Myricetin alleviates DNCB-induced atopic dermatitis by modulating macrophage M1/M2 polarization.

Background: Atopic dermatitis (AD), a chronic and relapsing inflammatory skin disease, is characterized by recurrent eczema, itch, and pain. Conventional treatments, such as topical corticosteroids, are associated with various adverse effects. Previous studies have shown that Myricetin (Myr) effectively treats AD and inflammation induced by DNFB and MC903.

Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo.

With the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs.

Cyclometalated iridium(III) complexes combined with fluconazole: antifungal activity against resistant .

() is a ubiquitous clinical fungal pathogen. In recent years, combination therapy, a potential treatment method to overcome resistance, has gained traction. In this study, we synthesized a series of cyclometalated iridium(III) complexes with the formula [Ir(C-N)(tpphz)](PF) (C-N = 2-phenylpyridine (ppy, in ), 2-(2-thienyl)pyridine (thpy, in ), 2-(2,4-difluorophenyl) pyridine (dfppy, in ), tpphz = tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) and polypyridyl ruthenium(II) complexes with the formula [Ru(N-N)(tpphz)](PF) (N-N = 2,2'-bipyridine (bpy, in ), 1,10-phenanthroline (phen, in ), 4,7-diphenyl-1,10-phenanthroline (DIP, in )), and investigated their antifungal activities against drug-resistant and their combination with fluconazole (FLC).

Three new diterpenoids isolated from Hand.-Mazz and their anti-fungal activity.

Three new diterpenoids, named nematocynine A-C (1-3), together with twelve known compounds (4-15) were isolated from the aerial part of Hand.-Mazz (Hereinafter referred to ). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data.

Lactobacillus murinus: A key factor in suppression of enterogenous Candida albicans infections in Compound Agrimony enteritis capsules-treated mice.

Ethnopharmacological Relevance: Compound Agrimony (FuFangXianHeCao, FFXHC) Enteritis Capsules is an ethnomedicine that is derived from Yi Nationality Herbal Medicine for enteritis treatment. We found that FFXHC reduced the mortality outcomes in enterogenic Candida albicans infected mice models and increased the abundance of Lactobacillus murinus in the intestines. Lactobacillus murinus exhibited comparable therapeutic effects to those of FFXHC in enterogenic Candida albicans infected mice.