USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF.

Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway. However, the regulation of MRGPRF in melanoma remains unclear.

Bidirectional Mendelian randomization and colocalization analysis of gut microbiota on lipid profile.

The gut microbiota plays a crucial role in human health, but its impact on lipid metabolism remains unclear. Understanding the causal relationship between gut bacteria and lipid profiles is essential for developing strategies to prevent and treat dyslipidemia and cardiovascular diseases. This study aimed to assess this relationship using two-sample Mendelian randomization (MR).

A case of high-grade non-intestinal paranasal sinus adenocarcinoma primary in the maxillary sinus: targeted therapy after postoperative immunocombination with chemotherapy.

Background: High-grade non-intestinal-type sinonasal adenocarcinoma (non-ITAC) is a rare and aggressive form of adenocarcinoma with poor prognosis. The current standard treatment approach involves surgery combined with radiation therapy. However, there is a need for exploring additional treatment modalities to improve patient outcomes.

Cloud Computing Image Recognition System Assists the Construction of the Internet of Things Model of Administrative Management Event Parameters.

In order to successfully apply the Internet of Things and cloud computing to the administrative management of spatial structures and realize the systematization, digitization, and intelligence of administrative management, this article draws on research experience in related fields and considers the data characteristics and computing tasks of administrative management. The whole cycle of transmission, storage, postprocessing, and visualization is the main line of research, and a cloud computing-based spatial structure administrative management IoT system is constructed. First, by summarizing the application status of the Internet of Things, the general Internet of Things system is summarized into three levels, and combined with the specific work in the spatial structure administrative management, the overall framework of the spatial structure administrative management of the Internet of Things system is proposed, and the functional sublayers are carried out.

Guideline conformity to the Stupp regimen in patients with newly diagnosed glioblastoma multiforme in China.

To determine how consistently Chinese glioblastoma multiforme (GBM) patients were treated according to the Stupp regimen. The proportion of treatments conforming to the Stupp regimen and reasons for nonconformity were evaluated in 202 newly diagnosed GBM patients. Only 15.

An efficient and non-enzymatic method for isolation and culture of endothelial cells from the nidus of human cerebral arteriovenous malformations.

In this report, we describe an efficient and non-enzymatic method for isolating and culturing endothelial cells (ECs) from the nidus of surgically resected arteriovenous malformation (AVM) specimens. These cultured cells possessed typical phenotypic markers (i.e.

The protective mechanism for the blood-brain barrier induced by aminoguanidine in surgical brain injury in rats.

This study was performed to investigate the mechanism of blood-brain barrier (BBB) permeability change, which was induced by aminoguanidine (AG) after surgical brain injury (SBI) in rats. Compared to control group, AG (150 mg/kg, i.p.

Role of aminoguanidine in brain protection in surgical brain injury in rat.

The study investigated the effect of aminoguanidine (AG) on surgical brain injury (SBI) in rat. AG (75, 150 and 300 mg/kg, i.p.

Holistic and network analysis of meningioma pathogenesis and malignancy.

Meningiomas, which originate from arachnoid cells and constitute the largest subgroup of all intracranial tumors, are generally benign, yet have the capacity to progress into a higher histological grade of malignancy associated with an increase in biological aggressivity and/or capacity to recur. To elucidate meningioma pathogenesis and malignancy, we applied a holistic and network approach analyzing cDNA and tissue microarray results. A potential pathway leading to meningioma angiogenesis, apoptosis and proliferation was evidenced as well as a regulatory network of the biomarkers including Ki-67, AR, CD34, P53, c-MYC, etc.