5-methylcytosine methylation of MALAT1 promotes resistance to sorafenib in hepatocellular carcinoma through ELAVL1/SLC7A11-mediated ferroptosis.

Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) play a crucial role in sorafenib resistance in hepatocellular carcinoma (HCC), and lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a dysregulated lncRNA in sorafenib-resistant HCC cells. However, the underlying regulatory mechanisms of MALAT1 in sorafenib-resistant HCC cells remain unclear. In the present study, we demonstrated that 5-methylcytosine (mC) methylation catalyzed by NSUN2 and ALYREF contributed to the RNA stability and upregulation of MALAT1.

Phonon Directionality Impacts Electron-Phonon Coupling and Polarization of the Band-Edge Emission in Two-Dimensional Metal Halide Perovskites.

Two-dimensional metal halide perovskites are highly versatile for light-driven applications due to their exceptional variety in material composition, which can be exploited for the tunability of mechanical and optoelectronic properties. The band-edge emission is defined by the structure and composition of both organic and inorganic layers, and electron-phonon coupling plays a crucial role in the recombination dynamics. However, the nature of the electron-phonon coupling and what kind of phonons are involved are still under debate.

Limitations and Innovative Application Methods of Surfactants for Solubilization of Poorly Water-Soluble Drugs.

Poor solubility of drugs leads to poor bioavailability and therapeutic efficiency. A large proportion of drugs that are not developed and marketed for use by patients are due to their extremely low solubility. Therefore, improving the solubility of poorly water-soluble drugs is one of the most important aspects of the field of drug research.

EIF4A3-negatively driven circular RNA β-catenin (circβ-catenin) promotes colorectal cancer progression via miR-197-3p/CTNND1 regulatory axis.

Background: Circβ-catenin, our first reported circRNA, has been reported to mediate tumorigenesis in various cancers. However, its biological functions and underlying mechanisms in colorectal cancer (CRC) remain unknown.

Methods: The qRT-PCR examination was used to detect the expression of circβ-catenin, miR-197-3p, and CTNND1 in cells and human tissues.

Surgical Technique and Efficacy Analysis of Extra-pseudocapsular Transnasal Transsphenoidal Surgery for Pituitary Microprolactinoma.

Objective: To elucidate the role of transsphenoidal surgery in the treatment of pituitary microprolactinoma.

Methods: The clinical data of 107 prolactinoma cases treated by extra-pseudocapsular transnasal transsphenoidal surgery (ETTS) for different indications in our department since 2011 was retrospectively analyzed.

Results: The most common indication was the ineffectiveness of oral medication (41.

[Relationship between natural extinction of snails and water chemical properties in Eastern Dongting Lake areas].

Objective: To investigate the reasons of natural extinction of snails by comparing the difference of the water chemical properties between the snail-breeding marshland and non-snail marshland in Eastern Dongting Lake areas.

Methods: Three adjoining marshlands in Eastern Dongting Lake areas were selected, one was a snail-breeding marshland, the second was a non-snail marshland, and the third was a boundary zone between them. During the periods of water-rising season, wet season and water-falling season, the water samples from the bottom of 0.

[Research on living status of in autumn and winter and its correlates in Eastern Dongting Lake area].

Objective: To explore the dynamic changes of snail densities in autumn and winter and the relationship between hydrological and meteorological factors and snail growth and decline.

Methods: From Octobers to Decembers of 2007 to 2014, a bottomland close to eastern Dongting Lake was selected as the study field. The snails and elevation of the points were surveyed, and the hydrological and meteorological data were collected.

[Effect of comprehensive schistosomiasis control strategy with focus on cattle and sheep removal in Junshan District, Yueyang City].

To evaluate the effect of comprehensive schistosomiasis control measures with focus on total removal of cattle and sheep in Junshan District, Yueyang City. The retrospective review and field survey were implemented in the pilot villages in Junshan District. The data of infection status of human, cattle, sheep and snails, and density of snails were gathered and modeled in the period of 2006 to 2016.

[Temporal and spatial distribution of infection of population and its risk factors in Eastern Dongting Lake area in 2012 and 2014].

Objective: To investigate the temporal and spatial distribution of infection of population and its risk factors in Eastern Dongting Lake area in 2012 and 2014, so as to provide the reference for formulating effective intervention measures.

Methods: Junshan District was selected as a study field in Eastern Dongting Lake area. The method of spatial autocorrelation analysis was applied to analyze the change of spatial distribution of infection in Junshan District in 2012 and 2014.

Three Gorges Dam: Impact of Water Level Changes on the Density of Schistosome-Transmitting Snail Oncomelania hupensis in Dongting Lake Area, China.

Background: Schistosomiasis remains an important public health issue in China and worldwide. Oncomelania hupensis is the unique intermediate host of schistosoma japonicum, and its change influences the distribution of S. japonica.

[Hemocyte morphology and classification in Oncomelania hupensis].

Hemocytes were collected from Oncomelania hupensis in Junshan, Hunan Province and Puge, Sichuan Province, respectively, and stained with Giemsa solution for light microscopic examination. The cells were classified morphologically. Five types of hemocytes were identified, viz.

[Contrastive analysis of environmental factors between Oncomelania hupensis snail marshland and snail natural death marshland in eastern Dongting Lake schistosomiasis endemic areas].

Objective: To study the reasons of natural death of Oncomelania hupensis snails in marshland by comparing the differences of environmental factors between snail marshland and non-snail marshland in East Dongting Lake schistosomiasis endemic areas.

Methods: Two adjoining marshlands were selected, one was a snail marshland and another was a non-snail marshland. The measuring points were set by grid of "20 m x 20 m".

Identification of optimum scopes of environmental factors for snails using spatial analysis techniques in Dongting Lake Region, China.

Background: Owing to the harmfulness and seriousness of Schistosomiasis japonica in China, the control and prevention of S. japonica transmission are imperative. As the unique intermediate host of this disease, Oncomelania hupensis plays an important role in the transmission.

[Distribution of univalvia molluscs in area with natural decline of Oncomelania hupensis snails in Eastern Dongting Lake area].

Objective: To understand the distribution of univalvia molluscs in Eastern Dongting lake area where the Oncomelania hupensis is extinct, so as to explore the causes of extinction and to provide the evidence for formulating schistosomiasis control strategy.

Methods: The univalvia molluscs of the Qianliang Lake district, Jianxin District and Junshan Park were investigated in August of 2013. All the collected snails were classified and identified.

[Short-term effect of black film covering on Oncomelania hupensis snail control in marshland and lake regions].

Objective: To evaluate the short-term effect of the black film covering combined with niclosamide on Oncomelania hupensis snail control in marshland and lake regions.

Methods: A ditch with snails in Anxiang County was selected as the experimental sites. The ditch was divided into 3 groups: a film group, a niclosamide group, and a niclosamide and film group.

[Snail habitats detection in the marshland of Eastern Dongting Lake Area, based on China-Brazil Earth Resources Satellite-02B CCD data].

Objective: To detect the snail habitats from the marshland of Eastern Dongting Lake Area, using the Remote Sensing (RS) and Geographic Information System (GIS) technology based on the China-Brazil Earth Resources Satellite-02B (CBERS-02B) CCD images.

Methods: According to the two typical traits of snail habitats in marshland including "water in summer and land in winter" and "no grass, no snails", the "water in summer and land in winter" region and the vegetation coverage region were calculated by RS image processing respectively. The two regions mentioned above were then overlapped to confirm the snail habitats through comparing with the data from field survey under spatial overlapping of Arcgis as the last step.