The Relationship Between the Experience of Rescue Activities in the 2024 Noto Peninsula Earthquake and Posttraumatic Stress Symptoms and Psychological Distress Among Medical Rescue Workers.

Objective: This study aimed to investigate the association between the experience of rescue activities in the 2024 Noto Peninsula earthquake and posttraumatic stress symptoms (PTSS) and psychological distress among medical rescue workers (MRWs).

Methods: MRWs were recruited from March 8 to March 31, 2024. Outcomes were psychological distress and PTSS.

Characteristics of home-visit nursing stations and psychiatric home-visit nursing service users requiring frequent visits and support coordination in Japan.

This study examined the characteristics of service users requiring frequent visits (≥ 3 times/week) and support coordination from home-visit nursing stations and psychiatric home-visit nursing in Japan. Psychiatric home-visit nursing is vital for individuals with mental disorders, but its implementation has lagged behind physical home-visit nursing because of Japan's historical emphasis on institutional psychiatric care. A questionnaire survey was conducted from October 2024 to January 2025, involving 56 home-visit nursing stations with 224 service users.

Predictive effects of the lactate/albumin ratio on neurological outcomes in patients after out-of-hospital cardiac arrest.

Background: Predicting outcomes for out-of-hospital cardiac arrest (OHCA) patients remains challenging. We aimed to evaluate the association between the lactate/albumin ratio (LAR) upon hospital arrival and neurological outcomes in OHCA patients.

Methods: This multicenter, retrospective, nationwide observational study was based on data from the JAAM-OHCA registry, including 28,098 adults with non-traumatic OHCA from 140 emergency medical centers across Japan (June 2014 to December 2021).

The content of Recovery College courses in England: a 71 college document analysis.

Introduction: Recovery Colleges (RCs) exist in 28 countries and across five continents. The concept of recovery and recovery-oriented care has become widespread internationally and embedded in policy documentation and mental health services. As a result, Recovery Colleges, which focus on adult learning and co-production, have now developed a global presence, but many psychiatrists are unfamiliar with this intervention.

Cultural influences on fidelity components in recovery colleges: a study across 28 countries and territories.

Background: Recovery colleges (RCs) support personal recovery through education, skill development and social support for people with mental health problems, carers and staff. Guided by co-production and adult learning principles, RCs represent a recent mental health innovation. Since the first RC opened in England in 2009, RCs have expanded to 28 countries and territories.

Clinical features and treatments of VEXAS syndrome in critical care: a scoping review.

Background: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a recently discovered severe disorder that predominantly affects adult males, characterized by systemic inflammation and hematologic abnormalities. Despite its profound impact on patient outcomes, awareness of VEXAS syndrome among critical care providers remains severely limited, often leading to delayed recognition, diagnosis, and initiation of appropriate treatment. This study aims to address this knowledge gap by conducting a scoping review on VEXAS syndrome in the critical care setting.

Associations among age at menopause, depressive symptoms, and cognitive function.

Introduction: Evidence is scarce regarding the role of menopause in age-related cognitive function trajectories associated with increased depressive symptoms. We examined the longitudinal association among sex and age at menopause, depressive symptoms, and 2-year follow-up cognitive function.

Methods: We used data from the English Longitudinal Study of Ageing, classifying age at menopause into three categories: < 40, 40 to 49, and ≥ 50 years.

Claudin-11, a hypomyelinating leukodystrophy 22 (HLD22)-responsible protein, uniquely interacts with shroom-2 to change cell phenotypes.

Oligodendroglial cells are a type of glial cell in the central nervous system (CNS) that wrap neuronal axons with differentiated plasma membranes known as myelin sheaths. While the physiological functions of oligodendrocytes, such as generating saltatory conduction and protecting neuronal axons, are well understood, the physiological and/or pathophysiological molecular mechanisms governing their differentiation before myelination remain unclear. In this study, we describe for the first time that claudin-11, a protein associated with hypomyelinating leukodystrophy 22 (HLD22), interacts with shroom-2, a presumable adaptor protein containing the PSD95, DLG1, and ZO-1 (PDZ) domain.

A tardive dyskinesia drug target VMAT-2 participates in neuronal process elongation.

Tardive dyskinesia involves involuntary movements of body parts and is often observed in individuals taking antipsychotics for extended periods. Initial treatment strategies include reducing medication dosage, switching medications, or using drugs to suppress symptoms. One of the therapeutic targets for tardive dyskinesia is vesicular monoamine transporter-2 (VMAT-2, also known as solute carrier family 18 member A2 [SLC18A2]), which functions as an energy-dependent transporter of monoamines.

Characteristics and Outcomes of Veno-Arterial Extracorporeal Membrane Oxygenation in Accidental Hypothermia: A Multicenter Study in Japan.

Despite growing evidence supporting the efficacy of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for accidental hypothermia (AH), few studies have assessed its real-world application. We aimed to describe the use and outcomes of VA-ECMO in AH patients using data from a multicenter registry. This retrospective study included adult AH patients from the Japanese accidental hypothermia network registry (J-Point registry) between April 2011 and March 2016.

Exploring Nuclear Spin Conservation in the CH + H Reaction.

Nuclear spin angular momentum in molecules with identical nuclei is conserved in many physical and chemical processes, but its role in chemical reactions involving atomic rearrangements remains underexplored. In this study, we investigate the nuclear spin selection rules in the reaction between methylene (CH) and hydrogen (H) using high-resolution infrared spectroscopy in quantum solid parahydrogen. Our results show that in the triplet methylene (CH) reaction, the nuclear spin distribution of the products matches perfectly with the expected nuclear spin selection rules for the stepwise reaction mechanism.

Hypomyelinating Leukodystrophy 14 (HLD14)-Related UFC1 p.Arg23Gln Decreases Cell Morphogenesis: A Phenotype Reversable with Hesperetin.

Introduction: In the central nervous system (CNS), proper interaction between neuronal and glial cells is crucial for the development of mature nervous tissue. Hypomyelinating leukodystrophies (HLDs) are a group of genetic CNS disorders characterized by hypomyelination and/or demyelination. In these conditions, genetic mutations disrupt the biological functions of oligodendroglial cells, which are responsible for wrapping neuronal axons with myelin sheaths.

Benefit Finding and Growth Among Family Caregivers of Individuals With Mental Illness: A Scoping Review.

Benefit finding is a concept that represents finding positive changes or benefits through difficult experiences. To map the currently available studies on benefit finding and growth among family caregivers of individuals with mental illness, we conducted a scoping review based on methodological frameworks. A systematic search for studies published in English was conducted using MEDLINE, PsycINFO, PsycARTICLES, CINAHL, and PTSDpubs from inception to August 2023.

Effect of video-based trauma-informed care training for psychiatric nurses: A nonrandomized controlled trial.

Aim: To examine the effect of short-time video-based trauma-informed care (TIC) training in improving attitudes related to TIC and mental health among psychiatric nurses.

Methods: A nonrandomized controlled trial was conducted to investigate the effectiveness of a 60-min TIC training video. The primary outcome measure was the Attitudes Related to Trauma-Informed Care Scale 35 (ARTIC-35).

Reliability and Validity of the Japanese Version of the Internet Gaming Disorder Scale for Children (IGDS-C).

Aim: The Internet Gaming Disorder Scale is a 9-item screening instrument developed based on the diagnostic criteria for Internet Gaming Disorder (IGD) in the DSM-5. This study aimed to examine the reliability and validity of the Internet Gaming Disorder Scale for children (IGDS-C) in Japanese clinical and nonclinical populations.

Methods: The study included clinical outpatients aged 9-29 with problematic game use and nonclinical adolescents aged 12-18 who played online games at least once a week.

Bcl2l12, a novel protein interacting with Arf6, triggers Schwann cell differentiation programme.

Schwann cells are glial cells in the peripheral nervous system (PNS); they wrap neuronal axons with their differentiated plasma membranes called myelin sheaths. Although the physiological functions, such as generating saltatory conduction, have been well studied in the PNS, the molecular mechanisms by which Schwann cells undergo their differentiation programme without apparent morphological changes before dynamic myelin sheath formation remain unclear. Here, for the first time, we report that Arf6, a small GTP/GDP-binding protein controlling morphological differentiation, and the guanine-nucleotide exchange factors cytohesin proteins are involved in the regulation of Schwann cell differentiation marker expression in primary Schwann cells.

Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells.

Small GTP-binding proteins of the Rab family regulate intracellular vesicle trafficking across many aspects of the transport system. Among these, Rab9 is recognized for its role in controlling the transport system not only around the trans-Golgi network but also around the late endosome. However, the specific functions across different cell types and tissues remain unclear.

CRISPR/CasRx-Mediated Knockdown of Rab7B Restores Incomplete Cell Shape Induced by Pelizaeus-Merzbacher Disease-Associated PLP1 p.Ala243Val.

Pelizaeus-Merzbacher disease (PMD, currently known as hypomyelinating leukodystrophy type 1 [HLD1]) is a hereditary hypomyelinating and/or demyelinating disease associated with the proteolipid protein 1 (plp1) gene in the central nervous system (CNS). One of the major causes of this condition is incomplete or defective oligodendroglial cell myelin sheath formation triggered by endoplasmic reticulum (ER) stress and subsequent unfolded protein response (UPR). The HLD1-associated Ala-243-to-Val mutation (p.

Association of depressive symptoms with incidence and mortality rates of COVID-19 over 2 years among healthcare workers in 20 countries: multi-country serial cross-sectional study.

Background: Long-term deterioration in the mental health of healthcare workers (HCWs) has been reported during and after the COVID-19 pandemic. Determining the impact of COVID-19 incidence and mortality rates on the mental health of HCWs is essential to prepare for potential new pandemics. This study aimed to investigate the association of COVID-19 incidence and mortality rates with depressive symptoms over 2 years among HCWs in 20 countries during and after the COVID-19 pandemic.

Hypomyelination Leukodystrophy 16 (HLD16)-Associated Mutation p.Asp252Asn of TMEM106B Blunts Cell Morphological Differentiation.

Transmembrane protein 106B (TMEM106B), which is a type II transmembrane protein, is believed to be involved in intracellular dynamics and morphogenesis in the lysosome. TMEM106B is known to be a risk factor for frontotemporal lobar degeneration and has been recently identified as the receptor needed for the entry of SARS-CoV-2, independently of angiotensin-converting enzyme 2 (ACE2). A missense mutation, p.

Myelination by signaling through Arf guanine nucleotide exchange factor.

During myelination, large quantities of proteins are synthesized and transported from the endoplasmic reticulum (ER)-trans-Golgi network (TGN) to their appropriate locations within the intracellular region and/or plasma membrane. It is widely believed that oligodendrocytes uptake neuronal signals from neurons to regulate the endocytosis- and exocytosis-mediated intracellular trafficking of major myelin proteins such as myelin-associated glycoprotein (MAG) and proteolipid protein 1 (PLP1). The small GTPases of the adenosine diphosphate (ADP) ribosylation factor (Arf) family constitute a large group of signal transduction molecules that act as regulators for intracellular signaling, vesicle sorting, or membrane trafficking in cells.