The role of RNA binding proteins in cancer biology: A focus on FMRP.

RNA-binding proteins (RBPs) act as crucial regulators of gene expression within cells, exerting precise control over processes such as RNA splicing, transport, localization, stability, and translation through their specific binding to RNA molecules. The diversity and complexity of RBPs are particularly significant in cancer biology, as they directly impact a multitude of RNA metabolic events closely associated with tumor initiation and progression. The fragile X mental retardation protein (FMRP), as a member of the RBP family, is central to the neurodevelopmental disorder fragile X syndrome and increasingly recognized in the modulation of cancer biology through its influence on RNA metabolism.

Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.

Excessive exposure to ultraviolet (UV) radiation is a major factor in the development of skin photoaging wrinkles. While current treatments can slow the progression of photoaging, it is very difficult to achieve complete reversal. This study introduces galvanic cell microneedle (GCMN) patches with magnesium-containing bipolar electrodes.

Oncogenic HJURP enhancer promotes the aggressive behavior of triple-negative breast cancer in association with p53/E2F1/FOXM1-axis.

Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer, lacking effective targeted therapies and presenting with a poor prognosis. In this study, we utilized the epigenomic landscape, TCGA database, and clinical samples to uncover the pivotal role of HJURP in TNBC. Our investigation revealed a strong correlation between elevated HJURP expression and unfavorable prognosis, metastatic progression, and late-stage of breast cancer.

The impacts of sex and the 5xFAD model of Alzheimer's disease on the sleep and spatial learning responses to feeding time.

Introduction: The relationships between the feeding rhythm, sleep and cognition in Alzheimer's disease (AD) are incompletely understood, but meal time could provide an easy-to-implement method of curtailing disease-associated disruptions in sleep and cognition. Furthermore, known sex differences in AD incidence could relate to sex differences in circadian rhythm/sleep/cognition interactions.

Methods: The 5xFAD transgenic mouse model of AD and non-transgenic wild-type controls were studied.

Reactivating cue approached positive personality traits during sleep promotes positive self-referential processing.

People preferentially endorse positive personality traits as more self-descriptive than negative ones, a positivity self-referential bias. Here, we investigated how to enhance positive self-referential processing, integrating wakeful cue-approach training task (CAT) and sleep-based targeted memory reactivation (TMR). In the CAT, participants gave speeded motor responses to cued positive personality traits.

Observing the suppression of individual aversive memories from conscious awareness.

When reminded of an unpleasant experience, people often try to exclude the unwanted memory from awareness, a process known as retrieval suppression. Here we used multivariate decoding (MVPA) and representational similarity analyses on EEG data to track how suppression unfolds in time and to reveal its impact on item-specific cortical patterns. We presented reminders to aversive scenes and asked people to either suppress or to retrieve the scene.

Organic electrochemical transistors as on-site signal amplifiers for electrochemical aptamer-based sensing.

Electrochemical aptamer-based sensors are typically deployed as individual, passive, surface-functionalized electrodes, but they exhibit limited sensitivity especially when the area of the electrode is reduced for miniaturization purposes. We demonstrate that organic electrochemical transistors (electrolyte gated transistors with volumetric gating) can serve as on-site amplifiers to improve the sensitivity of electrochemical aptamer-based sensors. By monolithically integrating an Au working/sensing electrode, on-chip Ag/AgCl reference electrode, and Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) counter electrode - also serving as the channel of an organic electrochemical transistor- we can simultaneously perform testing of organic electrochemical transistors and traditional electroanalytical measurement on electrochemical aptamer-based sensors including cyclic voltammetry and square-wave voltammetry.

Prosocial behavior promotes positive emotion during the COVID-19 pandemic.

The COVID-19 pandemic has raised concerns about humans' physical and mental well-being. In response, there has been an urgent "call to action" for psychological interventions that enhance positive emotion and psychological resilience. Prosocial behavior has been shown to effectively promote well-being, but is this strategy effective during a pandemic when ongoing apprehension for personal safety could acutely heighten self-focused concern? In two online preregistered experiments ( = 1,623) conducted during the early stage of pandemic (April 2020), we examined this question by randomly assigning participants to engage in other- or self-beneficial action.

Neural response to rewards in youths with insomnia.

Study Objectives: Insomnia and depression are common comorbid conditions in youths. Emerging evidence suggests that disrupted reward processing may be implicated in the association between insomnia and the increased risk for depression. Reduced reward positivity (RewP) as measured by event-related potential (ERP) has been linked to depression, but has not been tested in youths with insomnia.

Sleep's short-term memory preservation and long-term affect depotentiation effect in emotional memory consolidation: behavioral and EEG evidence.

Study Objectives: Sleep plays a pivotal role in the off-line processing of emotional memory. However, much remains unknown for its immediate vs. long-term influences.

Altered brain activity related to inhibitory processing in youth with insomnia.

Insomnia has been shown to negatively affect one's cognitive functioning. While there has been some evidence suggesting sleep disruption in relation to impaired inhibitory control, a major component of executive function, little is known about the underlying neural processing in insomnia. The current study aimed to examine the differences in the behavioral responses and electroencephalography (EEG) correlates of inhibitory control between youths with insomnia and healthy sleepers.

Unit and regression tests of scientific software: A study on SWMM.

Testing helps assure software quality by executing a program and uncovering bugs. Scientific software developers often find it challenging to carry out systematic and automated testing due to reasons like inherent model uncertainties and complex floating-point computations. Extending the recent work on analyzing the unit tests written by the developers of the Storm Water Management Model (SWMM) [32], we report in this paper the investigation of both unit and regression tests of SWMM.

Scientific Software Testing Goes Serverless: Creating and Invoking Metamorphic Functions.

Our function-as-a-service (FaaS) framework transformed end users' questions into automated tests for scientific software. Our case study illustrates the FaaSification of scientific software testing and the importance of value-driven evaluations by focusing on real-world defect detection.

Optimistic amnesia: how online and offline processing shape belief updating and memory biases in immediate and long-term optimism biases.

When people are confronted with feedback that counters their prior beliefs, they preferentially rely on desirable rather than undesirable feedback in belief updating, i.e. an optimism bias.

Discovering Metamorphic Relations for Scientific Software From User Forums.

Scientific software can be used for decades and is constantly evolving. Recently, metamorphic testing, a property-based testing technique, has shown to be effective in testing scientific software, and the necessary properties are expressed as metamorphic relations. However, the development of metamorphic relations is difficult: it requires considerable practical expertise for the software tester.

Exploratory Metamorphic Testing for Scientific Software.

Scientific model developers are able to verify and validate their software via metamorphic testing, even when the expected output of a given test case is not readily available. The tenet is to check whether certain relations hold among the expected outputs of multiple related inputs. Contemporary approaches require the relations to be defined before tests.