Near-infrared light-responsive on-demand puerarin-releasing injectable hydrogel for promoting healing of infected wounds.

Wound infection is a serious clinical challenge, often accompanied by persistent inflammatory response and the threat of increased bacterial resistance, there is an urgent requirement to develop a wound dressing with potent antimicrobial as well as immunomodulatory effects. In this study, we developed a multifunctional wound dressing to promote healing of infected wounds by doping puerarin-loaded mesoporous polydopamine nanoparticles into a carboxymethyl chitosan/sodium alginate oxide-based hydrogel. The hydrogel has good injectability, adhesion, and self-healing capabilities, and can be well matched to irregular wounds and against external injuries.

Cryogels with controllable physico-chemical properties as advanced delivery systems for biomedical applications.

Enhancing the spatiotemporal control of drug delivery holds significant potential for improving drug bioavailability, minimizing adverse reactions and toxicity, and advancing precision medicine. Traditional hydrogels have been widely recognized for their significance in substance delivery, attributed to their outstanding biocompatibility. Nevertheless, they exhibit certain limitations in the areas of controlled release and cell delivery.

A Procedural Overview of the Involvement of Small Molecules in the Nervous System in the Regulation of Bone Healing.

Clinically, a multitude of factors can contribute to the development of bone defects. In the process of bone healing, the nervous system plays a vital role in bone regeneration. Small molecules from the nervous system, such as neurotrophic factors and neuropeptides, have been found to stimulate osteoblast proliferation and differentiation by activating signaling pathways associated with bone calcification and angiogenesis.

GBR assisted Onlay bone grafting for the posterior maxillary horizontal ridge augmentation: a case report and literature review.

The posterior mandible is the primary area for occlusal function. However, long-term tooth loss in the posterior mandible often leads to rapid absorption of both buccal and lingual trabecular bone plates and subsequent atrophy of the alveolar ridge. This ultimately results in horizontal bone deficiencies that complicate achieving an optimal three-dimensional placement for dental implants.

The Application of Drugs and Nano-Therapies Targeting Immune Cells in Hypoxic Inflammation.

Immune cells are pivotal in the dynamic interplay between hypoxia and inflammation. During hypoxic conditions, HIF-1α, a crucial transcription factor, facilitates the adaptation of immune cells to the hypoxic micro-environment. This adaptation includes regulating immune cell metabolism, significantly impacting inflammation development.

Mechanically Robust and Highly Conductive Poly(ionic liquid)/Polyacrylamide Double-Network Hydrogel Electrolytes for Flexible Symmetric Supercapacitors with a Wide Operating Voltage Range.

Flexible electronic devices, such as supercapacitors (SCs), place high demands on the mechanical properties, ionic conductivity, and electrochemical stability of electrolytes. Hydrogels, which combine flexibility and the advantages of both solid and liquid electrolytes, will meet the demand. Here, we report the synthesis of novel poly(ionic liquid)/polyacrylamide double-network (DN) (PIL/PAM DN) hydrogel electrolytes containing different metal salts via a two-step γ-radiation method.

Geography-Driven Evolution of Potato Virus A Revealed by Genetic Diversity Analysis of the Complete Genome.

Potato virus A (PVA), a member of the genus , is an important potato pathogen that causes 30%-40% yield reduction to global potato production. Knowledge on the genetic structure and the evolutionary forces shaping the structure of this pathogen is limited but vital in developing effective management strategies. In this study, we investigated the population structure and molecular evolution of PVA by analyzing novel complete genomic sequences from Chinese isolates combined with available sequences from Europe, South America, Oceania, and North America.