Insulin resistance and the risk of incident depression: the role of age, glycemic status, and adiposity in a prospective cohort study.

Background: Despite emerging evidence, the causal relationship between insulin resistance and depression remains controversial. This study aimed to investigate whether insulin resistance is associated with increased risk of incident depression and whether the association is affected by potential moderators.

Methods: This multi-centered prospective cohort study analyzed health screening data from 233,452 Korean adults participating in the Kangbuk Samsung Health Study from 2011 to 2022.

The association between physical activity and burnout among healthy Korean employees: Identifying recommended physical activity ranges.

Background: Burnout is a growing public health issue with serious health and economic burden globally. Although physical activity has been shown to affect mental health outcomes, its association with burnout remains unclear. The aim of this study was to examine the association between physical activity (PA) and burnout and to explore PA ranges associated with lower burnout.

The Stress and Adversity Inventory for Adults (Adult STRAIN) in Korean: Initial Validation and Associations with Psychiatric Disorders.

Background/objectives: Stressors occurring across the life course are considered to have a cumulative impact on health, but there is no instrument for assessing lifetime stressor exposure in Korea. Therefore, we validated the Stress and Adversity Inventory (Adult STRAIN) in Korean.

Methods: We translated the Adult STRAIN into Korean and examined its concurrent, predictive, and comparative predictive validity in 218 Korean adults (79 men, 139 women; = 29.

Psychological Distress Trends and Effect of Media Exposure Among Community Residents After the Seoul Halloween Crowd Crush.

Background: It is unclear how exposure to and perception of community trauma creates a mental health burden. This study aimed to examine the psychological distress trends among community residents in acute stress reaction, acute stress disorder, and post-traumatic stress disorder phases following the Seoul Halloween crowd crush.

Methods: A three-wave repeated cross-sectional survey was conducted with participants after the incident.

Association between intra-individual variability and prefrontal cortex activity measured by functional Near Infrared Spectroscopy (fNIRS) in children with ADHD.

This study uses fNIRS to determine whether there is a difference in the relationship between intra-individual variability and frontal lobe activity between ADHD patients and typically developing children. A total of 28 subjects (14 in ADHD patient group and 14 in control group) participated in this study. The subjects were tested for K-SADS and intelligence, and then the frontal lobe activity of the subjects was measured by continuous performance test, using functional near-infrared spectroscopy (NIRSIT).

Deformation Behavior and Microstructure of 6061 Aluminum Alloy Processed by Severe Plastic Deformation Using Biaxial Alternate Forging.

The deformation behavior and microstructure of 6061 aluminum alloy processed by severe plastic deformation (SPD) using biaxial alternate forging that can evaluate the forming limit and mechanical properties of alloys, simultaneously, were investigated in this study. A finite element (FE) analysis on the biaxial alternating forging process, considering the strain-hardening coefficient and forging pass of the material, was conducted. When the strain-hardening coefficient is 0, an average effective strain of 440% was found within a diameter of 4 mm in the core of the workpiece after eight passes, while it was 300% at the same pass number when the strain-hardening coefficient was 0.

Gender Differences in the Association between Workplace Bullying and Depression among Korean Employees.

Workplace bullying is a prevalent issue with a significant impact on employees' mental health. This study aimed to explore the relationship between workplace bullying and the prevalence of depression, with a particular focus on the role of gender. A total of 12,344 Korean employees aged 19-65 years were included in the study.

-Acetylglucosamine and its dimer ameliorate inflammation in murine colitis by strengthening the gut barrier function.

Ulcerative colitis (UC) is a chronic gastrointestinal disease whose incidence is increasing rapidly worldwide. Anti-inflammatory medications, including 5-aminosalicylic acid (5-ASA), corticosteroids, and immunosuppressants, are used for its treatment; however, new alternatives would be required due to the serious side effects of some of these medications. -Acetylglucosamine (NAG) is an amino sugar composed of mucin that is secreted by intestinal epithelial cells.

Occupational stress and depression of Korean employees: Moderated mediation model of burnout and grit.

Background: The present study investigated an interpersonal model of development of depressive symptoms in employees, where occupational stress affects burnout, which in turn affects risk for depression, and whether this mediation is moderated by grit.

Methods: A total of 11,421 participants, aged 19 to 65 years, who were employees of 18 private companies and local government organizations in Korea were included. They completed questionnaires, including the Korean version of occupational stress scale, Oldenburg Burnout Inventory, Center for Epidemiologic Studies Depression scale and Grit scale.

Perceived Control and Work-Related Stress Mediate the Effects of Grit on Depression among Employees.

We developed and evaluated an interpersonal model of depression in employees, where passion and perseverance affect occupational stress and perceived control, which in turn affect risk of depression. The participants were employees of 18 private companies and local government organizations in Korea aged 19 to 65 years. A total of 11,422 participants completed questionnaires including the Korean version of the Grit scale, the occupational stress scale, the perceived control subscale in the perceived stress scale, and the Center for Epidemiologic Studies Depression Scale.

Low molecular weight chitooligosaccharide inhibits infection of SARS-CoV-2 in vitro.

Aims: The discovery of antiviral substances to respond to COVID-19 is a global issue, including the field of drug development based on natural materials. Here, we showed that chitosan-based substances have natural antiviral properties against SARS-CoV-2 in vitro.

Methods And Results: The molecular weight of chitosan-based substances was measured by the gel permeation chromatography analysis.

Evaluation of the Dose-Dependent Effects of Fermented Mixed Grain Enzyme Food on Adiposity and Its Metabolic Disorders in High-Fat Diet-Induced Obese Mice.

Ancient traditions showed that fermented enzyme foods have beneficial health effects on the body. However, only a few studies have reported on its impact on weight loss and metabolic syndrome. Therefore, it is necessary to verify whether diet supplementation with fermented enzyme foods can have a beneficial functional impact on the body.

Bidirectional association between blood pressure and depressive symptoms in young and middle-age adults: A cohort study.

Aims: To evaluate the bidirectional relationship between blood pressure (BP) and depressive symptoms using a large prospective cohort study.

Methods: Prospective cohort study was performed in 276 244 adults who participated in a regular health check-up and were followed annually or biennially for up to 5.9 years.

Enhanced alcohol degradation and hepatic protective effects of an -derived product, CureZyme-ACE, in an acute intoxication rat model.

Excessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), (AP)-derived product, in acute intoxication rats. The ethanol and acetaldehyde levels of serum were lower in rats treated with CA than those who only treated ethanol.

The association of occupational stress and sleep duration with anxiety symptoms among healthy employees: A cohort study.

The aim of this study is to identify occupational stress associated with the development of new-onset anxiety symptoms and the dose-response relationship between sleep duration and the onset of anxiety symptoms. Data from 29,251 healthy employees who had undergone at least two comprehensive health examinations at Kangbuk Samsung Hospital Health Screening Center were analysed. Anxiety symptoms were assessed using the Beck Anxiety Inventory.

The Relationship between Serum Vitamin D Levels, C-Reactive Protein, and Anxiety Symptoms.

Objective: The aim of study is to investigate the relationship between serum vitamin D, c-reactive protein (CRP) levels, and anxiety symptoms.

Methods: Serum vitamin D and CRP levels of 51,003 Korean adult participants were collected retrospectively. Anxiety symptoms were assessed using the Korean version of Beck Anxiety Inventory.