Publications by authors named "Yu-Chun Wang"

The global aging trend has heightened the demand for innovative healthcare solutions. This study introduces a digital healthcare platform addressing key challenges such as information silos, inadequate interdisciplinary collaboration, and care discontinuity. The platform integrates real-time data monitoring, proactive health data collection mechanisms, and intelligent tiered notifications to enhance communication among patients, families, and specialists.

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This study investigates the valley spin-polarization mechanisms in MoSmonolayers interfacing with a sputtered yttrium iron garnet (YIG) film. Structural and spectroscopic characterizations confirm successful MoSmonolayers transfer onto YIG with minimal strain issues but significant electron-doping effect, altering the exciton-trion population in MoS. Temperature-dependent spin-resolved photoluminescence (SR-PL) measurements reveal both spin accumulation and Zeeman splitting contribute to valley spin-polarization below 50 K, as evidenced by intensity asymmetry and peak splitting in SR-PL spectra.

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Objectives: This study investigates the association between extreme temperatures and the burden of age-sex-cause-specific mental disorders (MDs) from 2009 to 2019 in Taiwan and the modifying effects of socioeconomic, demographic, and geographic factors.

Methods: Daily records of MDs were collected from the National Health Insurance database. The distributed lag non-linear model was employed to assess age (0-18, 19-44, 45-64, and 65+), sex, and cause-specific (drug abuse, schizophrenia, mood disorders, and dementia) of MDs associated with extremely low (5th percentile) and high (99th percentile) temperatures considering a cumulative lag of 21 days.

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The traditional approaches rely solely on temperature measures to assess heat-related health risks; but there is a growing trend towards using bio-meteorological indices for a more comprehensive evaluation. However, the adoption of bio-meteorological indices in developing countries is considerably limited. Therefore, this study compares bio-meteorological index, the maximum Universal Thermal Climate Index (UTCI) with single-exposure maximum temperature (Tmax) for assessing heat-related mortality risks in Ahmedabad city of India.

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The biological carbon pump (BCP) plays a crucial role in carbon sequestration and sustaining water ecosystems, yet the functional genes and bacterial community assembly in (sub-)deep reservoirs BCP remain largely unexplored. In this study, carbon isotope composition (δC), High Throughput Quantitative Polymerase Chain Reaction (HT-qPCR), and 16S rRNA gene sequencing were used to explore the relationship between microbial dynamics and CO emissions in (sub-)deep reservoir systems. Despite exhibiting high primary productivity (δCᴅɪᴄ: 3.

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This comprehensive synthesis of severe COVID-19 risk factors specific to the Asia-Pacific (APAC) region addresses gaps in previous global studies, which often overlook regional demographic, epidemiological, and healthcare system variations. Three databases (PubMed, Ovid MedLine, Scopus) and two preprint platforms (BioRxiv, MedRxiv) were searched between December 1, 2019, and March 31, 2023. English-language publications from 11 APAC countries/regions (Australia, Hong Kong, Japan, Macau, New Zealand, Philippines, Singapore, South Korea, Taiwan, Thailand and Vietnam) reporting conditions associated with severe COVID-19 outcomes in adults (aged ≥16 years) were included.

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The various cone opsin genes are responsible for distinct ecological tasks, with the altered expression profiles in teleost fishes representing an excellent paradigm for studying how fishes can quickly adapt to diverse habitats within their lifecycles. The molecular mechanisms underlying transcriptional switching among cone opsin genes are still being investigated, but factors such as light conditions, developmental stages, sex hormones, and diet are known to play a role in changing cone opsin expression profiles. Based on previous research on guppies, we hypothesized that a diet rich in carotenoids could enhance expression of the opsin gene LWS in western mosquitofish (Gambusia affinis) and potentially influence female mate choice.

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Background: This study aims to assess the population attributable fraction (PAF) of diabetes on the gastrointestinal cancers overall and by specific cancer sites.

Methods: This study analyzed healthcare data from Taiwan (2006-2019) for 2,362,587 patients with and without diabetes. Gastrointestinal cancers were identified via cancer registry data.

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The study investigated the chlorine and fluorine contents in three types of industrial solid waste: textile, plastic, and paper waste, utilizing various analytical methods. Significant variations in the proportions of organic and inorganic chlorine were observed among the waste types. During heat treatment, the majority of chlorine converts to a volatile state, with fixed chlorine content showing a correlation with organic chlorine.

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Objectives: Acute liver failure poses a significant challenge in surgical critically ill patients. Treatments typically focus on physiological support and alleviation of hepatic insult. This study aims to evaluate the role of high-volume plasma exchange (HVPE) in surgical critically ill patients with medical jaundice and hepatic failure.

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Article Synopsis
  • Liriomyza trifolii is a notable pest affecting both field and greenhouse plants, but its ecological adaptability is not well understood due to limited genomic resources.
  • Researchers created a comprehensive chromosome-level genome sequence of L. trifolii, measuring 122.64 Mb, with a high gene coverage of 95.28%.
  • This genome includes nearly 12,000 protein-coding genes and offers crucial insights for managing this invasive pest effectively.
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  • * Research on Dlgap2 mutant mice showed that while their overall odor detection was similar to normal mice, they showed less interest in certain smells (banana and almond) but reacted more to unfamiliar bedding smells.
  • * The absence of DLGAP2 protein in Homo mutant mice affected their brain's response to odors, which suggests altered synaptic signaling in their olfactory systems and could inform future strategies for diagnosing and treating ASD-related olfactory issues.
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Background: Complementary medicine may enhance conventional geriatric care, but clinical guidance for incorporating Traditional Chinese Medicine (TCM) therapies remains limited. This study aimed to investigate the link between TCM body constitutions and comprehensive geriatric assessment scores in older adults.

Method: This prospective observational study recruited 100 participants aged 65 and older between January 2020 and December 2021.

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Cellular communication network factor 2 (CCN2) is a matricellular protein that plays important roles in connective tissue. CCN2 is also expressed in the nervous system; however, its role is still unclear. To explore CCN2 function in the brain, we generated forebrain-specific knockout (Fb KO) mice.

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A carboxylate-directed regioselective Heck-type alkenylation and alkenylative lactonization of ()-β,γ-unsaturated carboxylic acids by simply substrate control is reported. ()- and ()-alkenyl bromides reacted to give energetically more favorable palladacyles, allowing access to fully stereocontrolled conjugated 1,3-dienes and alkenyled γ-lactones. Mechanistic studies suggest that excellent regioselectivity may be strongly influenced by the steric factors of reactants involved in the palladacycle intermediates.

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The objective of this study is to assess the prevalence of antibiotic-resistant genes (ARGs) in the intestines of infants and the factors affecting their distribution. Breast milk and infant stool samples were collected from nine full-term, healthy mother-infant pairs. The bacterial distribution and various types of ARGs present in the samples were analyzed using metagenomic next-generation sequencing.

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Recently, a significant amount of attention has been attracted toward a third classification of magnetism, altermagnetism, due to the unique physical properties of altermagnetic materials, which are compensated collinear antiferromagnets that host time-reversal symmetry-breaking phenomena like a ferromagnet. In an altermagnetic material, through the nonrelativistic altermagnetic spin-splitting effect (ASSE), a transverse spin current is generated upon charge current injection. However, it is very challenging to experimentally establish the ASSE since it is inevitably mixed with the spin Hall effect due to the relativistic spin-orbit coupling of the material.

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Alzheimer's disease is the most common cause of dementia in the elderly, prompting extensive efforts to pinpoint novel therapeutic targets for effective intervention. Among the hallmark features of Alzheimer's disease is the development of neurofibrillary tangles comprised of hyperphosphorylated tau protein, whose progressive spread throughout the brain is associated with neuronal death. Trans-synaptic propagation of tau has been observed in mouse models, and indirect evidence for tau spread via synapses has been observed in human Alzheimer's disease.

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Article Synopsis
  • This study in Taiwan analyzed emergency room visits (ERVs) related to temperature across various job groups from 2009 to 2018.
  • The results indicated that ERVs for all causes and respiratory issues increased with higher temperatures, particularly among younger and outdoor workers, while circulatory disease risks peaked during cold spells, especially for female workers.
  • These findings demonstrate the nuanced relationship between temperature and health risks in different occupations, underscoring the need for targeted public health strategies.
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In this study, we investigated the concentration of airborne influenza virus in daycare centers and influencing factors, such as common cold prevalence, air pollutants, and meteorological factors. A total of 209 air samples were collected from daycare centers in Kaohsiung and the influenza virus was analyzed using real-time quantitative polymerase chain reaction. Air pollutants and metrological factors were measured using real-time monitoring equipment.

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  • * This study confirmed that CsNAC086 can self-activate but does not directly regulate CsFLS expression, as shown in yeast transcription assays.
  • * Silencing CsNAC086 led to reduced flavonol levels, while overexpressing it in tobacco increased flavonol concentration, highlighting its significance in developing high-flavonol tea plant varieties.
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  • Climate change is causing global temperature increases and extreme weather, leading to heightened heat stress, which poses serious public health risks.
  • Studies primarily focus on air temperature, but the Universal Thermal Climate Index (UTCI) provides a more comprehensive measure of heat strain.
  • The Asia-Pacific region shows rising air temperatures from 1990 to 2019, but UTCI trends are less severe, suggesting other factors may mitigate heat stress despite increasing temperatures, with significant seasonal variations linked to the El Niño Southern Oscillation (ENSO).
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Spatial analysis of infectious diseases can play an important role in mapping the spread of diseases and can support policy making at local level. Moreover, identification of disease clusters based on local geography and landscape forms the basis for disease control and prevention. Therefore, this study aimed to examine the spatial-temporal variations, hotspot areas, and potential risk factors of infectious diseases (including Viral Hepatitis, Typhoid and Diarrhea) in Ahmedabad city of India.

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Background: The aim of the study was to investigate whether the expression of CD27CD38 in interferon (IFN)-γCD4 T cells stimulated by the specific antigen early secreted antigenic target-6 (ESAT-6)/culture filter protein-10 (CFP-10) could be a potential new therapeutic evaluation indicator for anti-tuberculosis (TB) treatment.

Methods: Newly diagnosed active pulmonary TB patients, latent TB infection (LTBI) and healthy controls were enrolled from January 2021 to December 2021. PTB patients were treated by standard anti-TB regimen 2HREZ/4HR (2 months of isoniazid (H), rifampin (R), ethambutol (E), and pyrazinamide (Z) followed by 4 months of isoniazid (H) and rifampin (R)).

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Background: Domestic cats are important companion animals in modern society that live closely with their owners. Mislabeling of pet food can not only harm pets but also cause issues in areas such as religious beliefs and natural resource management. Currently, the cat food market is booming.

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