cancer. It can be used to improve the accuracy, efficiency, and stability of treatments, particularly genetic therapies. However, challenges such as delivery of oligonucleotide drug to less accessible parts of the body and the high incidence of toxic side effects are encountered.

Regulation of the osteoblastic and chondrocytic differentiation of stem cells by the extracellular matrix and subsequent bone formation modes.

While various factors have been reported to direct stem cell differentiation lineage, little is known about how nature orchestrates the mesenchymal stem cell (MSC) differentiation and bone morphogenesis during skeleton development and bone regeneration. The present study reports that the matrix has a critical regulating effect on MSC differentiation and the subsequent bone formation modes. A simply combined hydroxyapatite (HA)-collagen matrix stimulates the MSC differentiation into the osteoblastic lineage and leads to a straightforward intramembranous bone formation mode, in contrast to the chondrocytic differentiation and endochondral mode observed on HA-synthetic hydrogel matrix.