Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU).

Background: Practice and delivery of critical care in Asia varies according to healthcare structure, income setting, and cultural factors. Identifying research priorities specific to ICU patients and healthcare workers in Asia is needed to guide advancement of critical care in the region.

Methods: This was an international cross-sectional survey study with adapted methods from nominal group techniques.

Prevalence and outcomes of acute kidney injury in cirrhotic patients admitted to the intensive care unit: A 16-year retrospective cohort study in Saudi Arabia.

ObjectiveAcute kidney injury (AKI) in patients with cirrhosis is associated with increased morbidity and mortality in critically ill patients. There is a considerable variation in the reported prevalence of AKI across studies. We provide a unique regional analysis, addressing gaps in AKI data in critically ill cirrhotic patients from the Middle East.

Outcomes of patients admitted to the intensive care unit with sepsis and septic shock in Saudi Arabia over 16 years.

Background: We examined the outcomes of patients with sepsis and septic shock admitted to the intensive care unit (ICU) in a tertiary care hospital in Saudi Arabia over 16 years.

Methods: A retrospective cohort study was carried out using data collected prospectively in an ICU database. We included all patients admitted between January 1, 2002, and December 31, 2017, with sepsis defined by Sepsis-3 criteria.

Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy.

Objective: The aim of this study was to examine the prevalence and incidence of diarrhea, diarrhea risk factors, processes of care, and clinical outcomes associated with diarrhea in invasively ventilated patients in the ICU.

Design: Bedside nurses prospectively documented each patient's bowel movement (BM) using the Bristol Stool Chart type and number. Research Coordinators collected baseline and daily data evaluating risk factors for diarrhea and patient outcomes.

Coenrollment in a critical care trial: Characteristics and consequences.

Background: Objectives of this study were to determine the characteristics of patients, centers and studies involved in coenrollment, and the association of coenrollment with trial metrics and patient outcomes.

Methods: This pre-planned study within a stress ulcer prophylaxis trial testing pantopazole used descriptive analyses and multilevel regression analysis to examine patterns and predictors of coenrollment among patients in an intensive care unit (ICU).

Results: Among 4821 trial participants, 1719 (35.

Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial.

Introduction: Tocilizumab improves outcomes in critically ill patients with COVID-19. Whether other immune-modulator strategies are equally effective or better is unknown.

Methods: We investigated treatment with tocilizumab, sarilumab, anakinra and no immune modulator in these patients.

Risk Factors for Patient-Important Upper Gastrointestinal Bleeding.

Patient-important gastrointestinal bleeding is an endpoint developed by patients and family members; however, risk factors for this outcome are unknown. We sought to identify risk factors for patient-important upper gastrointestinal bleeding among invasively ventilated adults. This preplanned regression analysis of an international trial database evaluated baseline and time-varying risk factors in the preceding 3 days for patient-important upper gastrointestinal bleeding, accounting for illness severity and the competing risk of death.

Sex-based outcomes of obesity in critically ill patients: a retrospective cohort study.

Background: Obesity is increasingly prevalent among critically ill patients, generally more common among females than males. Whether the patient's sex influences the outcome in these patients is unclear.

Objective: Evaluate the outcomes of critically ill-patients with obesity admitted to the intensive care unit (ICU).

Mean arterial pressure targets in intensive care unit patients receiving noradrenaline: An international survey.

Objective: This study aimed to evaluate intensive care doctors' views about a large-scale pragmatic minimum mean arterial pressure (MAP) targets trial and their attitudes and beliefs about minimum MAP targets in different clinical scenarios.

Design: An online survey was conducted.

Setting And Participants: An online survey was distributed to intensive care doctors in sites participating in a large-scale international randomised clinical trial evaluating oxygen therapy targets in 15 countries and to additional intensive care clinicians from Canada.

Characteristics, management and outcomes of central versus peripheral pulmonary embolism: a retrospective cohort study.

Background: The location of thrombus in acute pulmonary embolism (PE) is a debatable prognostic factor. We compared the characteristics and outcomes of hospitalized patients with central versus peripheral PE.

Methods: This retrospective study evaluated patients with acute PE diagnosed by CT pulmonary angiography who were hospitalized between 01/01/2016 and 31/12/2022.

Preferences for thromboprophylaxis in the intensive care unit: An international survey.

Background: Venous thromboembolism (VTE) is a frequent complication in critically ill patients, who often have multiple risk factors. Pharmacological thromboprophylaxis is widely applied to lower this risk, but guidelines lack dosing recommendations.

Objective: This survey aims to assess current thromboprophylaxis preferences and willingness to participate in future randomized clinical trials (RCTs) on this topic.

Nutritional Support in the ICU.

Critical illness is a complex condition that can have a devastating impact on health and quality of life. Nutritional support is a crucial component of critical care that aims to maintain or restore nutritional status and muscle function. A one-size-fits-all approach to the components of nutritional support has not proven beneficial.

Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial.

Background: Understanding site-related factors that influence enrolment within multicenter randomized controlled trials (RCT) may help reduce trial delays and cost over-runs and prevent early trial discontinuation. In this analysis of PROSPECT (Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial), we describe patient enrolment patterns and examine factors influencing site-based monthly enrolment.

Design: Retrospective analysis of a multicenter RCT.

Characteristics and outcomes of patients with Guillain-Barré syndrome who were admitted to the intensive care unit: a retrospective observational study.

Objective: To evaluate characteristics and outcomes in critically ill patients with Guillain-Barré syndrome (GBS).

Methods: Consecutive adults with GBS who required intensive care unit (ICU) admission at a tertiary-care hospital between 1999 and 2020 were enrolled into this retrospective cohort study. Demographics, clinical data and patient outcomes were compared between patients who did or did not receive mechanical ventilation (MV).

Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method.

Purpose: To generate consensus and provide expert clinical practice statements for the management of adult sepsis in resource-limited settings.

Methods: An international multidisciplinary Steering Committee with expertise in sepsis management and including a Delphi methodologist was convened by the Asia Pacific Sepsis Alliance (APSA). The committee selected an international panel of clinicians and researchers with expertise in sepsis management.

The clinical utility of shock index in hospitalised patients requiring activation of the rapid response team.

Background: The systolic shock index (SSI) is used to direct management and predict outcomes, but its utility in patients requiring rapid response team (RRT) activation is unclear.

Objectives: We explored whether SSI can predict the outcomes of ward patients experiencing clinical deterioration and compared its performance with other parameters.

Methods: This retrospective study included adult patients in medical/surgical wards who required RRT activation.

Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial.

Importance: Sepsis screening is recommended among hospitalized patients but is supported by limited evidence of effectiveness.

Objective: To evaluate the effect of electronic sepsis screening, compared with no screening, on mortality among hospitalized ward patients.

Design, Setting, And Participants: In a stepped-wedge, cluster randomized trial at 5 hospitals in Saudi Arabia, 45 wards (clusters) were randomized into 9 sequences, 5 wards each, to have sepsis screening implemented at 2-month periods.