Identification of small-molecule inhibitors for GluN1/GluN3A NMDA receptors via a multiscale CNN-based prediction model.

N-methyl-D-aspartate receptors (NMDARs) are critical mediators of excitatory neurotransmission and are composed of seven subunits (GluN1, GluN2A-D, and GluN3A-B) that form diverse receptor subtypes. While GluN1/GluN2 subtypes have been extensively characterized and have led to approved therapeutics, the GluN1/GluN3A subtype remains underexplored despite emerging evidence of its involvement in neuropsychiatric disorders. Efficient identification of modulators requires accurate prediction of drug-target affinity (DTA), particularly for challenging targets such as GluN1/GluN3A.

[Kinetics and Reactive Species Analysis of Dimetridazole Degradation by TiO2].

Dimetridazole is considered as an emerging pollutant in waterbodies, which can potentially impact ecosystem and human health. Heterogeneous photocatalytic decomposition of dimetridazole by TiO2 was investigated under 365 nm UV light and effects of initial pH, TiO2 content and dimetridazole concentration on photocatalytic process were discussed. The results indicated that the optimized experiment condition is that the TiO2 content of 1 g x L(-1), dimetridazole concentration of 40 mg x L (-1), pH of 11, dimetridazole can be removed 90%.

[Photocatalytic Degradation of Perfluorooctanoic Acid by Pd-TiO2 Photocatalyst].

Perfluorooctanoic acid (PFOA) is a new persistent organic pollutant which has got global concern for its wide distribution, high bioaccumulation and strong biological toxicity. In present study, the photocatalytic degradation of PFOA using palladium doped TiO2 (Pd-TiO2) prepared by chemical reduction method was investigated. The photocatalysts were characterized by XRD, FESEM and UV-vis DRS and were used for PFOA degradation under 365 nm UV irradiation.

[Photoelectrocatalytic degradation of bisphenol A in water by Fe doped-TiO2 nanotube arrays under simulated solar light irradiation].

Seeking an efficient treatment method for bisphenol A ( BPA), a representative endocrine disrupting compound, is important for environmental remediation and human health. Herein, the degradation of BPA by means of photoelectrocatalysis was investigated. Fe doped-TiO2 nanotube arrays ( Fe/TNA ) served as the photoanode, and a xenon lamp simulated the solar light source.

[Photocatalytic degradation kinetics of perfluorooctanoic acid (PFOA) in TiO2 dispersion and its mechanism].

Decomposition of perfluorooctanoic acid (PFOA) is of prime importance since it is recognized as a persistent organic pollutant and is widespread in the environment. Heterogeneous photocatalytic decomposition of PFOA by TiO2 (P25) was investigated under 254 nm UV light. Experimental conditions including initial pH, TiO2 content and PFOA concentration, were varied to demonstrate their effects on the decomposition of PFOA.