Explore the Effect of Low-Intensity Focused Ultrasound on Pain Relief in Patients With Diabetic Peripheral Neuropathy: A Pilot Randomized Trial.

Objectives: To evaluate the efficacy of low-intensity focused ultrasound (LIFU) in alleviating pain in patients with painful diabetic peripheral neuropathy (PDPN).

Methods: Between November 2022 and January 2024, a total of 50 participants diagnosed with PDPN were randomly assigned to either LIFU therapy or placebo therapy. Pain levels were assessed using the numeric pain rating scale (NRS), while neuropathic symptoms and signs were evaluated using the neuropathy symptom score (NSS) and neuropathy deficit score (NDS), respectively.

Low-Intensity Pulsed Ultrasound Delays the Onset of Osteoporosis and Dyslipidemia in Mice With Premature Ovarian Insufficiency.

Objectives: The pathogenesis of premature ovarian insufficiency (POI) not only affects the ovarian structure and function but also gives rise to complications such as osteoporosis and dyslipidemia. Although low-intensity pulsed ultrasound (LIPUS) has been proven effective in treating POI, its impact on the associated complications remains unexplored. Therefore, this study aims to investigate the effects of LIPUS irradiation on osteoporosis and dyslipidemia in a mouse model of POI.