Agreement Between Different Types of Blood Pressure Monitoring : A Systematic Review and Network Meta-analysis.

Background: Accurate blood pressure measurement (BPM) is essential for managing hypertension, but previous studies have not systematically compared different monitoring methods across varying BP levels. To address this gap, a comprehensive analysis using network meta-analysis (NMA) and meta-regression was done to evaluate their agreement and clinical implications.

Purpose: To compare BP values obtained using different BPM methods using office BPM (OBPM) as the reference.

Explainable machine learning for predicting aspiration pneumonia after radiotherapy in oral cavity cancer.

Background And Purpose: Aspiration pneumonia is a severe late event that occurs following radiotherapy for oral cavity cancer (OCC). This study aimed to develop explainable machine learning models to predict aspiration pneumonia.

Materials And Methods: This study included 880 patients with OCC (derivation cohort, 561 patients; external validation cohort, 319 patients) who underwent surgery and adjuvant radiotherapy between 2010 and 2020.

Ciprofloxacin Exerts Anti-Tumor Effects In Vivo Through cGAS-STING Activation and Modulates Tumor Microenvironment.

Immunotherapy targeting the immune functions of the tumor microenvironment (TME) is beneficial for colorectal cancer; however, the response rate is poor. Ciprofloxacin is a fluoroquinolone-class antibiotic that is used to treat bacterial infections. The purpose of this study is to assess the mechanism of ciprofloxacin that enhances anti-PD1 in colorectal cancer.

Simultaneous concurrent chemoradiotherapy and esophagectomy for synchronous head and neck and esophageal squamous cell carcinoma: a retrospective review.

Background: This study aimed to assess the clinical outcomes and prognostic factors of patients with synchronous head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC) who underwent simultaneous concurrent chemoradiotherapy (CCRT) and esophagectomy.

Methods: Thirty-one patients who underwent simultaneous CCRT for synchronous HNSCC and ESCC were retrospectively reviewed. The treatment strategy involved simultaneous definitive CCRT at 70 Gy/35 fractions for HNSCC and neoadjuvant CCRT at 48 Gy/24 fractions for ESCC.

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortex.

Down syndrome is the most common genetic cause of intellectual disability, presenting with cognitive, learning, memory, and language deficits. The cellular and molecular mechanisms driving this disorder remain unclear, limited by a lack of systematic studies in the developing human brain. Here, we leveraged single-nucleus multi-omics to profile the mid-gestation neocortex in a cohort of 26 donors.

Correction: Wu et al. Synthesis of Novel Lipophilic -Substituted Norcantharimide Derivatives and Evaluation of Their Anticancer Activities. 2014, , 6911-6928.

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Androgen Deprivation Therapy-Induced Muscle Loss and Fat Gain Predict Cardiovascular Events in Prostate Cancer Patients.

Background: Androgen deprivation therapy (ADT) increases the risk of adverse cardiovascular events in patients with prostate cancer. ADT can induce body composition change; however, the association between body composition change and cardiovascular outcomes remains unclear. This study aimed to determine the association between ADT-induced body composition change and cardiovascular outcomes in patients with prostate cancer.

Primary Prophylaxis for High-Risk Varices in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombus Delayed Hepatic Decompensation: A Retrospective, Propensity Score Matching Study.

Background And Aims: The prevalence of clinically significant portal hypertension (CSPH) is high in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT). There was no evidence of whether primary prophylaxis is beneficial in reducing hepatic decompensation in these patients.

Methods: Clinical records of 445 patients with pathology or radiology-confirmed HCC and PVTT from January 2013 to December 2022 were reviewed, 142 patients having concurrent high-risk varices (HRV) without hepatic decompensation were enrolled.

Agonist-Triggered Ca2+ Release From Functionally Connected Endoplasmic Reticulum and Lysosomal Ca2+ Stores in bEND.3 Endothelial Cells.

Endoplasmic reticulum (ER) and lysosomes are physiologically active, physically and functionally connected intracellular Ca2+ stores. In this study we investigated agonist-triggered Ca2+ release from these two stores in mouse microvascular endothelial bEND.3 cells.

Turns-amplitude and power spectral analyses of surface EMG for assessing muscle fatigue and recovery during dynamic hand gripping.

Monitoring muscle fatigue and recovery is important during exercise. Alterations in the frequency structure of the myoelectric signals have been used to indicate muscle fatigue. The turns-amplitude analysis (TAA) reflects a muscle's summation and cancellation of action potentials.

Omission of multimodal therapy in older adults with high-risk breast cancer.

Purpose: Treatment guidelines recommend multimodal therapy for non-metastatic high-risk breast cancer in older adults. However, older patients may be less likely to receive this due to varying abilities to withstand intensive therapy. We aimed to quantify the incidence of, factors associated with, and reasons behind omission of multimodal therapy in older high-risk breast cancer patients.

Aspirin reverses the inhibitory effect of soluble fms-like tyrosine kinase-1 on trophoblast invasiveness and ciliogenesis through Sonic hedgehog signaling in preeclampsia.

Soluble Flt-1 (sFlt-1) is upregulated in preeclamptic patients and is a predictive biomarker for preeclampsia risk and progression. Aspirin is an effective agent used to prevent preeclampsia and has been shown to suppress sFlt-1 production in trophoblasts; however, the underlying mechanism is not fully understood. Here, we demonstrated that sFlt-1 production was upregulated under hypoxia in two trophoblastic cells (HTR-8/SVneo and JAR).

Pathophysiology and blood pressure measurements of hypertension in the elderly.

Hypertension is a serious concern among the elderly, posing health risks and treatment challenges. In the first part of this review, we explore the pathophysiological mechanisms linking hypertension and aging, focusing on physiological changes such as arterial stiffening, in autonomic nervous system dysfunction, disruption of the renin-angiotensin-aldosterone system, aging-induced alterations in renal function, and the impact of salt-sensitive hypertension. The mnemonic "King/A+++/Hermès" aids in recalling the pathophysiology of aging-related hypertension.

Whole-uterine versus individualized-uterine radiotherapy in locally advanced cervical cancer: clinical outcome and toxicity.

Objective: Emerging evidence has suggested the safety and efficacy of individualized-uterine radiotherapy in locally advanced cervical cancer. This study aimed to compare the clinical outcomes and gastrointestinal toxicity of whole-uterine and individualized-uterine radiotherapy in women with locally advanced cervical cancer.

Methods: A retrospective analysis was conducted on 220 patients with stage IB3 to IVA cervical cancer, treated with definitive chemoradiotherapy between 2014 and 2021 at 2 tertiary centers.

Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics.

Prenatal exposure to a high-fat diet (HFD) or microplastics can impact liver fat accumulation in offspring. This study investigates the protective effects of prenatal melatonin on liver injury in male pups resulting from maternal exposure to a HFD and microplastics. Pregnant Sprague-Dawley rats were fed either an HFD or a normal chow diet, with some groups exposed to microplastics alone or in combination with melatonin.

Impact of radiation dose to the swallowing organs on death from aspiration pneumonia in oral cavity cancer.

Objectives: Aspiration pneumonia is a major cause of non-cancer mortality following radiotherapy for head and neck cancer. This study aims to investigate its incidence and risk factors in patients receiving adjuvant radiotherapy for oral cavity cancer (OCC).

Materials And Methods: This study enrolled 1043 patients with OCC who underwent surgery and adjuvant intensity-modulated radiotherapy between 2010 and 2020 at two tertiary centers.

Study of indoor parking lot planning for electric vehicles through fire dynamics simulation.

The lack of clear regulations regarding the provision of electric vehicles parking lots, particularly in indoor parking lots, may result in inadequate fire protection and contingency planning during construction. This study investigated fire contingency planning for electric vehicle parking lots in large shopping mall, specifically scrutinizing the effects of charging pile locations, and was conducted through field research and computer simulations. Fire dynamic simulation model was utilized to simulate a fire in an indoor parking lot and investigate the impact of automatic sprinkler systems on the fire scene.

Downstream Effects of Omission of Axillary Surgery in Older Adults with Early-Stage HR+/HER2- Breast Cancer.

Purpose: Trial data demonstrate that omission of select locoregional therapies in women ≥ 70 years with early-stage HR+/HER2- breast cancer does not affect overall survival. However, the potential downstream effects of omitting sentinel lymph node biopsy (SLNB) on rates of adjuvant radiotherapy (RT) and endocrine therapy (ET) are unclear. We examined the association between SLNB omission, RT referral rates, RT receipt, and ET adherence in this population.

Identifying perturbations that boost T-cell infiltration into tumours via counterfactual learning of their spatial proteomic profiles.

Cancer progression can be slowed down or halted via the activation of either endogenous or engineered T cells and their infiltration of the tumour microenvironment. Here we describe a deep-learning model that uses large-scale spatial proteomic profiles of tumours to generate minimal tumour perturbations that boost T-cell infiltration. The model integrates a counterfactual optimization strategy for the generation of the perturbations with the prediction of T-cell infiltration as a self-supervised machine learning problem.

Integration of Anterior and Posterior Ultrasonography for Comprehensive Anterior Cruciate Ligament Visualization: A Novel Approach.

Objective: Alternative medical imaging techniques are necessary to address the limitations of magnetic resonance imaging (MRI). Therefore, this study aimed to develop an ultrasonographic method that integrates anterior and posterior approaches for measuring the entire length of the anterior cruciate ligament (ACL). We validated this method by identifying the middle ACL during arthroscopy and comparing the results to those of MRI.

Improving the Impact Resistance and Post-Impact Tensile Fatigue Damage Tolerance of Carbon Fiber Reinforced Epoxy Composites by Embedding the Carbon Nanoparticles in Matrix.

The effect of dispersing multiwalled carbon nanotubes (MWCNTs) and graphene nanoplatelets (GNPs) in the matrix on the low-velocity impact resistance and post-impact residual tensile strength of the carbon fiber reinforced epoxy composite laminates has been experimentally analyzed in this study. The composite specimens with the matrix reinforced by different nanoparticle types and various nanoparticle concentrations (0.1, 0.

Identifying threshold of CT-defined muscle loss after radiotherapy for survival in oral cavity cancer using machine learning.

Objectives: Muscle loss after radiotherapy is associated with poorer survival in patients with oral cavity squamous cell carcinoma (OCSCC). However, the threshold of muscle loss remains unclear. This study aimed to utilize explainable artificial intelligence to identify the threshold of muscle loss associated with survival in OCSCC.

Effects of Intra-Articular Stromal Vascular Fraction Injection on Clinical Symptoms and Cartilage Health in Osteoarthritic Knees: A Single-Center Pilot Study.

Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA. This study aims to assess the effects of intra-articular SVF injections on knee OA.

Regional Variation in Deescalated Therapy in Older Adults With Early-Stage Breast Cancer.

Importance: Although trial data support the omission of axillary surgery and radiation therapy (RT) in women aged 70 years or older with T1N0 hormone receptor-positive (HR+) breast cancer, potential overtreatment in older adults with frailty persists.

Objective: To determine how much geospatial variation in locoregional therapy may be attributed to region vs patient factors.

Design, Setting, And Participants: This retrospective cross-sectional study included women aged 70 years or older who were diagnosed with HR+/ERBB2-negative (ERBB2-) breast cancer from January 1, 2013, to December 31, 2017.