Publications by authors named "Yu-Chao Hou"

Background: Microvascular invasion (MVI) is a critical prognostic factor affecting long-term survival in patients with hepatocellular carcinoma (HCC). Despite its clinical significance, the optimal postoperative adjuvant therapy for HCC patients with MVI remains undefined. This study aimed to evaluate the efficacy and safety of postoperative adjuvant transarterial chemoembolization (PA-TACE) combined with lenvatinib vs PA-TACE alone in HCC patients with MVI.

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  • Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, and the enzyme CAD plays a significant role in its development, although its specific function in HCC was previously unclear.
  • Analysis of data from 424 HCC cases showed that high CAD levels correlate with poor patient prognosis and are linked to immune response dynamics, indicating that CAD levels can influence treatment sensitivity to certain therapies.
  • Further experiments revealed that knocking down CAD reduced HCC cell growth and migration, suggesting that CAD acts as an oncogene in HCC progression and could serve as a valuable target for future treatments.
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Objectives: To explore the effects of the combination of -sea and front- points on the feeding compliance rate, the intra-abdominal pressure, the enteral nutrition tolerance score, the score of acute physiological and chronic health evaluation (APACHE)-Ⅱ and gastrointestinal function impairment grade in the patients with enteral nutrition feeding intolerance (ENFI) of critical illness and evaluate clinical effect on ENFI after acupuncture at the sea and front- points.

Methods: Seventy patients of ENFI were randomized into a control group and an observation group, 35 cases in each one. In the control group, the patients were treated with routine regimen combined with intestinal nutrition support.

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  • Hepatocellular carcinoma (HCC) is a common cancer worldwide, and this study explores the relationship between a specific type of cell death called disulfidptosis and long non-coding RNAs (lncRNAs) in HCC to find new biomarkers for immune response and prognosis.
  • The research integrated transcriptomic data from The Cancer Genome Atlas (TCGA) to identify disulfidptosis-associated lncRNAs and created a predictive model using advanced statistical analyses, which was then tested for its effectiveness in understanding immune response and drug sensitivity.
  • The resulting model identified four key lncRNAs with strong diagnostic potential for HCC, suggesting that it could help personalize immunotherapy and improve treatment decisions for patients by considering their
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  • Early and late recurrence of hepatocellular carcinoma (HCC) shows different outcomes, and determining the early recurrence timeframe is crucial, particularly for patients with microvascular invasion (MVI).
  • The study analyzed 292 patients to establish the early recurrence interval and confirmed the results with an additional 421 patients using survival analysis techniques, identifying MVI as a significant risk factor.
  • Findings suggest that for HCC patients with MVI, a 13-month period post-surgery is a practical early recurrence cutoff, and adjuvant TACE treatment during this time can improve survival rates compared to surgery alone.
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Background: Cancer-related pain is one of the primary symptoms of patients with hepatocellular carcinoma (HCC). Previous studies have shown that transcutaneous electrical acupoint stimulation (TEAS) is effective in treating patients with acute or chronic pain. In China, it is indispensable to evaluate the efficacy of TEAS in combination with opioids for the treatment of moderate to severe HCC-related pain.

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To summarize the application value of acupuncture in perioperative stress response. Perioperative acupuncture can not only effectively relieve pain and stress response during operation, but also relieve psychological stress response represented by preoperative anxiety before operation, and regulate adaptive immune response after operation. Acupuncture, as a safe non-drug therapy, shows its core advantage of participating in the multidisciplinary intervention of enhance recovery after surgery (ERAS).

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As an unpleasant subjective feeling and emotional experience, pain has a negative impact on the physical and mental health of patients. In the early years, the research concerning pain mostly focused on the sensory-discriminative component. With the development of modern medicine, people found that the generation of affective-emotional component of pain has its unique physiological mechanism, and thus carried out a lot of in-depth research.

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Chronic atrophic gastritis (CAG) is a common digestive disease in clinic. Previous experimental and clinical studies have shown that acupuncture has a positive effect for CAG. Apoptosis of gastric mucosal tissue has been shown to play an important role in the process of gastric atrophy and possibly further carcinogenesis in CAG, and the circular RNA (circRNA), a novel class of non-coding RNA, has been confirmed to play a regulatory role in the downstream pathway of apoptosis by many stu-dies.

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