Flexible Photovoltaic Neurostimulator for Analgesia.

Chronic neuropathic pain remains a significant clinical challenge, often requiring prolonged opioid use and exposing patients to associated complications. Current nerve electrical stimulation (ES) techniques show promise for analgesia but are constrained by their invasive nature and the potential risk of iatrogenic nerve injury. In this study, a novel approach is introduced to managing chronic pain through the development of a fully implantable, wireless, and self-adaptive photovoltaic neurostimulator (PVNS).

Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.

Excessive exposure to ultraviolet (UV) radiation is a major factor in the development of skin photoaging wrinkles. While current treatments can slow the progression of photoaging, it is very difficult to achieve complete reversal. This study introduces galvanic cell microneedle (GCMN) patches with magnesium-containing bipolar electrodes.

Using Adaptive Bandit Experiments to Increase and Investigate Engagement in Mental Health.

Digital mental health (DMH) interventions, such as text-message-based lessons and activities, offer immense potential for accessible mental health support. While these interventions can be effective, real-world experimental testing can further enhance their design and impact. Adaptive experimentation, utilizing algorithms like Thompson Sampling for (contextual) multi-armed bandit (MAB) problems, can lead to continuous improvement and personalization.