High-Yield Convenient Mass Production of High-Quality Homogenous Human Induced Pluripotent Stem Cell Spheroids under Rho-Associated Kinase Inhibitor-Free 3D Culture Enabled by Micropatterning and Cold-Triggered Chemical-Free Cell Detachment.

Human induced pluripotent stem cells (hiPSCs) show great promise for personalized cell-based medicine, as they can be derived from easily accessible somatic cells and differentiated into all three germ layers without ethical concerns. This requires mass production of hiPSCs in 3D. However, contemporary methods for 3D culture result in hiPSC spheroids with significant size heterogeneity that is undesired for controlled differentiation and require the use of a high concentration of Rho-associated kinase inhibitor (RI) to improve the cell viability.

Thermomagnetic liquid metal switches with fast bidirectional response.

Traditional thermal switches usually suffer from long-time and unidirectional response. Herein, we combined liquid metals with magnetic NiMnIn particles and developed a thermomagnetic liquid metal. These materials not only show excellent fluidity and electrical conductivity, but also exhibit fast response at a tuneable temperature that traditional magnetic liquid metals do not have.

Thermal Gradient-Driven Heterogeneous Actuation of Liquid Crystal Elastomers for a Crawling Robot.

Emerging soft robots based on liquid crystal elastomers (LCEs) exhibit remarkable capabilities for large reversible shape morphing, enabling them to adapt to complex environments and perform diverse tasks such as locomotion and camouflage. Despite extensive studies, current methods for locally controlled actuation of LCE-based soft robots often involve intricate structural design, complex programming of LCEs, incorporation of multiple materials, or complex actuation methods. Here, we present a simple and efficient approach to achieve multiple deformation modes within a simply programmed LCE structure by harnessing Joule heating-induced thermal gradients across the LCE volume.

Magnetically tightened form-stable phase change materials with modular assembly and geometric conformality features.

Phase change materials have attracted significant attention due to their promising applications in many fields like solar energy and chip cooling. However, they suffer leakage during the phase transition process and have relatively low thermal conductivity. Here, through introducing hard magnetic particles, we synthesize a kind of magnetically tightened form-stable phase change materials.

Dissolution Effect of Alteplase on Arterial Blood Clot Model of Hypertensive Intracerebral Hemorrhage Patients .

Objective: To explore the dissolution effect of alteplase (rt-PA) on arterial blood clots of patients with hypertensive cerebral hemorrhage and analyze the optimal concentration and action time of rt-PA for intracranial hematomas.

Methods: The arterial blood of 35 patients with confirmed hypertensive cerebral hemorrhage were collected, centrifuged, and the serum was aspirated to prepare the blood clot model. The 0.

Mussel-Inspired Multifunctional Integrated Liquid Metal-Based Magnetic Suspensions with Rheological, Magnetic, Electrical, and Thermal Reinforcement.

Magnetic liquid metal is regarded as a promising material due to its integration of fluidic, metallic, and magnetic properties simultaneously. Previously, few methods of fabricating magnetic liquid metal have been proposed. However, either the alloying reaction inside the matrix or the poor performance in electrical and thermal conduction is troublesome in practical applications.

Liquid Metal-Based Magnetorheological Fluid with a Large Magnetocaloric Effect.

Herein, liquid metal and MnFeNiGeSi particles with a large magnetocaloric effect are adopted to prepare a novel magnetocaloric suspension named liquid metal-based magnetorheological fluid (LMRF), which can well solve the problems of brittleness, low thermal conductivity, and poor machinability in classical magnetocaloric materials. The low melting point and high boiling point of liquid metal could significantly widen the operating temperature range of such a fluid. As a carrier, the high thermal conductivity, low viscosity, and large density of liquid metal display advantageous to heat transfer.

Hypothalamic paraventricular nucleus stimulation reduces intestinal injury in rats with ulcerative colitis.

Aim: To investigate the effect and mechanism of stimulation of the hypothalamic paraventricular nucleus with glutamate acid in rats with ulcerative colitis (UC).

Methods: The rats were anesthetized with 10% chloral hydrate via abdominal injection and treated with an equal volume of TNBS + 50% ethanol enema, injected into the upper section of the anus with the tail facing up. Colonic damage scores were calculated after injecting a certain dose of glutamic acid into the paraventricular nucleus (PVN), and the effect of the nucleus tractus solitarius (NTS) and vagus nerve in alleviating UC injury through chemical stimulation of the PVN was observed in rats.

N-[4-Chloro-3-(trifluoro-meth-yl)phen-yl]-2,2-dimethyl-propanamide.

In the title compound, C(12)H(13)ClF(3)NO, the C-C-N-C torsion angle between the benzene ring and the pivaloyl group is -33.9 (5)°. In the crystal, molecules are linked via N-H⋯O hydrogen bonds to form chains running parallel to the c axis.