Differential gene expression and immune profiling in Parkinson's disease: unveiling potential candidate biomarkers.

Background: Parkinson's disease (PD) represents a common neurodegenerative disorder characterized by a multifaceted interaction with immune infiltration. Despite a well-defined clinical diagnosis, the misdiagnosis rate of PD remains around 20%. The aim of this study is to discover new diagnostic biomarkers for PD and investigate their pathogenesis to improve early intervention and effective management of patients with PD.

The impact of aerosol on MODIS cloud detection and property retrieval in seriously polluted East China.

Previous researches proved that aerosols have a significant influence on the Moderate Resolution Imaging Spectroradiometer (MODIS) cloud observation. In East China, this impact is much greater and special compared with other regions because of the frequent haze pollution. This study evaluated the impact of aerosols on cloud detection, cloud top height (CTH) and cloud optical thickness (COT) retrieval in East China primarily using the MODIS and Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) observation, combined with a cloud detection rectification algorithm.

The effects of initial participation motivations on learning engagement in transition training for future general practitioners in rural China: perceived deterrents as mediator.

Background: For the shortage of high-quality general practitioners (GPs) in China's rural areas, Chinese government has taken steps to encourage rural specialists to participate in transition training for future GPs. Specialists' initial participation motivations and their perceived deterrents during training may play important roles for their learning engagement in the transition training. This study aimed at revealing the relationships among the variables of initial participation motivations, perceived deterrents in training, and learning engagement.

How School Climate Influences Teachers' Emotional Exhaustion: The Mediating Role of Emotional Labor.

Currently, in China, improving the quality of teachers' emotional labor has become an urgent need for most pre-kindergarten through 12th grade (p-12) schools because the new curriculum reform highlights the role of emotion in teaching. A total of 703 primary and high school teachers in Mainland China were investigated regarding their perceptions of school climate, emotional labor strategy and emotional exhaustion via questionnaires. The findings revealed that the teachers' perceptions of the school climate negatively affected surface acting but positively affected deep acting.

Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction.

Advancing age is a major risk factor for the development of cardiovascular diseases. The aetiology of several cardiovascular disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q10 (CoQ10) acts as both an antioxidant and as an electron acceptor at the level of the mitochondria.

The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.

During aging the ability of organisms to maintain the protein homeostasis declines and damaged and misfolded proteins accumulate in cells. But whether the deterioration of protein homeostasis is the cause or consequence of aging is not clearly understood. Mitochondrial dysfunctions usually lead to increased longevity in Caenorhabditis elegans, the cause of which is believed to be the activation of protein homeostasis protective mechanisms including mitochondrial unfolded protein response (UPR(mt)) and GCN-2 kinase mediated nutrient-sensing pathway.

Molecular analysis for diagnosis of Marfan syndrome and Marfan-associated disorders.

Marfan syndrome is a systemic disorder of connective tissue, caused by mutations in the FBN1, TGFBR1 or TGFBR2 genes. This syndrome is characterized by involvement of three major systems, skeletal, ocular, and cardiovascular. The continuing improvements in molecular biology and increasing availability of molecular diagnosis in clinical practice allow recognition of Marfan syndrome in patients with incomplete phenotypes.