Development of a novel chimeric lysin to combine parental phage lysin and cefquinome for preventing sow endometritis after artificial insemination.

Sow endometritis is usually caused by multiple species of pathogenic bacteria. Numerous isolates from endometritis patients have developed antimicrobial resistance. Thus, novel antibacterial agents and strategies to combat endometritis are needed.

HBXN2020 alleviates Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation.

is a species of that has been widely investigated because of its broad-spectrum antimicrobial activity. However, most studies on have focused on the biocontrol of plant diseases, with few reports on antagonizing Typhimurium infections. In this investigation, it was discovered that HBXN2020, which was isolated from healthy black pigs, possessed strong anti-stress and broad-spectrum antibacterial activity.

Optineurin inhibits IBDV replication via interacting with VP1.

Avibirnavirus, specifically Infectious Bursal Disease Virus (IBDV), is a highly contagious pathogen that causes significant economic losses in the poultry industry. The polymerase protein VP1 of IBDV is critical to the viral life cycle, facilitating the synthesis of viral mRNA and the genome. Previous studies have suggested that various host factors influence the regulation of IBDV polymerase activity.

Chicken PRMT3 facilitates IBDV replication.

Protein arginine methyltransferases (PRMTs) in mammals play a role in various signaling pathways, such as virus infection, inflammasome responses, and cancer growth. While some PRMTs have been found to regulate interferon production in mammals, the mechanism in chickens remains to be fully understood. This study focused on investigating the function of chicken PRMTs.

Characterization and functional analysis of chicken CDK protein.

The family of cell cycle-dependent kinases (CDKs) serves as catalytic subunits within protein kinase complexes, playing a crucial role in cell cycle progression. While the function of CDK proteins in regulating mammalian innate immune responses and virus replication is well-documented, their role in chickens remains unclear. To address this, we cloned several chicken CDKs, specifically CDK6 through CDK10.

The multidrug-resistant strain: a hidden threat in boar semen preservation.

Although the bacterial composition of boar ejaculate has been extensively studied, the bacterial composition of extended boar semen is often overlooked, despite the potential risks these microorganisms may pose to the long-term preservation of extended boar semen at 15-17°C. In this study, we characterized the bacterial community composition of extended semen and discovered that spp. was the dominant flora.

Evolution of porcine reproductive and respiratory syndrome virus GP5 and GP3 genes under swIFN-β immune pressure and interferon regulatory factor-3 activation suppressed by GP5.

In this study, a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) strain, PRRSV GD07 was continuously propagated in MARC-145 cell cultures primed with swIFN-β for 50 passages to develop the PRRSV GDβfn strains. And a control strain PRRSV GDfn was passaged without swIFN-β. The sequencing analysis indicated that under swIFN-β immune pressure, molecular variation of PRRSV GP5 was accelerated in gene (NS/S>2.