Publications by authors named "Yong-Pyo Lee"
Background: In the tumor microenvironment, regulatory T cells (Treg cells), a small subset of CD4+ T cells, can interrupt antitumor immune reactions by interacting with various other immune cells. The present study aimed to determine the expression level of Treg cells in myeloma compared with that in normal control.
Methods: Peripheral blood samples from 90 healthy adults and marrow aspiration samples from 13 patients newly diagnosed with myeloma were collected.
Rationale: Esophageal and head and neck cancers often coexist due to field cancerization, which causes multiple squamous cell carcinomas (SCCs) in the upper aerodigestive tract. However, guidelines for the differential diagnosis and optimal treatment of synchronous esophageal and head and neck SCC are lacking. This study highlights the diagnostic and therapeutic challenges of these coexisting malignancies.
View Article and Find Full Text PDFTargeted Suppression of CEACAM6 via pHLIP-Delivered RNAs in Pancreatic Ductal Adenocarcinoma.
Medicina (Kaunas)
March 2025
: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is involved in pancreatic cancer progression and is an attractive therapeutic target for pancreatic cancer. In this study, we evaluated the therapeutic efficacy of small-interfering RNA (siRNA) targeting CEACAM6 (siCEACAM6) and the CEACAM6-suppressive microRNA-29a (miR-29a) in a pancreatic ductal adenocarcinoma xenograft mouse model using pH-low insertion peptide (pHLIP) technology, which targets the acidic tumor microenvironment. : The delivery vectors for siRNA and miRNA were constructed by conjugating the peptide nucleic acid forms of siCEACAM6 and miR-29a to a peptide with a pHLIP, enabling the transport of siRNA and miRNA across the plasma membrane.
View Article and Find Full Text PDFPurpose: Primary mediastinal large B-cell lymphoma (PMBCL) is a rare subtype of diffuse large B-cell lymphoma. Radiation therapy (RT) has served as the primary treatment option for PMBCL; however, its role has been questioned with the advent of intensified immunochemotherapy. This study aimed to investigate the role of consolidative RT in the primary treatment of PMBCL.
View Article and Find Full Text PDFPurpose: Claudin 18.2 (CLDN18.2) has emerged as a promising therapeutic target for CLDN18.
View Article and Find Full Text PDFSynchronous pancreatic adenocarcinoma and duodenal mucosa‑associated lymphoid tissue lymphoma: A case report.
Medicine (Baltimore)
December 2024
Rationale: Duodenal mucosa-associated lymphoid tissue (MALT) lymphoma is a rare condition. Simultaneous presence of pancreatic ductal adenocarcinoma along with duodenal MALT lymphoma has not been documented in the scientific literature. We report an exceptionally rare case of synchronous duodenal MALT lymphoma and pancreatic ductal adenocarcinoma.
View Article and Find Full Text PDFBackground: Esophagogastric and pancreaticobiliary cancers are associated with chronic blood loss, poor nutrition, and surgical interventions that interfere with iron absorption. Patients with these cancers often have a higher incidence of chemotherapy-induced anemia (CIA) than patients with other malignancies.
Objectives: To investigate the efficacy of intravenous iron or erythropoietin-stimulating agents (ESA) for CIA treatment in patients with esophagogastric or pancreaticobiliary cancer.
Article Synopsis
- The study explores the potential of a new DNA methylation assay called Epi-TOP for diagnosing pancreatic ductal adenocarcinoma (PDAC) using both tissue and plasma samples.
- It involved 46 patients and demonstrated that a combination of seven specific epigenetic biomarkers could accurately differentiate PDAC from normal pancreatic tissues with high sensitivity (93.5%) and specificity (96.7%).
- The assay also showed promising results for analyzing cell-free DNA (cfDNA) from plasma, achieving 90% sensitivity and 95% specificity, suggesting its potential as a blood-based diagnostic tool for PDAC.
Article Synopsis
- Hand-foot syndrome (HFS) and hand-foot skin reaction (HFSR) are common side effects of cancer treatment that negatively affect patients' quality of life, and a study tested an anti-inflammatory cream called ATPC for treatment.
- The study involved 60 patients with mild HFS/HFSR who were randomly assigned to receive either the ATPC or a placebo, and their conditions were monitored over 9 weeks.
- Results indicated that ATPC significantly reduced the incidence of more severe HFS/HFSR compared to the placebo group, suggesting it could be an effective treatment for managing these side effects in cancer patients.*
Article Synopsis
- The study evaluated the effectiveness of ibrutinib for treating relapsed or refractory mantle cell lymphoma (MCL) in a group of 42 patients, showing a 69% overall response rate with notable survival outcomes.
- Key findings include a median progression-free survival of 16.4 months and overall survival of 50.1 months, but older patients and those with certain risk factors had worse outcomes.
- The study emphasizes the need to assess patient characteristics before using ibrutinib and suggests that early relapse indicates a need for new treatment options.
Article Synopsis
- The text discusses a rare type of lymphoma called intravascular large B-cell lymphoma (IVLBCL), particularly the Asian variant, which is associated with severe symptoms and bone marrow involvement, but less commonly affects the central nervous system (CNS).
- It presents a case study of a 67-year-old woman who experienced cognitive decline, fever, and bicytopenia, with imaging suggesting CNS issues despite no malignant cells in her cerebrospinal fluid; evidence of the disease was found in her bone marrow and through imaging and biopsy.
- The conclusion emphasizes that recognizing signs of IVLBCL and an accurate diagnosis are crucial for timely treatment, highlighting the importance of thorough CNS examination during diagnosis.
Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea.
Osong Public Health Res Perspect
June 2023
Article Synopsis
- A study conducted in 2021 in the Honam region of South Korea assessed the effectiveness of COVID-19 vaccines and monitored changes in dominant virus strains.
- Results showed a high vaccination rate of 88.6%, with overall vaccine effectiveness at 98.7% and a breakthrough infection rate of just 0.16%.
- The emergence of new variants like Delta and Omicron impacted vaccine effectiveness over time, but receiving booster doses helped restore antibody levels, ensuring continued protection.
Article Synopsis
- Primary testicular lymphoma, mainly diffuse large B cell lymphoma (DLBCL), is rare and poses challenges like central nervous system (CNS) recurrence despite established treatment protocols.
- A study of 65 patients showed that those with stage I disease and a low prognostic score had better survival, and effective treatments included orchiectomy, chemotherapy, and radiation therapy.
- CNS recurrence occurred in 15% of patients without identifiable risk factors, indicating a need for improved prevention strategies beyond current therapies.
Article Synopsis
- Follicular lymphoma (FL) often results in remissions followed by relapses, and there's no agreed-upon treatment strategy for patients who don't respond to initial treatments.* -
- A study of 70 patients showed that those experiencing disease progression within the first 24 months had significantly lower overall survival rates, particularly after conventional post-relapse treatments.* -
- Autologous stem cell transplantation (ASCT) improved survival for patients with early progression, and participation in clinical trials was associated with better outcomes regardless of the treatment line.*
Article Synopsis
- Community mitigation measures during the COVID-19 pandemic led to a decrease and delayed occurrence of respiratory viruses, including human parainfluenza virus type 3 (HPIV3) in Gwangju, Korea, with a peak outbreak observed in September-October 2021.
- Genetic analyses of 129 HPIV3 strains from 2018 to 2021 revealed reduced diversity in 2021 compared to previous years, likely due to limited virus inflow from other regions as a result of mitigation efforts.
- The 2021 HPIV3 strains showed significant genetic similarities to older sequences from Japan and India, highlighting the potential risk of a new lineage disrupting community immunity and emphasizing the need for ongoing viral monitoring.
Article Synopsis
- * Tfh cell origin lymphomas include angioimmunoblastic T-cell lymphoma (AITL), follicular peripheral T-cell lymphoma (F-PTCL), and nodal peripheral T-cell lymphoma with Tfh phenotype, with AITL being the most common.
- * A study analyzing 198 Tfh cell lymphoma patients found that while the AITL score was more effective for risk classification than other prognostic tools, there is still a lack of clear guidelines for predicting patient outcomes.
Article Synopsis
- Gemcitabine and cisplatin are the standard first-line treatments for advanced biliary tract cancer (BTC), but many patients experience disease progression, leading to the need for effective second-line therapies.
- A phase II study evaluated the modified dose of FOLFIRINOX (mFOLFIRINOX) in 34 patients who did not respond to the initial treatment, revealing a median progression-free survival of 2.8 months and overall survival of 6.2 months.
- The treatment had a moderate disease control rate of 61.7%, but half the patients received less than three cycles due to rapid disease progression, and the main adverse effects were hematopoietic-related.
Introduction: Concurrent chemo-radiotherapy (CCRT) with temozolomide (TMZ) is a standard first-line treatment for high-grade glioma. However, if CCRT with TMZ treatment fails, second-line treatment options have limited value. Bevacizumab plus irinotecan is the only available treatment option for such patients.
View Article and Find Full Text PDFArticle Synopsis
- Trastuzumab has significantly improved the survival rates of patients with HER2-positive breast cancer, and its combination with pertuzumab and taxanes (THP) is now a standard treatment for metastatic cases globally, as established by the CLEOPATRA trial.* -
- A study was conducted on 228 Korean HER2-positive metastatic breast cancer patients treated with THP between 2008 and 2020, showing a median overall survival of 58.3 months and a progression-free survival of 19.1 months.* -
- The findings revealed an 86.8% overall response rate, with some patients experiencing better outcomes after prolonged treatment, while similar adverse events to previous studies were reported; long-term
Article Synopsis
- Safflower (L.) has historical uses in treating vascular issues related to the heart, brain, and diabetes, and this study explores its potential in reducing vascular inflammation in human cells.
- The ethanol extract of safflower (ECT) was found to lower the adhesion of leukocytes and reduce key cell adhesion molecules, indicating a protective effect on blood vessel health.
- ECT also decreases oxidative stress and suppresses harmful signaling pathways, suggesting it could be a promising natural treatment for vascular inflammation, but more research is needed to identify the most effective compounds.
Article Synopsis
- * In a study involving 10 patients with RET fusion-positive non-small cell lung cancer, most exhibited positive responses to pralsetinib, with seven out of nine showing partial responses and only one patient discontinuing treatment.
- * Notably, two patients developed extrapulmonary tuberculosis during treatment, which was successfully managed with anti-TB medication, highlighting the need for further research to understand the relationship between pralsetinib therapy and TB development.
Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia.
Int J Hematol
September 2021
Cutaneous T-cell lymphomas (CTCLs) are a group of T-cell lymphomas with low incidence. Due to their indolent characteristics, treatment strategies have not yet been established for advanced CTCLs. In this study, relative incidence of CTCLs in Asia was estimated and the therapeutic outcomes presented based on various treatments currently used in clinics for advanced CTCLs.
View Article and Find Full Text PDFArticle Synopsis
- * A total of 24 patients were analyzed, with a complete response rate of 21% and an overall response rate of 38%, primarily among those with DLBCL, as no patients with transformed follicular lymphoma showed a response.
- * Although treatment resulted in manageable hematologic toxicities and no serious adverse events, it highlighted the need for additional therapies to improve patient outcomes, particularly given the short median survival times observed post-treatment.
Article Synopsis
- The study investigates the ongoing risk of polio re-emergence, particularly in regions previously declared polio-free, by examining acute flaccid paralysis (AFP) cases in Korea from 2012 to 2019.
- A total of 637 AFP patients under 15 were analyzed, with non-polio enterovirus (NPEV) detected in 33.4% of cases, predominantly the EV-A71 strain.
- The findings underscore the importance of effective AFP surveillance in understanding non-polio enterovirus-related neurological diseases and monitoring for potential polio outbreaks.
Article Synopsis
- Living kidney donors provide a crucial source of organs in places with limited deceased donor availability, but the long-term impacts of donating a kidney, particularly on renal function, are not fully understood.
- A study reviewed data from 1,175 living kidney donors to assess how their renal function changed after surgery, finding that the average e-GFR dropped significantly right after donation but improved over time.
- Results indicated that while a small percentage experienced renal failure, most donors saw gradual recovery of kidney function over the years, suggesting that the body compensates for the loss of one kidney regardless of factors like obesity or gender.