A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer.

One of the major goals of precision oncology is to promote combination therapy to improve efficacy and reduce side effects of anti-cancer drugs based on their molecular mechanisms. In this study, we aimed to develop and validate new nanoformulations of docetaxel (DTX) and bortezomib (BTZ) for targeted combination therapy to treat human esophageal cancer. By leveraging our versatile disulfide cross-linked micelles (DCMs) platform, we developed nanoformulations of DTX and BTZ (named DTX-DCMs and BTZ-DCMs).

Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer.

Histone deacetylase (HDAC) inhibitors are an emerging class of targeted therapy against cancers. Thailandepsin A (TDP-A) is a recently discovered class I HDAC inhibitor with broad anti-proliferative activities. In the present study, we aimed to investigate the potential of TDP-A in the treatment of breast cancer.

Spatial-temporal variations of Schistosoma japonicum distribution after an integrated national control strategy: a cohort in a marshland area of China.

Background: Schistosomiasis transmission is typically focal. Understanding spatial variations of Schistosoma infections and their associated factors is important to help to invent site-specific intervention strategies.

Methods: A five-year longitudinal study was carried out prospectively in 12 natural villages, Guichi district of Anhui province.

Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer.

Aim: This work aimed to determine if the treatment outcomes of bladder cancer could be improved by targeting micelles that are decorated with bladder cancer-specific ligands on the surface and loaded with the chemotherapeutic drug paclitaxel.

Materials & Methods: Targeting efficacy and specificity was determined with cell lines. An in vivo targeting and anti-tumor efficacy study was conducted in mice carrying patient-derived xenografts.

[Application of saTScan in detection of schistosomiasis clusters in marshland and lake areas].

Objective: To detect the schistosomiasis clusters in marshland and lake areas in 2008, so as to provide the reference for schistosomiasis control and the methodology for detection of cluster areas of related diseases.

Methods: SaTScan was used to detect the schistosomiasis clusters based on the spatial database from GIS and related variables, including the number of current patients and population in endemic areas.

Results: A total of 5 clusters including 39 counties (districts) were detected by SaTScan, the RRs and the Log-likelihood ratios of 3 clusters among them were over 3 and 1 000 (P < 0.

[Snail habitats detection in the marshland of Eastern Dongting Lake Area, based on China-Brazil Earth Resources Satellite-02B CCD data].

Objective: To detect the snail habitats from the marshland of Eastern Dongting Lake Area, using the Remote Sensing (RS) and Geographic Information System (GIS) technology based on the China-Brazil Earth Resources Satellite-02B (CBERS-02B) CCD images.

Methods: According to the two typical traits of snail habitats in marshland including "water in summer and land in winter" and "no grass, no snails", the "water in summer and land in winter" region and the vegetation coverage region were calculated by RS image processing respectively. The two regions mentioned above were then overlapped to confirm the snail habitats through comparing with the data from field survey under spatial overlapping of Arcgis as the last step.

[Spatial characteristic of distribution of Oncomelania hupensis in mountainous regions].

Objective: To analyze the spatial characteristic on the distribution of Oncomelania hupensis in mountainous regions.

Methods: Based on the geographic database of snail distribution in Puge county, Sichuan province, spatial autocorrelation analysis and spatial scan statistics were applied to analyze the spatial characteristic of snail distribution.

Results: With regard to the rate of frame with snails, the global Moran's I indicator was 0.

[Influence regarding micro-ecological environment of snail habitats in lake area on the distribution of snails].

Objective: To explore the relationships between micro-ecological environmental factors and the density of Snails so as to provide information for the elimination of Snails and control of Schistosomiasis disease, under ecological methods.

Methods: A bottomland close to Junshan Park in Yueyang city, Hunan province was selected as the field for survey during 10, 2007 - 10, 2008, and a systematic sampling method was applied to determine the specific sites of Snail investigation. All the Snails in each frames were collected and the soil surface temperature and vegetation coverage in several frames were measured.

[Integrated detection and analysis on the clusters of schistosomiasis based on geographic information system].

Objective: To detect and analyze the clusters of schistosomiasis on marshland and lake areas based on geographic information system (GIS) in 2008 and to provide suggestions for the development of integrated methodology on the detection of clusters on related diseases.

Methods: Moran's I of global spatial autocorrelation, Getis-Ord Gi of local spatial autocorrelation and SaTScan were used to detect the schistosomiasis clusters based on GIS and comparison of the results for different methods were performed.

Results: Results from the global Moran's I tests for all the marshland and lake areas related to the schistosomiasis were statistically significant (P < 0.

[Metagenesis of intermediate host to Schistosoma japonicum Oncomelania snail in mountainous areas].

Objective: To understand the metagenesis of Oncomelania snails in the mountainous regions so as to control the spread of snails and the epidemics of schistosomiasis.

Methods: Observation spot was established at a typical snail habitat close to Puge county, Sichuan province from February 2008 to July 2009. Random sampling was applied to determine the place of each frame during the observation.

[Impact of the changing water level on the variance of Oncomelania hupensis populations in Lake Area with general additive model].

Objective: To explore the impact and regularity of snail population after changing of water level and to develop effective control and prediction programs.

Methods: A typical snail habitat closed to Changjiang county in Yueyang city, Hunan province was selected as the survey field. Data on water level and the changing trend of snail population during 2001 - 2009 including the average water level, maximum and minimum water levels, snail and infected snail densities, proportion of sampling frames with living and infected snails etc.