The Critical Role of Piezo1/CaMKII/β-Catenin Axis in Promoting Osteogenic Differentiation of ADSCs by Pressure Stimulation.

The motor system organs respond to mechanical stimuli, and compressive stimulation promotes osteogenesis by enhancing the differentiation and mineralization of mesenchymal stem cells (MSCs) both in laboratory settings and in living organisms. Piezo1, a crucial ion channel, enables cells to detect external mechanical stimuli and mediates various signaling pathways that regulate osteogenesis. However, the function of Piezo1 in the osteogenic differentiation of MSCs triggered by compressive stimulation is still not well understood.

Associations of Low-Carbohydrate and Low-Fat Diets With Mortality Among Individuals With Hypertension: A Prospective Cohort Study.

Objective: Low-carbohydrate diets (LCDs) and low-fat diets (LFDs) have shown short-term metabolic improvements. However, the associations of different types of LCDs and LFDs with mortality among individuals with hypertension remain unclear when considering the quality of macronutrients and food sources.

Method: The prospective cohort study included 16,379 adults (≥20 years) with hypertension from the National Health and Nutrition Examination Survey from 1999 to 2016 in the United States.

Human dental follicle cell-derived conditioned media enhance periodontal regeneration by regulating the osteogenic differentiation and inflammation of periodontal ligament stem cells and macrophage polarization.

Dental follicle cells (DFCs) derived from the neural crest are promising seed cells for periodontal tissue engineering. This study aimed to investigate whether conditioned media (CM) from human DFCs could regenerate impaired periodontal tissue and the underlying mechanisms. hDFC-derived CM (hDFC-CM) were obtained via ultracentrifugation.

A chromatic feature detector in the retina signals visual context changes.

The retina transforms patterns of light into visual feature representations supporting behaviour. These representations are distributed across various types of retinal ganglion cells (RGCs), whose spatial and temporal tuning properties have been studied extensively in many model organisms, including the mouse. However, it has been difficult to link the potentially nonlinear retinal transformations of natural visual inputs to specific ethological purposes.

Three-dimensional finite element analysis of the biomechanical properties of different material implants for replacing missing teeth.

The purpose of this study was to analyze the biomechanical properties of implants made of different materials to replace missing teeth by using three-dimensional finite element analysis and provide a theoretic basis for clinical application. CBCT data was imported into the Mimics and 3-Matic to construct the three-dimensional finite element model of a missing tooth restored by an implant. Then, the model was imported into the Marc Mentat.

polymorphisms and hepatoblastoma susceptibility in Chinese children.

Hepatoblastoma (HB) is the most prevalent primary hepatic cancer in children aged 6 months to 3 years. is recurrently mutated in various diseases, and critically involved in tumorigenesis. However, a limited number of studies have examined the involvement of polymorphisms in HB risk.

gene polymorphisms modify hepatoblastoma susceptibility in Chinese children.

Hepatoblastoma is one of the malignant liver tumors in children. However, genetic mechanisms underpinning the initiation of hepatoblastoma remain largely unclear. The previous study showed that lin-28 homolog B (LIN28B) might play a role in the development of hepatoblastoma.