Publications by authors named "Yi-Bin Lin"
N6-methyladenosine Methyltransferase METTL3 Enhances PTGER2 Expression to Increase Ovarian Cancer Stemness and Chemoresistance.
Front Biosci (Landmark Ed)
September 2023
Article Synopsis
- Ovarian cancer is a significant health issue, being the second leading cause of death among gynecologic cancers, largely due to cancer stemness and resistance to chemotherapy.
- This study explores the role of N6-methyladenine (m6A) RNA methylation and prostaglandin E receptor 2 (PTGER2) in ovarian cancer progression through bioinformatics, cellular, and molecular experiments.
- The findings highlight PTGER2 as an oncogene that correlates with poor prognosis and enhanced metastatic behavior in ovarian cancer, suggesting it could be a new target for treatment strategies.
Background: Stemness and chemoresistance contribute to cervical cancer recurrence and metastasis. In the current study, we determined the relevant players and role of N-methyladenine (mA) RNA methylation in cervical cancer progression.
Methods: The roles of mA RNA methylation and centromere protein K (CENPK) in cervical cancer were analyzed using bioinformatics analysis.
LncRNA TLR8-AS1 promotes metastasis and chemoresistance of ovarian cancer through enhancing TLR8 mRNA stability.
Biochem Biophys Res Commun
June 2020
Ovarian cancer is diagnosed as the most deadly gynecological tumor. Ovarian cancer metastasis affects chemoresistance and confers poor patient prognosis. In present work, we intended to elucidate whether long non-coding RNAs (lncRNAs) TLR8-AS1 regulated cell metastasis and chemoresistance of ovarian cancer, and uncover the molecular mechanism of TLR8-AS1 in the modulation of ovarian cancer progression.
View Article and Find Full Text PDF[Colonization with arbuscular mycorrhizal fungus Funneliformis mosseae enhanced the responses of tomato plants to mechanical wounding].
Ying Yong Sheng Tai Xue Bao
November 2018
Insect herbivore feeding causes mechanical damage to plants, which can activate plant defense responses. Whether symbiosis with beneficial microorganisms can enhance the responses of plants to mechanical damage is of importance for plant anti-herbivore resistance. In this study, defense responses of tomato (Lycopersicon esculentum) plants to mechanical wounding was investigated after the tomato roots being infected by arbuscular mycorrhizal fungus (AMF) Funneliformis mosseae.
View Article and Find Full Text PDF[Expression and clinical significance of decorin in stress urinary incontinence].
Zhonghua Fu Chan Ke Za Zhi
August 2005
Objective: To observe the relation between content of type III collagen and expression of decorin in paraurethral connective tissue in patients with stress urinary incontinence (SUI).
Methods: Transvaginal biopsies were obtained from the paraurethral connective tissue in 43 SUI and non-SUI control women. The concentration of type III collagen was determined by immunohistochemical technique, electrophoretic separation and quantification.